个人简介：
刘文正，博士、副教授、硕士生导师。主要从事计算生物学和合成生物学领域的研究工作。以第一作者和通讯作者在The ISME Journal、Environmental Microbiology、Food Research International、Food Microbiology等期刊发表SCI论文20余篇。主持国家自然科学基金青年基金、江苏省自然科学基金青年基金、江苏省“双创人才”双创博士项目等。课题组近年围绕“功能性益生菌筛选及其研究”等先后与江苏微康生物科技有限公司、泸州老窖股份有限公司开展横向合作，获多项发明专利。
教育背景：
2005-09至2009-06，中国海洋大学，生物科学，学士；
2009-09至2012-06，中国海洋大学，微生物学，硕士；
2013-10至2017-05，丹麦哥本哈根大学，生物学，博士
研究经历：
2017-02至2019-01，比利时列日大学，博士后;
2019-02至2019-05，南京师范大学，讲师;
2019-06至今，南京师范大学，副教授
研究方向：
1. 人工智能和计算化学辅助的小分子药物虚拟筛选、设计及优化；
2. 工程益生菌介导的肠炎靶向递送治疗研究；
3. 肠道菌群—宿主互作机制解析与疾病生物标志物挖掘（生物信息学）。
科研项目：
1. 国家自然科学基金青年基金（32202121），2023/01-2025/12，主持；
2. 江苏省自然科学基金青年基金（BK20190703），2019/07-2022/06，主持；
3. 江苏省高等学校自然科学研究面上项目（19KJB530010），2019/09-2021/08，主持；
4. 功能性益生菌筛选及其研究（横向项目），2020/09-2024/09，主持；
5. 肠道菌群对浓香型白酒中微量生物活性组分的响应性研究（横向项目），2020/06-2022/05，主持。
代表性论文（*通讯作者）：
1. Yangyang Yuan, Junke Ji, Chen Zhang, Yu Cheng, Wenzheng Liu*, Yun Jiang*. Dual-species biofilms of Escherichia coli and Pseudomonas promote temperature-dependent cross-contamination on meat surfaces[J]. Food Science and Human Wellness, 2025.
2. Yiting Lu, Yiyi Wu, Yanan Li, Weiyi Zheng*, Wenzheng Liu*. Saccharopolyspora mangrovi sp. nov., a novel mangrove soil actinomycete with distinct metabolic potential revealed by comparative genomic analysis[J]. Archives of Microbiology, 2024, 206: 342.
3. Cheng Zhen, Xinkai Chen, Xianfeng Ge, Wenzheng Liu*. Streptomonospora mangrovi sp. nov., isolated from mangrove soil showing similar metabolic capabilities, but distinct secondary metabolites profiles[J]. Archives of Microbiology, 2023, 205: 148.
4. Henriette Lyng Røder#, Wenzheng Liu#*, Søren Johannes Sørensen, Jonas Stenløkke Madsen, Mette Burmølle*. Interspecies interactions reduce selection for a biofilm optimized variant in a four-species biofilm model[J]. Environmental Microbiology Reports, 2019, 11(6): 835-839.
5. Mingzhen Liu, Miao Liu, Shenrong Yang, Caihong Shen, Xiaozhi Wang, Wenzheng Liu*, Yuxing Guo*. Fermented milk of cheese-derived Lactobacillus delbrueckii subsp. bulgaricus displays potentials in alleviating alcohol-induced hepatic injury and gut dysbiosis in mice[J]. Food Research International, 2022, 157: 111283.
6. RuiRui Huang, ShenRong Yang, Cheng Zhen, XianFeng Ge, XinKai Chen, ZhiQiang Wen, YaNan Li, Wenzheng Liu*. Genomic molecular signatures determined characterization of Mycolicibacterium gossypii sp. nov., a fast-growing mycobacterial species isolated from cotton field soil[J]. Antonie Van Leeuwenhoek, 2021a, 114(10): 1735-1744.
7. RuiRui Huang, XianFeng Ge, XinKai Chen, ShenRong Yang, Cheng Zhen, ZhiQiang Wen, YaNan Li, Wenzheng Liu*. Steroidobacter gossypii sp. nov., isolated from cotton field soil[J]. International Journal of Systematic and Evolutionary Microbiology, 2021b, 71(8).
8. Shenrong Yang, Yuanyuan Liu, Xianfeng Ge, Wenzheng Liu*. Caldimonas mangrovi sp. nov., isolated from mangrove soil[J]. Microbiology, 2023, 92: 500-507.
9. Wendong Zhang, Xiaoyu Mi, Chen Zhang, Yu Cheng, Siqi Wang, Junke Ji, Yangyang Yuan, Longfeng Wang, Wenzheng Liu*, Yun Jiang*. Meat-derived Escherichia coli and Pseudomonas fragi manage to co-exist in dual-species biofilms by adjusting gene-regulated competitive strength[J]. Food Microbiology, 2023, 109: 104122.
10. Wenzheng Liu, Henriette L. Røder, Jonas S. Madsen, Thomas Bjarnsholt, Søren J. Sørensen, Mette Burmølle. Interspecific bacterial interactions are reflected in multispecies biofilm spatial organization[J]. Frontiers in Microbiology, 2016, 7.
11. Wenzheng Liu, Jakob Russel, Henriette L. Røder, Jonas S. Madsen, Mette Burmølle, Søren J. Sørensen*. Low-abundant species facilitates specific spatial organization that promotes multispecies biofilm formation[J]. Environmental Microbiology, 2017, 19(7): 2893-2905.
12. Wenzheng Liu, Jakob Russel, Mette Burmølle, Søren J. Sørensen*, Jonas S. Madsen*. Micro-scale intermixing: a requisite for stable and synergistic co-establishment in a four-species biofilm[J]. The ISME Journal, 2018, 12: 1940-1951.
13. Wenzheng Liu#, Samuel Jacquiod#, Asker Brejnrod, Jakob Russel, Mette Burmølle, Søren J. Sørensen*. Deciphering links between bacterial interactions and spatial organization in multispecies biofilms[J]. The ISME Journal, 2019, 13: 3054-3066.
14. Xianfeng Ge, Ruirui Huang, Wenzheng Liu*. Occultella gossypii sp. nov., an alkali-resistant isolate from soil sampled in a cotton field[J]. International Journal of Systematic and Evolutionary Microbiology, 2022, 72(4).
15. Xianfeng Ge, Shenrong Yang, Cheng Zhen, Wenzheng Liu*. Actinophytocola gossypii sp. nov. and Streptomyces gossypii sp. nov., two novel actinomycetes isolated from rhizosphere soil of cotton[J]. International Journal of Systematic and Evolutionary Microbiology, 2023, 73(4).
16. Yu Cheng, Su Zhang, Chen Zhang, Xiaoyu Mi, Wendong Zhang, Longfeng Wang, Wenzheng Liu*, Yun Jiang*. Escherichia coli O157:H7 is challenged by the presence of Pseudomonas, but successfully co-existed in dual-species microbial communities[J]. Food Microbiology, 2022, 106: 104034.
17. Zhenyu Zan, Xianfeng Ge, Ruirui Huang, Wenzheng Liu*. Pseudonocardia humida sp. nov., an actinomycete isolated from mangrove soil showing distinct distribution pattern of biosynthetic gene clusters[J]. Current Microbiology, 2022, 79(3): 87.
联系方式：
Email: liu.wenzheng@njnu.edu.cn
