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余书勤

余书勤 教授。药学硕士研究生导师,生物学(生理专业)硕士研究生导师。

研究方向:以细胞膜上p-糖蛋白(p-gp)为切入点,围绕它的表达、细胞膜定位、线粒体功能、p-gp-ATP酶的相互作用,对抗癌药物与环境内分泌干扰物(EDCs)的吸收、分布与毒性进行探讨。以此为基础,主要在两个方向进行研究。在药学领域,研究方向为逆转癌症多药耐药(multidrug resistance, MDR)的新型纳米递药系统(nano-drug delivery system, NDDS)的生物效应与机理研究。在抗癌药物的靶向与共递药、细胞核递药以及MDR细胞内精准药物释放与逆转MDR方面进行探讨。在毒理学领域,对非离子型食品乳化剂促进增塑剂的吸收、毒性靶器官分布与毒效机理方面进行探讨。

发表论著:以通讯作者发表18篇SCI学术榜论著。单篇最高IF 7.50(发表时5.93),IF>3的论文14篇,平均IF>3.4。1 篇ESI高影响论文。 H因子=10。获得8项与新药有关的发明专利,其中3 项国际专利公开PCT。参与2 项新药研发被批准临床研究。

科研项目:作为负责人主持国家自然科学基金一项(在研)。作为子题负责人参与国家科技重大专项(新药创制)项目一项(完成)。

指导研究生:毕业人数28 人。近5 年来,其中1人获得国家奖学金。 2 人获得江苏省优秀硕士研究生论文 (2015年度,2016年度),4 人获得朱敬文奖学金, 3人获得校级优秀研究生毕业论文奖,7人次获得优秀毕业研究生。研究生毕业后多在大型制药公司与药物研发公司, 或高级中学工作。目前在培研究生6 人。

学术链接:作者:ORCID: 0000-0002-2824-4651。 ResearcherID: K-5982-2012。 ScopusID:55741364600。Google Scholar: https://xue.glgoo.net/scholar?hl=zh-CN&q=yushuqin%40njnu.edu.cn&btnG=&lr=

审稿人:Publons:1225510/

联系方式:通讯地址江苏省南京市栖霞区文苑路1号,南京师范大学生命科学学院47号信箱(210023),电话13805178158; Emailyushuqin@njnu.edu.cn

 

论著(仅列入作为通讯作者的论文,IF与分区为发表时)

  1. Xi Lin, Shun-Zhen Yan, Shan-Shan Qi, Qiao Xu, Shuang-Shuang Han, Ling-Yuan Gu, Ning Zhao, Shuang-Lin Chen*, Shu-Qin Yu*. Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A. Front. Pharmacol. 2017,00815 | doi: 10.3389/fphar.2017.00815 【SCI, IF: 4.40】
  2. Ling-Yuan Guo, Shu-Zhen Yan,  Qiang Li,  Qiao Xu,  Xi Lin, Shan-Shan Qi, Shu-Qin Yu*, Shuang-Lin Chen*. Poly(lactic-co-glycolic) acid nanoparticles improve oral bioavailability of hypocrellin A in rat.  RSC Adv., 2017,7, 42073-42082 【SCI, IF=3.15】
  3. Dan-Dan Zhang, Yan-Yan Kong, Jia-Hui Sun, Shao-Jie Huo, Min Zhou, Yi-Ling Gui, Shu-Qin Yu*, Qian Xu*. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. International Journal of Nanomedicine 2017;12:20181-2108 【SCI, IF=4.30, TOP】
  4. Hai-Tao Gao, Run Xu, Wei-Xin Cao, Liang-Liang Qian, Min Wang, Lingeng Lu, Qian Xu*, Shu-Qin Yu*, Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food and Chemical Toxicology, 2017;101:94-104 【SCI, IF=3.584】
  5. Ying-Ying Wang, Dan-Dan Zhang, Yan-Yan Kong, Luan-Luan Shao, Fen-Yi Zhang, Yu Gao, Xu Mu, Jie Wang, Hao-Fan Li, Shu-Qin Yu*, Qian Xu*. CS/PAA@TPGS/PLGA nanoparticles with intracellular pH-sensitives equential release for delivering drug to the nucleus of MDR cells. Colloids and Surfaces B: Biointerfaces 2016; 145:716-727 【SCI, IF=4.12】
  6. Wang Dong- Fang, Rong Wen-Ting, Lu Yu, Hou Jie, Qi Shan-Shan, Xiao Qing, Zhang Jue, You Jin, Shu-Qin Yu*, Xu Qian*. TPGS2k/PLGA nanoparticles for overcoming multidrug resistance by interfering mitochondria of human alveolar adenocarcinoma cells. ACS Applied Materials & Interfaces 2015; 7(7): 3888-3901 【SCI, IF=5.93,TOP】
  7. Lu Yu, Wang Ying-Ying, Yang Nan, Zhang Dan, Zhang Feng-Yi, Gao Hai-Tao, Rong Wen-Ting, Shu-Qin Yu*, Xu Qian. Food emulsifier polysorbate 80 increases intestinal absorption of di-(2-ethylhexyl) phthalate in rats. Toxicological Sciences 2014; 139 (2): 317-327【SCI, IF=4.50】
  8. Rong Wen-Ting, Lu Ya-Peng, Tao Qing, Guo Miao, Lu Yu, Ren Yong ,  Shu-Qin Yu*. Hydroxypropyl-sulfobutyl-β-cyclodextrin improves the oral bioavailability of edaravone by modulating drug efflux pump of enterocytes. Journal of Pharmaceutical Sciences 2014; 103(2): 730-742 【SCI, IF=3.3】
  9. Qi Shan-Shan, Lin Xi, Zhang Miao-Miao, Yan Shu-Zhen, Shu-Qin Yu*, Chen Shuang-Lin*.  Preparation and evaluation of hypocrellin A loaded poly(lactic-co-glycolic acid) nanoparticles for photodynamic therapy. RSC Advances 2014, 4 (75): 40085-40094  【SCI, IF=3.8】
  10. Ya-Peng Lu, Si-Yuan Liu, Yu Zhao, Li Zhu*, Shu-Qin Yu*. Complexation of Z-ligustilide with hydroxypropyl-b-cyclodextrin to improve stability and oral bioavailability. Acta Pharm 2014, 64:211-222 【SCI, IF=1.0】
  11. Guo Miao, Rong Wen-Ting, Hou Jie, Wang Dong-Fang, Lu Yu, Wang Ying, Shu-Qin Yu*, Xu Qian*.  Mechanisms on chitosan-coated poly (lactic-co-glycolic acid) nanoparticles for improving oral absorption of 7-ethyl-10-hydroxycamptothecin. Nanotechnology 2013; 24: 245101 (15pp) 【SCI, IF=3.90,TOP】
  12. Wang Ying, Guo Miao, Lu Yu, Ding Li-Ying, Ron Wen-Ting, Liu Ya-Qing, Song Fei-Fei, Shu-Qin Yu*. Alpha-tocopheryl polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro. Nanotechnology 2012; 23:495103 (14pp) 【SCI, IF=3.90,TOP】
  13. Chen Cheng, Xie Xiao-Xia, Zhou Qian, Zhang Feng-Yi, Wang Qiao-Lin, Liu Ya-Qing, Zou Yi-Na, Tao Qing, Ji Xue-Mei, Shu-Qin Yu*. EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide. Nanotechnology 2012; 23: 045104 (12pp) 【SCI, IF=3.90,TOP】
  14. Xu Qian, Wang Min, Shu-Qin Yu*, Tao Qing, Tang Meng*. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry. Analyst 2011; 136 (23): 5030-5037 【SCI, IF=3.90】
  15. Huang Xing-Xing, Zhou Cheng-Liang, Wang Hui, Chen Cheng, Shu-Qin Yu*, Xu Qian, Zhu Yin-Yan, Ren Yong. Pharmacokinetics, efficacy, and safety evaluation of docetaxel/hydroxypropyl-sulfobutyl-beta-cyclodextrin inclusion complex. AAPS PharmSciTech 2011; 12(2): 665-672 【SCI, IF=1.24】
  16. Xie Xiao-Xia, Tao Qing, Zou Yi-Na, Zhang Feng-Yi, Guo Miao, Wang Ying, Wang Hui, Zhou Qian, Shu-Qin Yu*. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. Journal of Agricultural and Food Chemistry 2011; 59 (17): 9280-9289 【SCI, IF=2.93,TOP】【ESI高被引论文】
  17. Wang Hui, Xie Xiao-Xia, Zhang Feng-Yi, Zhou Qian, Tao Qing, Zou Yi-Na, Chen Cheng, Shu-Qin Yu*. Evaluation of cholesterol depletion as a marker of nephrotoxicity in vitro for novel β-cyclodextrin derivatives. Food and Chemical Toxicology 2011; 49(6): 1387-1393【SCI, IF=2.80】
  18. Xu Guang-Lin, Yao Lin, Gong Zu-Nan, Zhang Shun-Quan, Shu-Qin Yu*. Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase. Journal of Ethnopharmacology 2005; 8 (1,2): 177-183【SCI, IF=2.50】
  19. Ying Wang, Miao Guo, Yu Lu, LiYing Ding, Shu-Qin Yu*. PLGA nanoparticles containing SN-38 for reversing multiple drug resistance of A549/DDP Cells. Journal Control Release 2013; 28:172(1):e67
  20. Miao Guo, Ying Wang, Wen-Ting Rong, Li-ying Ding, Shu-Qin Yu*. Chitosan-modified PLGA nanoparticles as drug delivery carrier for modulating P-glycoprotein of enterocytes. Journal Control Release 2013; 28:172(1):e112-3

发明专利(国际专利公开 PCT

  1. US8278437B2, Hydroxypropyl-sulfobutyl-beta-cyclodextrin, the preparation method, the analytical method, and the pharmacutical application thereof, 20121002
  2. US8426385B2, Pharmaceutical composition comprising cyclodextrin paclitaxel inclusion and preparation method thereof, 20130423
  3. US8481511B2, Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process, 20130709

 

科研项目:

  1. 主持:国家自然科学基金,非离子型食品乳化剂增加邻苯二甲酸酯类吸收的效应及机制研究 ,批准号81673214。
  2. 子题负责:国家科技重大专项(新药创制)项目,批准号2009ZX09103-44。