卢山 博士
细胞与发育生物学教授、硕导
Email：lu_shan@hotmail.com
联系地址：南京市栖霞区文澜路北南师大老北区
南京师范大学生命科学学院163信箱
邮编：210023
2004年获日本国立Tottori University博士学位后，即工作于美国公立University of Cincinnati College of Medicine，2009年回国至今工作于南京师范大学生命科学学院分子细胞生物研究所。多年来一直从事前列腺癌发生发展机理及调控相关研究，主要在分子、细胞、小动物水平上探究影响前列腺肿瘤生长和转移等细胞信号转导的分子机制等，为开发前列腺癌治疗方法提供新的药物靶点和思路。
目前研究方向主要集中于前列腺肿瘤进展过程中发挥重要作用的EMT和PD-L1信号通路相关分子调控机理方面的研究。
代表性论文
1）Yu Zhang; Yong Wei; Shun Jiang; Yanmei Dang; Yu Yang; Wenren Zuo; Qingyi Zhu; Ping Liu; Yanhong Gao; Shan Lu. Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling, Phytomedicine. 2022, 99: 153939.
2）Tonghui Li, Fangfang Wang, Yanmei Dang, Jiajie Dong, Yu Zhang, Chi Zhang, Ping Liu, Yanhong Gao, Xiaojun Wang, Sijun Yang, Shan Lu. P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice. Int J Biol Sci. 2019, 15(10):2198-2210.
3）Xiaowei Diao, Xiubin Chen, Yurui Pi, Yu Zhang, Fangfang Wang, Ping Liu, Yanhong Gao, Xiaojun Wang, Sijun Yang, Shan Lu. Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1. Oncol Rep. 2018, 40(2):1174-1184.
4）Shan Lu; Qingyi Zhu; Yi Zhang; Wei Song; MJ Wilson; Ping Liu. Dual-Functions of miR-373 and miR-520c by Differently Regulating the Activities of MMP2 and MMP9, J Cell Physiol. 2015, 230(8): 1862-1870.
5）Shan Lu; Zongqin Tan; Matt Wortman; Zhongyun Dong; Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells, Int J Oncol. 2010, 36(2): 459-467.
6）Shan Lu; Zongqin Tan; Matthew Wortman; Shan Lu; Zhongyun Dong; Preferential Induction of G1 Arrest in Androgen Responsive Human Prostate Cancer Cells by Androgen Receptor Signaling Antagonists DL3 and antiandrogen bicalutamide, Cancer Lett. 2010, 298(2): 250-257.
7）Shan Lu; Amy Wang; Shan Lu; Zhongyun Dong; A novel synthetic compound that interrupts androgen receptor signaling in prostate cancer cells, Mol Cancer Ther. 2007, 6(7): 2057-2064.
8）Shan Lu; Zhongyun Dong; Characterization of TGF-b-Regulated Interleukin-8 Expressionin Human Prostate Cancer Cells, Prostate. 2006, (66): 996-1004.
9）Shan Lu; Kohji Nishimura; Mohammad A. Hossain; Mitsuo Jisaka; Tsutomu Nagaya; Kazushige Yokota; Regulation and role of arachidonate cascade during changes in life cycle of adipocytes, Appl Biochem Biotechnol. 2004, 118(1-3): 133-153.
10）Shan Lu, Ma Ohya, Kohji Nishimura, Mitsuo Jisaka, Tsutomu Nagaya, Kazushige Yokota. Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes, Adv Exp Med Biol. 2003, (525): 153-156.
