关淼，博士，副教授，硕士生导师
联系邮箱：08326@njnu.edu.cn
ORCID iD：https://orcid.org/0000-0002-1210-0960
ResearchGate：https://www.researchgate.net/profile/Miao-Guan-2
通信地址：南京市栖霞区文苑路1号，210023
主要研究方向：
主要从事生物信息学、生态毒理学、毒理基因组学、计算毒理学等。
教育背景与工作经历：
2018/09 - 至今， 南京师范大学，生命科学学院，讲师、副教授
2012/09 - 2018/06，南京大学，环境学院，环境生物专业，博士
2008/09 - 2012/06，南京大学，环境学院，环境生物专业，学士
课程教学：
生物信息学（本科生课程）；生物统计学（本科生课程）；环境毒理学（本科生课程）
生物信息学（研究生课程）
主持的科研项目：
1. 国家自然科学基金委员会，青年项目，基于酵母功能基因组学探究有机磷阻燃剂致毒机制及联合毒性效应，2023-2025，结题，主持；
2. 江苏省高等学校自然科学研究，面上项目，基于剂量依赖功能基因组学的有机磷阻燃剂致毒机制研究，2022-2024，结题，主持；
3. 江苏省高等学校自然科学研究，面上项目，开发基于酵母的全基因组功能缺失筛选平台，2019-2021，结题，主持；
4. 南京师范大学优秀高层次人才科研启动基金，2019-2021，结题，主持。
荣誉奖项：
2025年：
南京师范大学校级优秀本科生毕业论文（宗琳皓）全校3% 指导教师
研究生国家奖学金获得者指导教师（徐昕源）
第十届全国大学生生命科学竞赛（创新创业类）国家二等奖（宗琳皓等） 指导教师
第十届全国大学生生命科学竞赛（科学探究类）国家二等奖（倪欣等） 指导教师
第十届全国大学生生命科学竞赛（科学探究类）国家三等奖（武姿彤等） 第二指导教师
第十届全国大学生生命科学竞赛（科学探究类）国家三等奖（杨雨欣等） 协助指导
第十届全国大学生生命科学竞赛（科学探究类）国家三等奖（吴曹越等） 协助指导
第十届全国大学生生命科学竞赛（科学探究类）省级三等奖（汤紫琪等） 指导教师
大学生创新创业训练计划 省级项目（刘洋等、杨雨欣等） 指导教师
南京师范大学本科生学术论坛 优秀指导教师
第一届学术新苗培育计划本科生学术交流论坛 二等级1项/三等奖1项/优秀奖1项 指导教师
2024年：
南京师范大学“优秀教师奖”
南京师范大学2023年度“本科优秀教学奖” 一等奖
省级优秀本科生毕业论文（陈悠然）全校1% 指导教师
第九届全国大学生生命科学竞赛（创新创业类）国家一等奖（陈悠然等） 指导教师
第九届全国大学生生命科学竞赛（创新创业类）国家三等奖（操玉琪等） 指导教师
第九届全国大学生生命科学竞赛（科学探究类）国家三等奖（易芳颖等） 指导教师
第九届全国大学生生命科学竞赛（科学探究类）国家三等奖（范珂等） 第二指导教师
大学生创新创业训练计划 省级项目（范珂等） 指导教师
2023年：
南京师范大学校级优秀本科生毕业论文（许玥） 全校3% 指导教师
第八届全国大学生生命科学竞赛（科学探究类）国家三等奖（操玉琪等） 指导教师
第八届全国大学生生命科学竞赛（科学探究类）省级三等奖（陈悠然等） 第二指导教师
代表性论文（#共同一作，*通讯作者）：
生态毒理学方向：
1. Guan M, Zong L, Xu X, Zhang S, Cao D, Zhang Y, Ma F, Peng Y*, Zhang X. Unraveling Antagonistic Interactions in Complex Mixtures of Benzotriazole UV Stabilizers: A High-Throughput NAMs Approach Pinpoints Key Contributors and Underlying Pathways. Environ Sci & Technol. doi: 10.1021/acs.est.5c15702 (2026).
2. Guan M, Wang X, Xu X, Ling T, Wu J, Qian J, Ma F*, Zhang X. Bioactivity assessment of organophosphate flame retardants via a dose-dependent yeast functional genomics approach. Environ Int. 186: 108596 (2024).
3. Xu X, Zhang S, Cao D, Zong L, Chen D, Peng Y, Jin P, Ma F, Zhang X, Guan M*. Lipid Metabolism Disruption as a Conserved Early Response to Benzophenone-1: Pathway Sensitivity Profiling via Dose-Dependent Yeast Functional Genomics Platform. Environ Pollut. 389: 127439 (2026).
4. Xu X, Zong L, Zhang S, Cao D, Tang Z, Chen D, Peng Y, She L, Jin P, Zhang X, Guan M*. Deciphering early molecular responses to benzotriazole ultraviolet stabilizers-induced toxicity using a dose-dependent yeast functional genomics approach. Environ Pollut. 380:126573 (2025).
5. Guan M, Wang X, Pan Y, Xu Y, Cao Y, Yan L, Ma L*, Ma F, Zhang X. Delving into the molecular initiating event of cadmium toxification via the dose-dependent functional genomics approach in Saccharomyces cerevisiae. Environ Pollut. 323: 121287 (2023).
6. Guan M*, Yan L, Li R, Xu Y, Chen D, Li S, Ma F*, Zhang X. Integration of leave-one-out method and real-time live cell reporter array system to assess the toxicity of mixtures. Environ Res. 214: 114110 (2022).
7. Ling T, Fang Y, Zong L, Tang Z, Fan K, Chen D, Jin P*, Guan M*. A review of environmental occurrence and toxicity of benzotriazole ultraviolet stabilizers. Environ & Health. 15;3(12):1438-1455 (2025).
8. Lu X, Sun L, Chen J, Wang J, Guan M*, Xu S*. Comparative molecular insights into developmental and behavioral toxicity induced by octocrylene and ethylhexyl salicylate exposure on zebrafish. Integr Zool. Aug 21. doi: 10.1111/1749-4877.13036 (2025).
9. Pan Y, Fan K, Zong L, Luo Y, Ni X, Chen D, Qian J, Ma F, Cheng J*, Guan M*. Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster. Ecotoxicol Environ Saf. 291: 117870 (2025).
10. Zong L#, Lu X#, Yang Y, Zhao J, Tang Z, Cao D, Sun L*, Guan M*, Xu S*. Exploring potential targets and mechanisms of PCB52-induced cardiotoxicity: Integration of network toxicology and zebrafish experimental evidence. Ecotoxicol Environ Saf. 301: 118531 (2025).
11. Guan M*, Zhu Z, Jiang Y, Tian M, Yan L, Xu X, Li S, Chen D, Zhang X*. Assessment of genotoxic chemicals using chemogenomic profiling based on gene-knockout library in Saccharomyces cerevisiae. Toxicol In Vitro. 79: 105278 (2022).
12. Guan M*, Xia P, Tian M, Chen D, Zhang X*. Molecular fingerprints of conazoles via functional genomic profiling of Saccharomyces cerevisiae. Toxicol In Vitro. 69: 104998 (2020).
13. Guan M, Cao Y, Wang X, Xu X, Ning C, Qian J*, Ma F*, Zhang X. Characterizing temporal variability and repeatability of dose-dependent functional genomics approach for evaluating triclosan toxification. Sci Total Environ. 895: 165209 (2023).
14. Chen Y#, Zhao J#, Chen X, Zong L, Lu X, Pan Y, Guan M*, Zhang J*, Xu S*. Molecular insights into developmental toxicity induced by PCB77 exposure on zebrafish via integrating transcriptomics with adverse outcome pathway. Sci Total Environ. 962: 178502 (2025).
15. Zong L#, Wang X#, Huo M, Yi F, Huang S, Ling T, Fang Y, Ma F, Zhang X, Guan M*. Insights into the synergistic toxicity mechanisms caused by nano- and microplastics with triclosan using a dose-dependent functional genomics approach in Saccharomyces cerevisiae. Chemosphere. 362: 142629 (2024).
16. Guan M*, Ji W, Xu Y, Yan L, Chen D, Li S, Zhang X*. Molecular fingerprints of polar narcotic chemicals based on heterozygous essential gene knockout library in Saccharomyces cerevisiae. Chemosphere. 2022; 308: 136343 (2022).
17. Tian R#, Guan M#, Chen L, Wan Y, He L, Zhao Z, Gao T, Zong L, Chang J*, Zhang J*. Mechanism insights into the histopathological changes of polypropylene microplastics induced gut and liver in zebrafish. Ecotoxicol Environ Saf. 280: 116537 (2024).
18. Guan M, Fang W, Ullah S, Zhang X*, Saquib Q, Al-Khedhairy AA. Functional genomics assessment of narcotic and specific acting chemical pollutants using E. coli. Environ Pollut. 232: 146-153 (2018).
19. Guan M, Zhang X*. Functional genomic assessment of 2, 2-bis (bromomethyl)-1, 3-propanediol induced cytotoxicity in a single-gene knockout library of E. coli. Chemosphere. 185: 582-588 (2017).
20. Guan M, Su G, Giesy JP, Zhang X*. Classification and toxicity mechanisms of novel flame retardants (NFRs) based on whole genome expression profiling. Chemosphere. 144: 2150-2157 (2016).
生物网络与大数据分析方向：
21. Guo Y, Fan K, Tang W, Wu C, Ni X, Ling T, Zong L*, Ma F, Guan M*. Association between organophosphate flame retardant exposure and trouble sleeping: integrating epidemiological evidence with mechanistic insights. Int J Mol Sci. 27, 1934 (2026).
22. Wang L, Zong L*, Wang Y, Jiang Y, Guan M*. Prognostic role of stress granule-related gene signatures in pancreatic ductal adenocarcinoma: insights from 101-combination machine learning and single-cell sequencing. Int J Surg. doi: 10.1097/JS9.0000000000004458 (2026).
23. Wang L#, Zong L#, Cao D, Guan M*. Unraveling the molecular mechanisms of PFOA in clear cell renal cell carcinoma through network toxicology and molecular docking strategies. Int J Surg. 111: 4842-4853 (2025).
24. Qin S#, Yao X#, Li W#, Wang C#, Xu W, Gan Z, Yang Y, Zhong A, Wang B, He Z, Wu J, Wu Q, Jiang W, Han Y, Wang F, Wang Z, Ke Y, Zhao J, Gao J, Qu L, Jin P, Guan M*, Xia X*, Bian X*. Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients. Cell Death Dis. 14(4): 286 (2023).
25. Chen Y#, Pan Y#, Gao H, Yi Y, Qin S, Ma F, Zhou X*, Guan M*. Mechanistic insights into super-enhancer-driven genes as prognostic signatures in patients with glioblastoma. J Cancer Res Clin Oncol. 149(13): 12315-12332 (2023).
26. Yi Y, Liu X, Gao H, Qin S, Xu J, Ma F, Guan M*. The Tumor Stemness Indice mRNAsi can Act as Molecular Typing Tool for Lung Adenocarcinoma. Biochem Genet. 61(6): 2401-2424 (2023).
27. Xu J, Qin S, Yi Y, Gao H, Liu X, Ma F, Guan M*. Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-Seq. Int J Mol Sci. 23(17): 9936 (2022).
28. Chen H#, Xue J#, Zhang Z#, Zhang G#, Xu X, Li H, Zhang R, Ullah N, Chen L, Amanullah, Zang Z, Lai S, He X, Li W, Guan M*, Li J*, Chen L*, Deng C*. High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote. Sci Rep. 12(1): 2289 (2022).
29. Chen D*, Zhao Q, Xia S, Li L, Guan M*, Size distribution of light absorption of carbonaceous aerosols over rural, urban and industrial sites in a typical polluted city in Yangtze River Delta, China. Air Qual Atmospher Health. 15, 1953 - 1961 (2022).
30. Chen D, An Z, Zhao Q, Xia S, Li L, Guan M*, Study of Variations in Mass Absorption Efficiency of Elemental Carbon Influenced by Different Measurement Techniques and Vehicle Emission. Front Environ Sci. 9, 812039 (2021).
合作论文
31. He X, Xu J, Zhang S, Hu M, Wang C, Guan M, Li P, Chen L, Lin L, Ward-Fear G, Li H*. Embryonic exposure to nanoplastics affects the metabolism and locomotor performance of a soil-dwelling, oviparous skink. Environ Pollut. 384: 126986 (2025).
32. Chen D*, Zhao Z, Liu Y, Ye Z, Guan M. Characterization and source apportionment of brown carbon via online measurements in a typical industrial-polluted city in eastern China. Environ Res. 278:121731 (2025).
33. Chen D, Zhao W, Zhang L*, Zhao Q*, Zhang J, Chen F, Li H, Guan M, Zhao Y. Characterization and source apportionment for light absorption amplification of black carbon at an urban site in eastern China. Sci Total Environ. 865: 161180 (2023).
34. Liu J#, Shu M#, Liu S, Xue J, Chen H, Li W, Zhou J, Amanullah A, Guan M, Bao J*, Pu D*, Deng C*. Differential MC5R loss in whales and manatees reveals convergent evolution to the marine environment. Dev Genes Evol. 232(2-4): 81-87 (2022).
35. Morandi GD, Wiseman SB, Guan M, Zhang XW*, Martin JW, Giesy JP*. Elucidating mechanisms of toxic action of dissolved organic chemicals in oil sands process-affected water (OSPW). Chemosphere. 186: 893-900 (2017).
36. Jung D, Guan M, Lee S, Kim C, Shin H, Hong S, Yim UH, Shim WJ, Giesy JP, Khim JS, Zhang X*, Choi K*. Searching for novel modes of toxic actions of oil spill using E. coli live cell array reporter system - A Hebei Spirit oil spill study. Chemosphere. 169: 669-677 (2017).
37. Xia P, Zhang X*, Xie Y, Guan M, Villeneuve DL, Yu H. Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening. Environ Sci Technol. 50(19): 10682-10692 (2016).
38. Hug C*, Zhang X, Guan M, Krauss M, Bloch R, Schulze T, Reinecke T, Hollert H, Brack W. Microbial reporter gene assay as a diagnostic and early warning tool for the detection and characterization of toxic pollution in surface waters. Environ Toxicol Chem. Nov; 34(11): 2523-32 (2015).
学术兼职信息：
担任Nature Communications、Environmental Science and Technology、Environmental Chemistry and Ecotoxicology、Environmental Research、Aquatic toxicology、Ecotoxicology and environmental safety、Pesticide biochemistry and physiology等国际学术期刊的审稿人。
招生情况：
热忱欢迎对生物信息学、生态毒理学感兴趣的有志青年报考硕士研究生；也欢迎想进入实验室学习做竞赛、大创、毕设的本科生进入我们团队！
