潘飞燕

学习和工作经历：

副教授，博士，硕士研究生导师，1996-2000年南京师范大学就读本科；2000年7月至今，留校工作；2002-2005年在职攻读硕士学位；2007-2010年在职攻读博士学位。2009年6月台湾国立卫生研究院访问学习；2014-2015年到美国俄克拉荷马大学访问学者；2016年7月芬兰赫尔辛基大学访问学者。目前是中国细胞生物学学会会员, 江苏省生化学会会员，江苏省发育生物学会会员。

研究方向：

1. 碱基切除修复对肿瘤发生发展的作用机制研究；

2. 肿瘤基因治疗与细胞治疗的分子基础研究；

3. 肿瘤细胞抗药性的分子机理研究。

主持项目：

1. GAPDH调节RAD51蛋白稳定性参与DNA双链断裂修复的机制研究（23KJA180002），江苏省高等学校自然科学重大项目，在研，主持；

2. GAPDH 在肿瘤细胞抗药性中的作用机制研究（18KJA180006），江苏省高等学校自然科学重大项目，结题，主持；

3. Egr-1通过调控PRL-3转录与翻译后修饰促进肝癌细胞离散（30800574），国家自然科学基金青年基金项目，结题，主持；

4. HGF/Egr-1/PRL-3/Ezrin/E-cadherin 信号通路影响HepG2细胞离散（BK2008432），江苏省自然科学基金，结题，主持；

5. 活体、动态观察小分子化合物对信号通路转导作用的细胞模型的建立（07KJD180103），江苏省高校自然科学基金，结题，主持。

近五年发表论文（*通讯作者）：

1. Xu L, Pan F*, Guo Z*. TIPE2: A Candidate for Targeting Antitumor lmmunotherapy. J Immunol, 2024, 212 (5): 755-763.

2. Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Wang S, Yang Y, Guo Z*, Pan F*. GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner. EMBO Reports, 2023, 24 (8) :e56437.

3. Zhao X, Ma Y, Shi M, Huang M, Xin J, Ci S, Chen M, Jiang T, Hu Z, He L, Pan F*, Guo Z*. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1. Cell Mol Life Sci, 2023, 80:159.

4. Shi M, Hou J, Shao S, Liang W, Wang S, Yang Y, Guo Z, Pan F*. Short-Term Starvation Weakens the Efficacy of Cell Cycle Specific Chemotherapy Drugs through G1 Arrest. Int J Mol Sci, 2023, 24:2498.

5. Ma Y, Yang Y, Xin J, He L, Hu Z, Gao T, Pan F*, Guo Z*. RNA G-Quadruplex within the 5′-UTR of FEN1 Regulates mRNA Stability under Oxidative Stress. Antioxidants, 2023, 12:276.

6. Gu L^#, Sun Y^#, Wu T^#, Chen G, Tang X, Zhao L, He L, Hu Z, Sun L, Pan F^*, Yin Z^*, Guo Z^*. A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency. Cell Death Dis, 2022, 13:583.

7. Huang M^#, Wu T^#, Liu R, Wang M, Shi M, Xin J, Shao S, Zhao X, Ma Y, Gu L,  Guo Z, Pan F^*. Polb modulates the expression of type I interferon via STING pathway. Biochem Bioph Res Co, 2022, 621:137-143.

8. Wang W^#, Ma Y^#, Huang M, Liang W, Zhao X, Li Q, Wang S, Hu Z, He L, Gao T, Chen J, Pan F^*, Guo Z^*. Asymmetrical arginine dimethylation of histone H4 by 8-oxoG/OGG1/PRMT1 is essential for oxidative stress induced transcription activation. Free Radical Bio Med, 2021, 164:175-186.

9. Wu T^#, Zhu H^#, Zhang M, Sun Y, Yang Y, Gu L, Zhang J, Mu D, Wu C, Hu Z, Jiang L, Jia S, Zhang Y, He L^*, Pan F^*, Guo Z^*. FEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway. Gene Therapy, 2021.

10. Ma Z^#, Wang W^#, Wang S, Zhao X, Ma Y, Wu C, Hu Z, He L, Pan F^*, Guo Z^*. Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress. Redox Biol, 2020, 37:101653.

11. He L^#, Hu Z^#, Sun Y^#, Zhang M, Zhu H, Jiang L, Zhang Q, Mu D, Zhang J, Gu L, Yang Y, Pan F^*, Jia S^*, Guo Z^*. PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells. DNA Repair, 2020, 95:102953.

12. Ci S^#, Xia W^#, Liang W, Qin L, Zhang Y, Dianov GL, Wang M, Zhao X, Wu C, Alagamuthu KK, Hu Z, He L, Pan F^*, Guo Z^*. Src-mediated phosphorylation of GAPDH regulates its nuclear localization and cellular response to DNA damage. FASEB J, 2020, 34:10443-10461.

13. Wang M, Long K, Li E, Li L, Li B, Ci S, He L, Pan F, Hu Z^*, Guo Z^*. DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation. Oncogene, 2020, 39(33):5507-5519.

14. Xia W#, Ci S#, Li M, Wang M, Dianov GL, Ma Z, Li L, Hua K, Alagamuthu KK, Qing L, Luo L, Edick AM, Liu L, Hu Z, He L, Pan F*, Guo Z*: Two-way crosstalk between BER and c-NHEJ repair pathway is mediated by Pol b and Ku70. FASEB J, 2019, 33(11).

Email：panfeiyan@njnu.edu.cn