个人简介
张石柱，博士、教授、博士生导师。主要以人类致病真菌烟曲霉为材料，研究真菌致病因子和耐药相关的分子机制以及抗真菌药物的开发。研究成果发表在 mBio, NPJ Biofilms Microbiomes, Molecular Microbiology, Cellular Microbiology, Virulence, Applied Environmental Microbiology等国际权威杂志。
教育和工作经历
2011-至今：南京师范大学，副教授、教授
2016-2017：加拿大麦吉尔大学，访问学者
2008-2010：美国佛罗里达大学，联合培养博士
2004-2010：重庆大学，硕士、博士
2000-2004：鲁东大学，学士
研究方向
烟曲霉是一种重要的致病真菌，在免疫缺陷病人或者肺部有损伤的病人中可以引发死亡率很高的侵袭性曲霉病，对人类公共健康安全构成了威胁。我们实验室主要以烟曲霉为材料，利用遗传学、生物化学和分子生物学等技术手段，研究真菌致病因子和耐药相关的调控机制，为抗真菌药物的开发提供支持。
具体研究方向
（1）真菌生物被膜形成和耐药机制
（2）环境因素对真菌耐药性的影响
主持项目
（1）国家自然科学基金面上项目（2025-2028）
（1）国家自然科学基金面上项目（2022-2025）
（2）国家自然科学基金面上项目（2015-2018）
（3）国家自然科学基金青年项目（2013-2015）
（4）教育部博士点基金新教师类（2013-2015)
（5）江苏省自然科学基金青年项目（2013-2015）
发表论文
1. Liu S, Lu XY, Dai MY, Zhang SZ. 2023. Transcription factor CreA is involved in the inverse regulation of biofilm formation and asexual development through distinct pathways in. Molecular Microbiology 120:830-844.
2. Dai MY, Du WL, Lu L, Zhang SZ. 2023. Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions. Applied and Environmental Microbiology 89.
3. Dai MY, Liu XT, Goldman GH, Lu L, Zhang SZ. 2024. The EH domain-containing protein, EdeA, is involved in endocytosis, cell wall integrity, and pathogenicity in Aspergillus fumigatus. Msphere 9.
4. Chen Y, Stewart JIP, Liu S, Sheppard DC, Lu L, Zhang S. 2022. Spt20, a Structural Subunit of the SAGA Complex, Regulates Aspergillus fumigatus Biofilm Formation, Asexual Development, and Virulence. Appl Environ Microbiol 88:e0153521.
5. Liu S, Le Mauff F, Sheppard DC, Zhang S. 2022. Filamentous fungal biofilms: Conserved and unique aspects of extracellular matrix composition, mechanisms of drug resistance and regulatory networks in Aspergillus fumigatus. NPJ Biofilms Microbiomes 8:83.
6. Chen Y, Stewart JIP, Liu S, Sheppard DC, Lu L, Zhang S. 2021. Spt20, a structural subunit of the SAGA complex, regulates biofilm formation, asexual development, and virulence of Aspergillus fumigatus. Appl Environ Microbiol doi:10.1128/AEM.01535-21:AEM0153521.
7. Chen Y, Le Mauff F, Wang Y, Lu R, Sheppard DC, Lu L, Zhang S. 2020. The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in Aspergillus fumigatus. mBio 11.
8. Huang J, Ma Z, Zhong G, Sheppard DC, Lu L, Zhang S. 2019. The mitochondrial thiamine pyrophosphate transporter TptA promotes adaptation to low iron conditions and virulence in fungal pathogen Aspergillus fumigatus. Virulence 10:234-247.
9. Zhang S, Chen Y, Ma Z, Chen Q, Ostapska H, Gravelat FN, Lu L, Sheppard DC. 2018. PtaB, a lim-domain binding protein in Aspergillus fumigatus regulates biofilm formation and conidiation through distinct pathways. Cell Microbiol 20.
10. Zhang S, Zheng H, Chen Q, Chen Y, Wang S, Lu L, Zhang S. 2017. The Lectin Chaperone Calnexin Is Involved in the Endoplasmic Reticulum Stress Response by Regulating Ca(2+) Homeostasis in Aspergillus nidulans. Appl Environ Microbiol 83.
11. Zheng H, Zhang S, Zhang S, Lu L. 2015. Riboflavin level manipulates the successive developmental sequences in Aspergillus nidulans. Curr Microbiol 70:637-42.
12. Zhang S, Zheng H, Long N, Carbo N, Chen P, Aguilar PS, Lu L. 2014. FigA, a putative homolog of low-affinity calcium system member Fig1 in Saccharomyces cerevisiae, is involved in growth and asexual and sexual development in Aspergillus nidulans. Eukaryot Cell 13:295-303.
实验室具有完善的真菌遗传和分子研究体系和科研平台，欢迎对真菌研究感兴趣的研究生报考，欢迎本科生科研训练和毕业设计。
联系方式：E-mail: szzhang@njnu.edu.cn
