个人简介
博士，教授、博士生导师。获江苏省特聘教授、江苏省杰出青年基金、江苏省六大人才高峰高层次人才项目、南京师范大学中青年领军人才项目资助。分子细胞生物学研究所所长。以通讯或第一作者在PNAS、Developmental Cell、Journal of Biological Chemistry、Cell Reports、JACS、Nucleic Acids Research等杂志上发表论文40多篇。主要研究兴趣为膜运输及相关疾病的分子机理。
教育和工作经历
2017年12月至今，南京师范大学生命科学学院分子细胞生物学研究所，教授；
2009年10月-2017年8月，美国科罗拉多大学博尔德分校分子细胞发育生物系，博士后研究助理；
2003年9月-2009月1月，中国科学院长春应用化学研究所化学生物学实验室，获博士学位；
1999年9月-2003年6月，东北师范大学，获学士学位。
研究领域
糖稳态维持的调控机制；
神经递质分泌和神经退行性疾病的分子机理；
细胞内膜接触位点和细胞间通讯的功能研究。
承担的科研项目
先后主持国家自然科学基金青年基金、面上项目、重大研究计划培育项目，NIH R03项目，江苏省特聘教授项目，江苏省杰出青年基金和省六大人才高峰高层次人才项目。
代表性论文
1. He R., Liu F., Wang H., Huang S., Xu K., Zhang C., Liu Y.*, Yu H.*, ORP9 and ORP10 form a heterocomplex to transfer phosphatidylinositol 4-phosphate at ER-TGN contact sites. Cell. Mol. Life Sci., 2023, 80, 77.
2. Liu F., He R., Zhu M., Zhou L., Liu Y.*, Yu H.*, Assembly-promoting protein Munc18c stimulates SNARE-dependent membrane fusion through its SNARE-like peptide, J. Biol. Chem., 2022, 298, 102470.
3. Qian T.#, Li C.#, Liu F.#, Xu K., Wan C., Liu Y.*, Yu H.*, Arabidopsis synaptotagmin 1 mediates lipid transport in a lipid composition-dependent manner, Traffic, 2022, 23, 346-356.
4. Xu B., Huang S., Liu Y.*, Wan C., Gu Y., Wang D.*, Yu H.*, Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition, J. Biol. Chem., 2022, 298, 101469.
5. Qian T., Li C., He R., Wan C., Liu Y.*, Yu H.*, Calcium-dependent and -independent lipid transfer mediated by tricalbins in yeast, J. Biol. Chem., 2021, 296, 100729.
6. Li C., Qian T., He R., Wan C., Liu Y.*, Yu H.*, Endoplasmic Reticulum-Plasma Membrane Contact Sites: Regulators, Mechanisms, and Physiological Functions, Front. Cell Dev. Biol., 2021, 9, 627700.
7. Liu Y.#, Wan C.#, Rathore S.S., Stowell M.H.B., Yu H.*, Shen J.*, SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting, Cell Rep., 2021, 34, 108611.
8. Wang S., Liu Y., Crisman L., Wan C., Miller J., Yu H.*, Shen J.*, Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis, Traffic, 2020, 21, 636-646.
9. Rathore S.S.#, Liu Y.#, Yu H.*, Wan C., Lee M., Yin Q., Stowell M.H.B., Shen J.*, Intracellular vesicle fusion requires a membrane-destabilizing peptide located at the juxtamembrane region of the v-SNARE, Cell Rep., 2019, 29, 4583-4592.
10. Gulbranson D.R., Crisman L., Lee M., Ouyang Y., Menasche B.L., Demmitt B.A., Wan C., Nomura T., Ye Y., Yu H.*, Shen J.*, AAGAB controls AP2 adaptor assembly in clathrin-mediated endocytosis, Dev. Cell, 2019, 50, 436-446.
11. Yu H., Shen C., Liu Y., Menasche B.L., Ouyang Y., Stowell M.H.B., Shen J.*，SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins，Proc. Natl. Acad. Sci. U S A, 2018, 115, E8421-8429.
12. ##*Gulbranson D.R., Kogut I., Bilousova G., Zhang C., Stowell M.H.B., Shen J.*, The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis, J. Biol. Chem., 2018, 293, 18309-18317.
13. Gulbranson D.R., Davis E.M., Demmitt B.A., Ouyang Y., Ye Y., Yu H.*, Shen J.* RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc. Natl. Acad. Sci. U S A, 2017, 114, E8224-E8233.
14. Yu H., Liu Y., Gulbranson D.R., Paine A., Rathore S.S., Shen J.*，Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites，Proc. Natl. Acad. Sci. U S A, 2016, 113, 4362-4367.
15. #Rathore S.S.#, Shen C., Liu Y., Ouyang Y., Michael H. Stowell, Shen J.*, Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding, J. Am. Chem. Soc., 2015, 137, 12873-12883.
16. Shen C.#, Rathore S.S.#, Yu H.#, Gulbranson D.R., Hua R., Zhang C., Schoppa N.E., Shen J.*，The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis, Nat. Commun., 2015, 6, 8852.
Rathore S.S., Gulbranson D.R., Shen J.*, The N- and C-terminal domains of tomosyn play distinct roles in SNARE binding and fusion regulation, J. Biol. Chem., 2014, 289, 25571-25580.
18. Rathore S.S., Lopez J.A., Davis E.M., James D.E., Martin J.L., Shen J.*, Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins, Proc. Natl. Acad. Sci. U S A, 2013, 110, E3271-3280.
19. , , , , , , , *, Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide, Chem. Sci., 2012, 3, 3145-3153.
20. Yu H., Wang X., Fu M., Ren J., Qu X.*, Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res., 2008, 36, 5695-5703.
联系方式
邮件：yuhaijia@njnu.edu.cn
通讯地址：江苏省南京市文苑路1号，南京师范大学生命科学学院，邮编：210023
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