个人简介

韩管助，南京师范大学生命科学学院教授、博士生导师，国家自然科学基金优秀青年科学基金获得者。主要从事病毒进化和多样性以及病原与宿主间互作进化方面的研究工作，共发表SCI收录论文80余篇，其中作为通讯作者（含共同）在Science、PNAS、Science Advances、Nature Communications、Molecular Biology and Evolution、Plant Cell、PLOS Pathogens、mBio等期刊发表论文60余篇，相关研究成果多次获得Nature Reviews Microbiology、Trends in Plant Science等期刊评述或推荐，并被收录入Principles of Virology等经典教材。担任Mobile DNA、Virologica Sinica、Journal of Systematics and Evolution等期刊编委。

教育和工作经历

2015至今：南京师范大学，生命科学学院，教授

2010-2014：美国亚利桑那大学，生态与进化生物学专业，博士

2005-2009：山东师范大学，生物技术专业，学士

研究方向

病原微生物正严重威胁着全球公共卫生健康、粮食安全以及社会经济发展。我们实验室主要利用进化生物学、基因组学、分子生物学、人工智能等多学科交叉融合方法来研究病原进化以及病原与宿主间互作进化，主要研究方向包括：

·病毒起源、进化和多样性；

·新发传染病溯源、进化和预测；

·病原与宿主间互作进化；

·作物抗病进化和智能设计。

代表性论文（*通讯作者）

1.Wu Z, Han GZ*. (2026). A gradient green-beard gene in fission yeast. EMBO Reports 27: 1904-1917.

2.Wu Z, Liu X, Xu H, Han GZ*. (2026). Pseudogene revival drives repeated adaptation in fission yeast. Molecular Biology and Evolution 43: msag120.

3.Wang Y, Xu H, He Q, Wu Z, Gong Z*, Han GZ*. (2026). Recombination shapes the diversification of the wtf meiotic drivers. eLife 13: RP100638.

4.Lu P*, Zhang G, Li J, Gong Z, Wang G, Dong L, Zhang H, Guo G, Su M, Wang K, Wang Y, Zhu K, Wu Q, Chen Y, Li M, Huang B, Li B, Li W, Dong L, Hou Y, Cui X, Fu H, Qiu D, Yuan C, Li H*, Zhou JM*, Han GZ*, Chen Y*, Liu Z*. (2025). A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens. Science 387: 1418-1424.（Developmental Cell、Trends in Plant Science、SCIENCE CHINA Life Sciences、Plant Communications等专文评述）

5.He Q, Liu Q, Gong Z, Han GZ*. (2025). Phylogenomics unveils the complex evolution of retroviruses in birds. Molecular Biology and Evolution 42: msaf171.

6.Gong Z*, Han GZ*. (2025). The cryptic diversity of hepadnavirus relatives. mBio 16: e0254125.

7.Wu Z, Chu L, Gong Z, Han GZ*. (2024). The making of a nucleic acid sensor at the dawn of jawed vertebrate evolution. Science Advances 10: eado7464.

8.Chu L, Gong Z, Wang W, Han GZ*. (2023). Origin of the OAS-RNase L innate immune pathway before the rise of jawed vertebrates via molecular tinkering. Proceedings of the National Academy of Sciences 120: e2304687120.

9.Wang J, Han GZ*. (2023). Genome mining shows that retroviruses are pervasively invading vertebrate genomes. Nature Communications 14: 4968.

10.Wang W, Han GZ*. (2023). A long-running arms race between APOBEC1 genes and retroviruses in tetrapods. Journal of Virology 97: e0179522.

11.Gong Z, Qi J, Hu M, Bi G, Zhou JM*, Han GZ*. (2022). The origin and evolution of a plant resistosome. Plant Cell 34: 1600-1620.（Plant Cell专文评述）

12.Wang J, Han GZ*. (2022). A missing link between retrotransposons and retroviruses. mBio 13: e00187-22.

13.Gong Z, Shao ZQ*, Chen JQ*, Han GZ*. (2022). Plant immune receptors evolved hand in hand. Nature Plants 8: 1138-1139. （News and Views文章）

14.Wang J, Han GZ*. (2021). Unearthing LTR retrotransposon gag genes co-opted in the deep evolution of eukaryotes. Molecular Biology and Evolution 38: 3267-3278.

15.Wang J, Han GZ*. (2021). A sister lineage of sampled retroviruses corroborates the complex evolution of retroviruses. Molecular Biology and Evolution 38: 1031-1039.

16.Zheng J, Wang J, Gong Z, Han GZ*. (2021). Molecular fossils illuminate the evolution of retroviruses following a macroevolutionary transition from land to water. PLOS Pathogens 17: e1009730.

17.Wang Q, Wang Y, Wang J, Gong Z, Han GZ*. (2021). Plants acquired a major retrotransposon horizontally from fungi during the conquest of land. New Phytologist 232: 11-16.

18.Gong Z, Han GZ*. (2021). Flourishing in water: the early evolution and diversification of plant receptor-like kinases. Plant Journal 106: 174-184.

19.Wang W, Han GZ*. (2021). Pervasive positive selection on virus receptors driven by host-virus conflicts in mammals. Journal of Virology 95: e01029-21.

20.Wang J, Han GZ*. (2020). Frequent retroviral gene co-option during the evolution of vertebrates. Molecular Biology and Evolution 37: 3232-3242.

21.Wang W, Zhao H, Han GZ*. (2020). Host-virus arms races drive elevated adaptive evolution in viral receptors. Journal of Virology 94: e00684-20.（Journal of Virology专文评述）

22.Han GZ*. (2019). Origin and evolution of the plant immune system. New Phytologist 222: 70-83.（特邀Tansley Review）

23.Wang J, Gong Z, Han GZ*. (2019). Convergent co-option of the retroviral gag gene during the early evolution of mammals. Journal of Virology 93: e00542-19.

24.Xu X, Zhao H, Gong Z, Han GZ*. (2018). Endogenous retroviruses of non-avian/mammalian vertebrates illuminate diversity and deep history of retroviruses. PLOS Pathogens 14: e1007072.（Nature Reviews Microbiology专文评述）

25.Gong Z, Han GZ*. (2018). Insect retroelements provide novel insights into the origin of hepatitis B viruses. Molecular Biology and Evolution 35: 2254-2259.（Molecular Biology and Evolution封面推荐）

26.Gong Z, Han GZ*. (2018). Euphyllophyte paleoviruses illuminate hidden diversity and macroevolutionary mode of Caulimoviridae. Journal of Virology 92: e02043-17.

27.Gao Y, Wang W, Zhang T, Gong Z, Zhao H, Han GZ*. (2018). Out of water: the origin and early diversification of plant R-genes. Plant Physiology 177: 82-89.（Plant Physiology、Trends in Plant Science等专文评述）

28.Wang C, Liu Y, Li S*, Han GZ*. (2015). Insights into the origin and evolution of plant hormone signaling machinery. Plant Physiology 167: 872-886.（Plant Physiology专文评述）

29.Han GZ*, Worobey M*. (2015). A primitive endogenous lentivirus in a colugo: insights into the early evolution of lentiviruses. Molecular Biology and Evolution 32: 211-215.

30.Worobey M*, Han GZ, Rambaut A*. (2014). A synchronized global sweep of the internal genes of modern avian influenza virus. Nature 508: 254-257.（Nature Reviews Microbiology、Nature等专文评述）

31.Worobey M*, Han GZ, Rambaut A. (2014). The genesis and pathogenesis of the 1918 influenza pandemic. Proceedings of the National Academy of Sciences 111: 8107-8112.（PNAS专文评述）

32.Han GZ*, Worobey M*. (2012). An endogenous foamy-like viral element in the coelacanth genome. PLOS Pathogens 8: e1002790. （收录入Principles of Virology等教材）

33.Han GZ*, Worobey M*. (2012). Endogenous lentiviral elements in the weasel family (Mustelidae). Molecular Biology and Evolution 29: 2905-2908.

34.Han GZ*, Worobey M*. (2012). An endogenous foamy virus in the aye-aye (Daubentonia madagascariensis). Journal of Virology 86: 7696-7698.

联系方式

        邮箱：guanzhu@@njnu.edu.cn（发邮件时请去掉一个@）

我们实验室长期招聘具有病毒学、免疫学、细胞生物学、人工智能等背景的博士后，欢迎随时联系我们！