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余书勤

余书勤教授。药学(微生物与生化制药专业)研究生导师。生物学(生理学专业)研究生导师。

研究方向:以细胞膜上p-糖蛋白(p-gp)为切入点,围绕它的表达、细胞膜定位、线粒体功能、p-gp-ATP酶的相互作用,对抗癌药物与环境内分泌干扰物(EDCs)的吸收、分布与毒性进行探讨。以此为基础,主要在两个方向进行研究。在药学领域,研究方向为逆转癌症多药耐药(Multidrug resistance, MDR)的新型纳米递药系统(Nano-drug delivery system, NDDS)的生物效应与机理研究。在抗癌药物的靶向与共递药、细胞核递药以及MDR细胞内精准药物释放与逆转MDR方面进行探讨。在毒理学领域,对食品乳化剂与肠道微生物互作影响EDCs的吸收、毒性靶器官分布与毒效机理方面进行探讨。

科研成果:以通讯作者发表19篇SCI学术榜论著,包括6篇1区TOP, 7篇2区论文。单篇最高IF 7.50(发表时5.93)。1 篇ESI热点与高被引论文,1篇ESI高被引论文。获得8项与新药有关的发明专利,其中3 项国际专利公开PCT。参与2 项新药研发被批准临床研究。

科研项目:作为负责人主持国家自然科学基金一项(在研)。作为子题负责人参与国家科技重大专项(新药创制)项目一项(完成)。

指导研究生:毕业人数28人。近5 年来,其中1人获得国家奖学金。 2 人获得江苏省优秀硕士研究生论文 (2015年度,2016年度),4 人获得朱敬文奖学金, 3人获得校级优秀研究生毕业论文奖,7人次获得优秀毕业研究生。研究生毕业后多在大型制药公司与药物研发公司, 或高级中学工作。目前在培研究生7人。

学术链接:作者:ORCID:0000-0002-2824-4651。ResearcherID: K-5982-2012。ScopusID:55741364600。Google Scholar:https://xue.glgoo.net/scholar?hl=zh-CN&q=yushuqin%40njnu.edu.cn&btnG=&lr=审稿人:Publons:1225510/

联系方式:通讯地址江苏省南京市栖霞区文苑路1号,南京师范大学生命科学学院(210046),电话13805178158; Emailyushuqin@njnu.edu.cn

 

论著(仅列入作为通讯作者的论文,IF与分区为发表时)

 

  1. Shan-Shan Qi, Jia-Hui Sun, Hao-Han Yu, Shu-Qin Yu*. Co-delivery nanoparticles of anti-cancer drugs forimproving chemotherapy efficacy.Drug Delivery. 2017; 24(1):1909-1926【SCI, IF=6.40】
  2. Xi Lin, Shun-Zhen Yan, Shan-Shan Qi, Qiao Xu, Shuang-Shuang Han, Ling-Yuan Gu, Ning Zhao, Shuang-Lin Chen*,Shu-Qin Yu*. Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A. Frontiers in Pharmacology.2017;8:0815【SCI,IF=4.40】
  3. Ling-Yuan Guo, Shu-Zhen Yan,  Qiang Li,  Qiao Xu,  Xi Lin, Shan-Shan Qi, Shu-Qin Yu*, Shuang-Lin Chen*. Poly(lactic-co-glycolic) acid nanoparticles improve oral bioavailability of hypocrellin A in rat. RSC Advances.2017; 7: 42073-42082 【SCI, IF=3.15】
  4. Dan-Dan Zhang, Yan-Yan Kong, Jia-Hui Sun, Shao-Jie Huo, Min Zhou, Yi-Ling Gui, Shu-Qin Yu*, Qian Xu*. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. International Journal of Nanomedicine.2017;12:20181-2108 【SCI,IF=4.30, TOP】
  5. Hai-Tao Gao, Run Xu, Wei-Xin Cao, Liang-Liang Qian, Min Wang, Lingeng Lu, Qian Xu*,Shu-Qin Yu*, Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food and Chemical Toxicology. 2017;101:94-104【SCI, IF=3.584】【ESI热点论文/ ESI高被引论文】
  6. Ying-Ying Wang, Dan-Dan Zhang, Yan-Yan Kong, Luan-Luan Shao, Fen-Yi Zhang, Yu Gao, Xu Mu, Jie Wang, Hao-Fan Li, Shu-Qin Yu*, Qian Xu*. CS/PAA@TPGS/PLGA nanoparticles with intracellular pH-sensitives equential release for delivering drug to the nucleus of MDR cells. Colloids and Surfaces B: Biointerfaces. 2016; 145:716-727【SCI, IF=4.12】
  7. Wang Dong-Fang, Rong Wen-Ting, Lu Yu, Hou Jie, Qi Shan-Shan, Xiao Qing, Zhang Jue, You Jin,Shu-QinYu*, Xu Qian*. TPGS2k/PLGA nanoparticles for overcoming multidrug resistance by interfering mitochondria of human alveolar adenocarcinoma cells. ACS Applied Materials & Interfaces.2015; 7(7): 3888-3901 【SCI, IF=5.93,TOP】 
  8. Lu Yu, Wang Ying-Ying, Yang Nan, Zhang Dan, Zhang Feng-Yi, Gao Hai-Tao, Rong Wen-Ting, Shu-Qin Yu*, Xu Qian. Food emulsifier polysorbate 80 increases intestinal absorption of di-(2-ethylhexyl) phthalate in rats.Toxicological Sciences.2014: 139 (2): 317-327【SCI, IF=4.50】
  9. Rong Wen-Ting, Lu Ya-Peng, Tao Qing, Guo Miao, Lu Yu, Ren Yong , Shu-Qin Yu*.Hydroxypropyl-sulfobutyl-β-cyclodextrin improves the oral bioavailability of edaravone by modulating drug efflux pump of enterocytes. Journal of Pharmaceutical Sciences. 2014; 103(2): 730-742 【SCI, IF=3.3】
  10. Qi Shan-Shan, Lin Xi, Zhang Miao-Miao, Yan Shu-Zhen, Shu-Qin Yu*, Chen Shuang-Lin*.  Preparation and evaluation of hypocrellin A loaded poly(lactic-co-glycolic acid) nanoparticles for photodynamic therapy. RSC Advances.2014; 4 (75): 40085-40094  【SCI, IF=3.8】
  11. Ya-Peng Lu, Si-Yuan Liu, Yu Zhao, Li Zhu*, Shu-Qin Yu*. Complexation of Z-ligustilide with hydroxypropyl-b-cyclodextrin to improve stability and oral bioavailability. Acta Pharmaceutica.2014; 64:211-222 【SCI, IF=1.0】
  12. Guo Miao, Rong Wen-Ting, Hou Jie, Wang Dong-Fang, Lu Yu, Wang Ying, Shu-Qin Yu*, Xu Qian*.  Mechanisms on chitosan-coated poly (lactic-co-glycolic acid) nanoparticles for improving oral absorption of 7-ethyl-10-hydroxycamptothecin. Nanotechnology. 2013; 24: 245101 (15pp) 【SCI, IF=3.90,TOP】
  13. Wang Ying, Guo Miao, Lu Yu, Ding Li-Ying, Ron Wen-Ting, Liu Ya-Qing, Song Fei-Fei, Shu-Qin Yu*. Alpha-tocopheryl polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro. Nanotechnology.2012; 23:495103 (14pp) 【SCI, IF=3.90, TOP】
  14. Chen Cheng, Xie Xiao-Xia, Zhou Qian, Zhang Feng-Yi, Wang Qiao-Lin, Liu Ya-Qing, Zou Yi-Na, Tao Qing, Ji Xue-Mei, Shu-Qin Yu*. EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide. Nanotechnology. 2012; 23: 045104 (12pp) 【SCI, IF=3.90,TOP】
  15. Xu Qian, Wang Min, Shu-Qin Yu*, Tao Qing, Tang Meng*. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry. Analyst.2011; 136 (23): 5030-5037 【SCI, IF=3.90】
  16. Huang Xing-Xing, Zhou Cheng-Liang, Wang Hui, Chen Cheng, Shu-Qin Yu*, Xu Qian, Zhu Yin-Yan, Ren Yong. Pharmacokinetics, efficacy, and safety evaluation of docetaxel/hydroxypropyl-sulfobutyl-beta-cyclodextrin inclusion complex. AAPS PharmSciTech. 2011; 12(2): 665-672 【SCI, IF=1.24】
  17. Xie Xiao-Xia, Tao Qing, Zou Yi-Na, Zhang Feng-Yi, Guo Miao, Wang Ying, Wang Hui, Zhou Qian, Shu-Qin Yu*. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. Journal of Agricultural and Food Chemistry. 2011; 59 (17): 9280-9289 【SCI, IF=2.93, TOP】【ESI高被引论文】
  18. Wang Hui, Xie Xiao-Xia, Zhang Feng-Yi, Zhou Qian, Tao Qing, Zou Yi-Na, Chen Cheng, Shu-Qin Yu*. Evaluation of cholesterol depletion as a marker of nephrotoxicity in vitro for novel β-cyclodextrin derivatives. Food and Chemical Toxicology.2011; 49(6): 1387-1393【SCI, IF=2.80】
  19. Xu Guang-Lin, Yao Lin, Gong Zu-Nan, Zhang Shun-Quan, Shu-Qin Yu*. Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase.Journal of Ethnopharmacology.2005; 8 (1,2): 177-183【SCI, IF=2.50】
  20. Ying Wang, Miao Guo, Yu Lu, LiYing Ding, Shu-Qin Yu*. PLGA nanoparticles containing SN-38 for reversing multiple drug resistance of A549/DDP Cells. Journal Control Release.2013; 172(1):e67
  21. Miao Guo, Ying Wang, Wen-Ting Rong, Li-ying Ding, Shu-Qin Yu*. Chitosan-modified PLGA nanoparticles as drug delivery carrier for modulating P-glycoprotein of enterocytes. Journal Control Release.2013; 172(1):e112-3

发明专利(国际专利公开 PCT

  1. US8278437B2, Hydroxypropyl-sulfobutyl-beta-cyclodextrin, the preparation method, the analytical method, and the pharmacutical application thereof, 20121002
  2. US8426385B2, Pharmaceutical composition comprising cyclodextrin paclitaxel inclusion and preparation method thereof, 20130423
  3. US8481511B2, Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process, 20130709

 

科研项目:

  1. 主持:国家自然科学基金,非离子型食品乳化剂增加邻苯二甲酸酯类吸收的效应及机制研究 。批准号81673214。
  2. 子题负责:国家科技重大专项(新药创制)项目,一类以CD11b为靶的抗白细胞-内皮细胞粘附乳糖衍生物候选药物研究。批准号2009ZX09103-44。