何凌峰，副教授，硕士生导师
电子邮件：lfhe22@139.com
研究方向：
DNA损伤修复和肿瘤生物学
靶向DNA修复途径的小分子抑制剂
噬菌体展示与单克隆抗体药物研发
免疫细胞治疗研究
何凌峰博士2009年毕业于中科院上海生化细胞所，获中国科学院生化与分子生物学专业博士学位。毕业后赴美国哈佛医学院做博士后研究，2013年回国任职于南京师范大学生命科学学院，副教授，硕士生导师。回国后先后主持了江苏省自然科学基金、教育部留学回国人员科研启动基金、南师大高层次人才科研启动项目、企业横向合作抗体研发等科研项目。回国至今发表多篇科研论文出版在Oncogene, EBioMedicine,Molecular Oncology,Experimental & Molecular Medicine,DNA Repair, Molecular Cancer Therapeutics, Gene Therapy,Immunology等国际知名学术期刊。
近年发表的学术论文：
Yin X, He L, Guo Z.T-cell exhaustion in CAR-T-cell therapy and strategies to overcome it.Immunology.2023 Mar 20. doi: 10.1111/imm.13642.Online ahead of print.PMID: 36942414. Review.
Ting Wu,Hongqiao Zhu,Miaomiao Zhang,Yuling Sun,Yongjing Yang,Lili Gu,Jing Zhang,Dan Mu,Congye Wu,Zhigang Hu,Longwei Jiang,Shaochang Jia,Ying Zhang,Lingfeng He,Fei-Yan Pan,Zhigang Guo.FEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway.Gene Therapy. 2022 Aug;29(7-8):407-417.
Gu L, Sun Y, Wu T, Chen G, Tang X, Zhao L, He L, Hu Z, Sun L, Pan F, Yin Z, Guo Z.A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency.Cell Death Dis. 2022 Jul 6;13(7):583.
Li E, Xia M, Du Y, Long K, Ji F, Pan F, He L, Hu Z, Guo Z.METTL3 promotes homologous recombination repair and METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis.Elife. 2022 May 3;11:e75231. doi: 10.7554/eLife.75231.
Kaili Long,Lili Gu,Lulu Li,Ziyu Zhang,Enjie Li,Yilan Zhang,Lingfeng He,Feiyan Pan,Zhigang Guo,Zhigang Hu.Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.Cell Death Dis. 2021 May 18;12(6):503. DOI:10.1038/s41419-021-03804-7
Lihong Qin,Mao Huiwen,Jianguo Wang,Yuanyaun Wang,Salman A Khan,Ying Zhang,Hong Qiu,Longwei Jiang,Lingfeng He,Yan Zhang,Shaochang Jia.A novel polymerase β inhibitor from phage displayed peptide library augments the anti-tumour effects of temozolomide on colorectal cancer.J Chemother. 2021 Dec 6;1-10.
Lingfeng He#,Zhigang Hu#,Yuling Sun*,Miaomiao Zhang,Hongqiao Zhu,Longwei Jiang,Qi Zhang,Dan Mu,Jing Zhang,Lili Gu,Yang Yang,Fei-Yan Pan*,Shaochang Jia*,Zhigang Guo*.PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.DNA Repair (Amst) 2020 Nov;95:102953. DOI: 10.1016/j.dnarep.2020.102953.
Ci S, Xia W, Liang W, Qin L, Zhang Y, Dianov GL, Wang M, Zhao X, Wu C, Alagamuthu KK, Hu Z,He L, Pan F, Guo Z.Src-mediated phosphorylation of GAPDH regulates its nuclear localization and cellular response to DNA damage.FASEB J. 2020 Jun 15. doi: 10.1096/fj.201902904RR. Online ahead of print. PMID: 32539222.
Zhuang Ma,Wentao Wang,Shiwei Wang,Xingqi Zhao,Ying Ma,Congye Wu,Zhigang Hu,Lingfeng He,Feiyan Pan,Zhigang Guo.Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress.Redox Biol 2020 Oct;37:101653.
Zhu H, Wu C, Wu T, Xia W, Ci S, He W, Zhang Y, Li L, Zhou S, Zhang J, Edick AM, Zhang A, Pan FY, Hu Z,He L*, Guo Z*.Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1.Mol Cancer Ther. 2019 Aug 29.
Lu X, Liu R, Wang M, Kumar AK, Pan F,He L, Hu Z, Guo Z.MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer.Oncogene. 2020 Jan;39 (1):234-247. doi: 10.1038/s41388-019-0986-0. Epub 2019 Aug 30. PMID:31471584.
Xia W, Ci S, Li M, Wang M, Dianov GL, Ma Z, Li L, Hua K, Alagamuthu KK, Qing L, Luo L, Edick AM, Liu L, Hu Z,He L, Pan F, Guo Z.Two-way crosstalk between BER and c-NHEJ repair pathway is mediated by Pol-β and Ku70.FASEB J. 2019 Nov;33(11):11668-11681.
Lingfeng He#,Hong Zhu#, Shiying Zhou#, Ting Wu#, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan and Zhigang Guo.Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells.Experimental & Molecular Medicine.2018 Aug 14;50(8):101.
Lingfeng He#,Huan Yang#, Shiying Zhou#, Hong Zhu, Huiwen Mao, Zhuang Ma, Ting Wu,Alagamuthu Karthick Kumar, Chandrasekhar Kathera, Avilala Janardhan, Feiyan Pan, Zhigang Hu, Yanhua Yang, Libo Luo, Zhigang Guo.Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells.DNA Repair.2018 Mar; 63:1-9. doi: 10.1016/j.dnarep.2018.01.003.
He L#, Luo L#, Zhu H, Yang H, Zhang Y, Wu H, Sun H, Jiang F, Kathera CS, Liu L, Zhuang Z, Chen H, Pan F, Hu Z, Zhang J, Guo Z.FEN1 Promotes Tumor Progress and Confers Cisplatin Resistance in Non-Small Cell Lung Cancer. Molecular Oncology. 2017 Jun;11(6):640-654. doi: 10.1002/1878-0261.12058. Epub 2017 May 12.
Hongfang Sun#,Lingfeng He#, Huan Wu#, Feiyan Pan, Xuping Wu, Jing Zhao, ZhigangHu,Chandra Sandra, Binghui Shen, Zhigang Guo.The FEN1 L209P mutation interferes with long patch base excision repair and induces cellular transformation. Oncogene 2017 Jan 12;36(2):194-207.
Lingfeng He#, Yilan Zhang#, Hongfang Sun#, Feng Jiang, Huan Yang, Huan Wu, Ting Zhou, Sencai Hu, Chandra Sekhar Kathera, Xiaojun Wang, Haoyan Chen, Hongzhi Li, Binghui Shen, Yongqiang Zhu, Zhigang Guo.Targeting DNA Flap Endonuclease 1 to impede breast cancer progression.EBioMedicine.2016 Dec;14:32-43. doi: 10.1016/j.ebiom.2016.11.012. Epub 2016 Nov 10.
