南京师范大学生命科学学院微生物与生物技术研究所教授，博士生导师。获得国家海外高层次青年人才引进计划、江苏省特聘教授、江苏省杰出青年基金。主要从事植物病毒学、病毒与寄主互作机制的研究，主要研究工作发表在PNAS, PLOS Biology, Molecular Plant, Autophagy, PLOS Pathogens, Journal of Virology, Current Opinion in Virology等学术期刊。
课题组利用大豆花叶病毒（soybean mosaic virus, SMV）以及烟草坏死病毒A中国大豆分离物（tobacco necrosis virus-A Chinese soybean isolate, TNV-Ac）为实验对象，通过遗传学、分子生物学、细胞生物学的技术手段，理解病毒致病性与植物抗病机制。课题组对实验室成员进行病毒学知识和实验能力的全面培养与训练，欢迎具有生命科学相关学科背景的本科生、研究生和博士加入，进行本科毕业设计、研究生学习或博士后工作。
教育背景与工作经历：
2017.1至今南京师范大学生命科学学院教授；
2014.7– 2016.9美国肯塔基大学植物病理系博士后研究员；
2007.8– 2014.6美国肯塔基大学植物病理系博士研究助理，获博士学位；
2005.7– 2007.3中国农业大学农业生物技术国家重点实验室科研助理；
2001.9– 2005.6中国农业大学生物学院生物科学理科基地班，获理学学士学位。
发表论文:
1. Hong X#, Li S#, Cheng X, Zhi H, Yin J*, Xu K*. 2024, Searching for plant NLR immune receptors conferring resistance to potyviruses. The Crop Journal, 12(1), 28-44
2. Li C#, Yang W#, Zhang Y#, Zhu F, Qiu Y, Du L, Lin F, Lan Y, Xu K*, Zhou T*. 2024, Investigation and characterization of rice dwarfing epidemic caused by southern rice black-streaked dwarf virus in Jiangsu in 2023. Virology, 593, 110027
3. Gu C, Yu X, Tang X, Gong L, Tan J, Zhang Y, Zheng H, Wang Z, Zhang C, Zhu Y, Zhou Z, Yu H, Xu K*, Duan J*, Gu X*, Yang Y*. 2023, Lycium barbarum L.-Derived miR162a Functions on Osteoporosis through Directly Promoting Osteoblast Formation. Engineering, DOI: 10.1016/j.eng.2023.09.007
4. Yin J, Hu Z, Xu S, Hong X, Qiu Y, Cheng X, Wang L, Sheng W, Zhi H, Li K*, Xu K*. 2023, Leafhopper transmits soybean stay‑green associated virus to leguminous plants. Phytopathology Research 5, 17
5. Yin J, Tan J, Luo S, Hong X, Zhang Y, Qiu Y, Latif M, Xu K. 2023, First report of clover yellow vein virus infecting Pisum sativum in China. Journal of Plant Pathology 105, 1183
6. Liu H#, Zheng H#, Xiang W#, Song Y, Li B, Yin J, Liu M, Liu X, Wang L, Yang S*, Xu K*, Zhi H*. 2023, Construction and characterization of the infectious cDNA clone of the prevalent Chinese strain SC3 of soybean mosaic virus. Phytopathology Research 5, 9
7. Wang H#, Zhang J#, Liu H#, Wang M, Dong Y, Zhou Y, Wong S, Xu K*, Xu Q*. 2023, A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector. Autophagy 19 (4), 1128-1143
8. Zhang K, Hua Y, Feng C, Gu TX, Guo X, Zhuang X, Xu K. 2022, First report of cucumber mosaic virus satRNA in Salvia miltiorrhiza in China. Journal of Plant Pathology 105, 365–366
9. Yin J, Hong X, Luo S, Tan J, Zhang Y, Qiu Y, Latif MF, Gao T, Yu H, Bai J, Li S, Xu K. 2022, The Characterization of the Tobacco-Derived Wild Tomato Mosaic Virus by Employing Its Infectious DNA Clone. Biology 11(10), 1467
10. Yin J#, Wang L#, Jin T, Nie Y, Liu H, Qiu Y, Yang Y, Li B, Zhang J, Wang D, Li K, Xu K*, Zhi H*. 2021, A cell wall-localized NLR confers resistance to Soybean mosaic virus by recognizing viral-encoded cylindrical inclusion protein. Molecular Plant 14 (1), 1881-1900.
11. Zhang W, Qiu Y, Zhou L, Yin J, Wang L, Zhi H, Xu K*. 2021, Development of a Viral RdRp-Assisted Gene Silencing System and Its Application in the Identification of Host Factors of Plant (+) RNA Virus. Frontiers in Microbiology 12: 682921.
12. Zhang J#, Qiu Y#, Xu K*. 2020, Characterization of GFP-AtPEN1 as a marker protein for extracellular vesicles isolated from Nicotiana benthamiana leaves. Plant signaling & behavior 15 (9), 1791519
13. Qiu Y, Xu K*. 2020, Functional studies of the coronavirus nonstructural proteins. STEMedicine 1 (2), e39-e39
14. Feng Z, Xu K*, Kovalev N, Nagy PD*. 2019, Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus. PLoS Pathogens. 15 (1), e1007530.
15. Yang M, Li Z, Zhang K, Zhang X, Zhang Y, Wang X, Han C, Yu J, Xu K*, Li D*. 2018, Barley stripe mosaic virus interacts with glycolate oxidase and inhibits peroxisomal ROS production to facilitate virus infection. Molecular Plant 11 (2), 338-341.
16. Xu K, Nagy PD. 2017, Sterol-binding by the tombusviral replication proteins is essential for replication in yeast and plants. Journal of Virology 91 (7), e01984-16.
17. Xu K, Nagy PD. 2016, Enrichment of phosphatidylethanolamine in viral replication organelles via co-opting the Rab5 endosomes by a positive-strand RNA virus. PLoS Biology 14(10): e2000128.
18. Nawaz-Ul-Rehman MS#, Prasanth KR#, Xu K#, Sasvari Z#, Kovalev N, de Castro Martin IF, Barajas D, Risco C, Nagy PD. 2016, Viral replication protein inhibits cellular cofilin actin depolymerization factor to regulate the actin network and promote viral replicase assembly. PLoS Pathogens 12(2):e1005440.
19. Xu K, Nagy PD. 2015, RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes. Proceedings of the National Academy of Sciences USA, 112(14): E1782-E1791.
20. Xu K#, Lin JY#, Nagy PD. 2014, The Hop-like stress induced protein 1 co-chaperone is a novel cell-intrinsic restriction factor for mitochondrial tombusvirus replication. Journal of Virology, 88(16):9361-9378.
21. Xu K, Huang TS, Nagy PD. 2012, Authentic in vitro replication of two tombusviruses in isolated mitochondrial and endoplasmic reticulum membranes. Journal of Virology, 86(23):12779-12794.
22. Xu K, Nagy PD. 2014, Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication. Current Opinion in Virology, 9: 119-126.
23. Xu K, Nagy PD. 2010, Dissecting virus-plant interactions through proteomics approaches. Current Proteomics, 7(4): 316-327.
24. Xu K, Yoshida R. 2010, Statistical analysis on detecting recombination sites in DNA-β satellites associated with old world geminiviruses. Frontiers in Psychiatry, 1: 138. B
25. Zhang K, Zhuang X, Dong Z, Xu K, Chen X, Liu F, He Z. 2021, The dynamics of N6-methyladenine RNA modification in interactions between rice and plant viruses. Genome Biology 22 (1), 1-36.
26. Zhang X#, Wang X, Xu K, Jiang Z, Dong K, Xie X, Zhang H, Yue N, Zhang Y, Wang X, Han C, Yu J, Li D*. 2021, The serine/threonine/tyrosine kinase STY46 defends against hordeivirus infection by phosphorylating γb protein. Plant Physiology, 12;186(1):715-730.
27. Wang X, Cao X, Liu M, Zhang R, Zhang X, Gao Z, Zhao X, Xu K, Li D, Zhang Y. 2018, Hsc70-2 is required for Beet black scorch virus infection through interaction with replication and capsid proteins. Scientific Reports,14;8(1):4526.
28. Zhang X, Dong K, Xu K, Zhang K, Jin X, Yang M, Zhang Y, Wang X, Han C, Yu J, Li D. 2018, Barley stripe mosaic virus infection requires PKA-mediated phosphorylation of γb for suppression of both RNA silencing and the host cell death response. New Phytologist 218(4):1570-1585.
29. Sasvari Z, Kovalev N, Gonzalez PA, Xu K, Nagy PD. 2018, Assembly-hub function of ER-localized SNARE proteins in biogenesis of tombusvirus replication compartment. PLoS Pathogens, 14(5):e1007028
30. Nagy PD, Pogany J, Xu K. 2016. Cell-free and cell-based approaches to explore the roles of host membranes and lipids in the formation of viral replication compartment induced by Tombusviruses. Viruses, 8(3):68
31. Barajas D, Xu K, Sharma M, Wu CY, Nagy PD. 2014, Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology, 471:72-80.
32. Barajas D, Xu K, de Castro Martín IF, Sasvari Z, Brandizzi F, Risco C, Nagy PD. 2014, Co-opted oxysterol-binding ORP and VAP proteins channel sterols to RNA virus replication sites via membrane contact sites. PLoS Pathogens, 10(10):e1004388.
33. Shah Nawaz-ul-Rehman M, Martinez-Ochoa N, Pascal H, Sasvari Z, Herbst C, Xu K, Baker J, Sharma M, Herbst A, Nagy PD. 2012, Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C. Journal of Virology, 86(17): 9384-9395.
34. Pathak KB, Pogany J, Xu K, White KA, Nagy PD. 2012, Defining the roles of cis-acting RNA elements in tombusvirus replicase assembly in vitro. Journal of Virology, 86(1):156-171.
35. Li Z, Pogany J, Panavas T, Xu K, Esposito AM, Kinzy TG, Nagy PD. 2009, Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor. Virology, 385(1):245-260.
36. Niu S, Wang B, Guo X, Yu J, Wang X, Xu K, Zhai Y, Wang J, Liu Z., 2009, Identification of two RNA silencing suppressors from banana bunchy top virus. Archives in Virology, 154(11):1775-1783.
承担科研项目：
1. 国家自然科学基金面上项目（2018-2021）
2. 江苏省自然科学基金杰出青年项目（2018-2021）
3. 江苏省双创团队项目（2021-2024）
4. 国家自然科学基金面上项目（2024-2027）
学术团体：
1. 江苏省植物病理学会理事
2. 江苏省生物技术协会理事
3. 中国植物病理学会会员
4. 江苏省植物生理学会会员
5. 美国病毒学会会员
联系方式：
邮件：xukai@njnu.edu.cn
通讯地址：江苏省南京市文苑路1号，南京师范大学生命科学院，邮编：210023。
