李健 理学博士，副教授，硕士生导师

邮箱：jian@njnu.edu.cn  

教育背景：

(1) 2012.09-2015.06，湖南师范大学, 生态学, 理学博士

(2) 2009.09-2012.06，湖南师范大学, 植物学, 理学硕士

(3) 2005.09-2009.06，湖南师范大学, 生物科学, 理学学士

工作经历：

(1) 2024.07至今，   南京师范大学，生命科学学院，副教授

(2) 2024.01至今，   南京师范大学，生命科学学院，特岗研究员

(3) 2019.02-2024.01，南方科技大学，生命科学学院，研究助理教授

(4) 2015.07-2018.12，北京大学，生命科学学院/现代农学院，博士后

主要科研领域与方向：

本课题组主要从事植物光信号转导机制研究。“万物生长靠太阳”，光既是能量还是信号，在拟南芥幼苗阶段，光控形态建成对多个特色鲜明的生物学事件的正常进行至关重要，包括幼苗的出土存活、光合作用开启以及营养方式转变等。大量的研究揭示了基因转录的重编程以及泛素-蛋白酶体系统控制的蛋白降解在光控形态建成中的核心作用。课题组则拟利用分子遗传学及生物化学手段来进一步解析（1）光控蛋白翻译在光形态建成中的作用及机制；（2）非蛋白降解型泛素化在光形态建成中的作用及机制。期望为理解植物环境适应性的分子机理、为促进植物性蛋白质资源的生产与利用提供一定的理论基础。

代表项目（主持）：

1. 南京师范大学优秀高层次人才科研启动经费，2024.01-2027.01

2. 国家自然科学青年科学基金项目“COP1介导BIN2非降解型泛素化调控拟南芥光形态建成的分子机理”，32200198，2023.01-2025.12，30万

3. 北大-清华生命科学联合中心（CLS）杰出博士后基金，2017.04-2018.12

一作/通讯作者论文：

(7) Liu Yongting, Xie Yinpeng, Xu Dongqing, Deng Xing Wang^*, Li Jian^*. Inactivation of GH3.5 by COP1-mediated K63-linked ubiquitination promotes seedling hypocotyl elongation. Nature Communications, 2025. 16(1): 3541. (^*共同通讯)

(6) Cai Yupeng^#, Liu Yongting^#, Fan Yangyang, Li Xitao, Yang Maosheng, Xu Dongqing, Wang Haiyang, Deng Xing Wang^*, Li Jian^*, MYB112 connects light and circadian clock signals to promote hypocotyl elongation in Arabidopsis. The Plant Cell, 2023. 35(9): 3485-3503. (^*共同通讯)

(5) Lan Hongxia ^#, Heng Yueqin ^#, Li Jian ^#, Zhang Mengdi, Bian Yeting, Chu Li, Jiang Yan, Wang Xuncheng, Xu Dongqing^*, Deng Xing Wang^*, COP1 SUPPRESSOR 6 represses the PIF4 and PIF5 action to promote light-inhibited hypocotyl growth. Journal of Integrative Plant Biology, 2022. 64(11): 2097-2110. (^#共同一作)

(4) Yan Tingting, Heng Yueqin, Wang Wenwei, Li Jian^*, and Deng Xing Wang^*, SWELLMAP 2, a phyB-interacting splicing factor, negatively regulates seedling photomorphogenesis in Arabidopsis. Frontiers in Plant Science, 2022. 13. (^*共同通讯)

(3) Li Jian, Terzaghi William, Gong Yanyan, Li Congran, Ling Jun-Jie, Fan Yangyang, Qin Nanxun, Gong Xinqi^*, Zhu Danmeng^*, Deng Xing Wang^*, Modulation of BIN2 kinase activity by HY5 controls hypocotyl elongation in the light, Nature Communications, 2020. 11(1). H1 Connect (原F1000)推荐

(2) Ling Jun-Jie^#, Li Jian^#, Zhu Danmeng^*, Deng Xing Wang^*, Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness, Proceedings of the National Academy of Sciences of the United States of America, 2017. 114(13): 3539-3544. (^#共同一作)

(1) Li Jian, Huang Yuan, Tan Hong, Yang Xiao, Tian Lianfu, Luan Sheng, Chen Liangbi^*, Li Dongping^*, An endoplasmic reticulum magnesium transporter is essential for pollen development in Arabidopsis, Plant Science, 2015. 231: 212-220.

参与论文：

(6) Zhou Hua, Zeng Haiyue, Yan Tingting, Chen Sunlu, Fu Ying, Qin Guochen, Zhao Xianhai, Heng Yueqin, Li Jian, Lin Fang, Xu Dongqing, Wei Ning, Deng Xing Wang. Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis. Nature Communications, 2024. 15(1): 5130.

(5) Wang Yidong^#, Wang Lixia^#, Guan Zeyuan ^#, Chang Hongfei, Ma Ling, Shen Cuicui, Qiu Liang, Yan Junjie, Zhang Delin, Li Jian, Deng Xing Wang^*, Yin Ping^*, Structural insight into UV-B-activated UVR8 bound to COP1. Science Advances, 2022. 8(16): eabn3337.

(4) Zhou Hua^#, Zhu Wei^#, Wang Xuncheng^#, Bian Yeting, Jiang Yan, Li Jian, Wang Lixia, Yin Ping, Deng Xing Wang^*, and Xu Dongqing^*, A missense mutation in WRKY32 converts its function from a positive regulator to a repressor of photomorphogenesis. New Phytologist, 2022. 235(1): 111-125.

(3) Lin Fang, Jiang Yan, Li Jian, Yan Tingting, Fan Liuming, Liang Jiansheng, Chen Z. Jeffrey, Xu Dongqing^*, Deng Xing Wang^*, B-BOX DOMAIN PROTEIN28 negatively regulates photomorphogenesis by repressing the activity of transcription factor HY5 and undergoes COP1-mediated degradation. The Plant Cell, 2018. 30 (9): 2006-2019.

(2) Wang Yuqiu, Li Jian, Deng Xing Wang, Zhu Danmeng, Arabidopsis noncoding RNA modulates seedling greening during deetiolation. Science China Life Sciences, 2018. 61(2): 199-203.

(1) Zhao Xianhai, Jiang Yan, Li Jian, Huq Enamul, Chen Z. Jeffrey, Xu Dongqing^*, Deng Xing Wang^*, COP1 SUPPRESSOR 4 promotes seedling photomorphogenesis by repressing CCA1 and PIF4 expression in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 2018. 115 (45): 11631-11636.