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袁生

袁生教授,南京师范大学博士生导师,1997年北京师范大学获得博士学位,2001年美国Pennsylvania State University博士后出站。南京师范大学生物学一级学科及微生物学科带头人,微生物学国家双语教学示范课程、江苏省精品课程主持人。兼任中国微生物学会常务理事,中国微生物学会教育工作委员会副主任,江苏省微生物学会理事长,江苏省食用菌协会常务理事兼专家委员会副主任。江苏省有突出贡献的中青年专家和“六大人才高峰”计划专家。先后获得省科技进步奖和省优秀教学成果奖五次。主编《微生物学》教材入选国家十一五规划教材和省精品教材。

主要研究方向为微生物生长代谢调控研究,目前主要研究担子菌子实体生长发育的分子机制及其多糖水解酶在细胞壁重建过程中的作用,开发新型酶制剂。先后主持10个国家自然科学项目和2个国家十一五科技攻关项目,发表研究论文100多篇。

 

微生物生长代谢调控的分子生物学研究代表作(*通讯作者):

1. Yuan SJ Wu and D Cosgrove (2001). A Fungal Endoglucanase with Plant Wall Extension Activity. Plant Physiol., 127, 324-333.
2. Zhao Q, S. Yuan*, X. Wang, Y. Zhang, H. Zhu, C. Lu (2008). Restoration of mature etiolated cucumber hypocotyl cell wall susceptibility to expansin by pretreatment with fungal pectinases and EGTA in vitro. Plant Physiol. 2008; 147(4):1874-1885.
3. Wang J, S Yuan* and SB Jiang (2006). The Ribosomal Protein L32-2 (RPL32-2) of S. Pombe Exhibits a Novel Extraribosomal Function by Acting As a Potential Transcriptional Regulator. FEBS letters
5801827-1832.
4. Wang G., L. Lu,*, C.-Y. Zhang, A. Singapuri, and S. Yuan (2006). Calmodulin concentrates at the apex of growing hyphae and localizes to the Spitzenkörper in Aspergillus nidulans. Protoplasma, 228:159-166.
5. Zhao Q, S Yuan*, Zhang Y, H Zhu, C Dai, F Yang, F Han (2007). Expression, Purification and Characterization of Pectate Lyase A from Aspergillus nidulans in Escherichia coli. World J Microbiol Biotechnol, 23:1057-1064.

 

微生物代谢调控与药物合成研究代表作(*通讯作者):
1. Jiang J.-R., S. Yuan*, J.-F. Ding , S-C Zhu, H.-D. Xu, T. Chen, X.-D Cong, W.-P. Xu, H. Ye, Y-J Dai (2008) Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. Applied Microbiology and Biotechnology, DOI 10.1007/s00253-008-1683-z, on line.
2. Yue H, S Yuan*, X Cong (2007). Biotransformation Of Puerarin Into 3
-Hydrooxypuerarin By Trichoderma harzianum NJ01. Enzyme and Microbial Technology, 40594-597.
3. Dai Y-J, S Yuan*, F Ge, T Chen, S-C Xu, J-P Ni (2006). Microbial Hydroxylation of Imidacloprid for Synthesis of Highly Insecticidal Olefin Imidacloprid. Applied Microbiology and Biotechnology, 71
927-934.
4. Dai Y-J, T Chen, F Ge, Y Huan, S Yuan*, and F Zhu (2007). Enhanced hydroxylation of imidacloprid by Stenotrophomonas maltophilia upon addition of sucrose. Applied Microbiology and Biotechnology, 74, 995-1000.
5. Chen T., Dai Y.-J., Ding J.-F., Yuan S. *, Ni J.-P.(2008) N-demethylation of neonicotinoid insecticide acetamiprid by bacterium Stenotrophomonas maltophilia CGMCC 1.1788. Biodegradation.19(5): 651-658.