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余书勤

余书勤教授

研究方向:以细胞膜上p-糖蛋白(p-gp)为切入点,围绕它的表达、细胞膜定位、线粒体功能、p-gp-ATP酶的相互作用,对抗癌药物与环境内分泌干扰物(EDCs)的吸收、分布与毒性进行探讨。以此为基础,主要在两个方向进行研究。在药学领域,研究方向为逆转癌症多药耐药(Multidrug resistance, MDR)的新型纳米递药系统(Nano-drug delivery system, NDDS)的生物效应与机理研究。在抗癌药物的靶向与共递药、细胞核递药以及MDR细胞内精准药物释放与逆转MDR方面进行探讨。在食品与环境毒理学领域,对食品乳化剂与肠道微生物互作影响EDCs的吸收、毒性靶器官分布与毒效机理方面进行探讨。

科研成果:2011年以来,以通讯作者发表30余篇SCI论著,单篇最高IF 11.4135 分以上12篇。获得3 项国际专利公开PCTESI高被引论文1篇。

科研项目:作为负责人主持完成国家自然科学基金一项。作为子题负责人完成国家科技重大专项(新药创制)项目一项。

研究生培养:毕业人数30人。近5 年来,其中1人获得国家奖学金。 2 人获得江苏省优秀硕士研究生论文 (2015年度,2016年度)。研究生毕业后多在药物研发公司与高级中学工作。

学术链接:作者:ORCID:0000-0002-2824-4651ResearcherID: K-5982-2012ScopusID55741364600。审稿人:Publons1225510/

联系方式:通讯地址江苏省南京市栖霞区文苑路1号,南京师范大学生命科学学院(210046)电话13805178158; Emailyushuqin@njnu.edu.cn

代表性论著【药物递送方向】

  1. Shan-Shan Qi, Ling-Yuan Guo, Shu-Zhen Yan, Robert J. Lee, Shu-Qin Yu*, Shuang-Lin Chen*. Hypocrellin abased photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway. ActaPharmaceuticaSinica B 2019;9(2):279-293IF=11.413
  2. Wang Dong-Fang, Rong Wen-Ting, Lu Yu, HouJie, Qi Shan-Shan, Xiao Qing, Zhang Jue, You Jin,Shu-QinYu*, XuQian*. TPGS2k/PLGA nanoparticles for overcoming multidrug resistance by interfering mitochondria of human alveolar adenocarcinoma cells. ACS Applied Materials & Interfaces.2015; 7(7): 3888-3901IF=9.229 
  3. Qiu-Ping Feng, Yu-Ting Zhu, Yi-Zhen Yuan, Wen-Jie Li, Hao-Han Yu, Meng-Yuan Hu, Su-Yun Xiang*, Shu-Qin Yu*. Oral administration co-delivery nanoparticles of docetaxel and bevacizumab for improving intestinal absorption and enhancing anticancer activity. Materials Science & Engineering C 2021;124:112039IF=7.328
  4. Chong Ye, Wen-Jie Li, Hao-Han Yu, Qiu-Ping Feng, Xiu Wu, Yu-Ting Zhu, Meng-Yuan Hu, Su-Yun Xiang*, Shu-Qin Yu*.Binary blended co-delivery nanoparticles with the characteristics of precise pH-responsive acting on tumor microenvironment.Materials Science & Engineering C 2020;117:111370IF=7.328
  5. Ling-Yuan Guo, Shu-Zhen Yan, Xin Tao, Qing Yang, Qiang Li, Tian-Shu Wang, Shu-Qin Yu*,Shuang-Lin Chen*. Evaluation of Hypocrellin A-loaded Lipase Sensitive Polymer Micelles for Intervening methicillin-resistant Staphylococcus Aureus Antibiotic-resistant Bacterial Infection. Materials Science & Engineering C 2020;106:110230IF=7.328

代表性论著【食品与环境毒理方向】

  1. Hai-Tao Gao, Run Xu, Wei-Xin Cao, Liang-Liang Qian, Min Wang, Lingeng Lu, QianXu*,Shu-Qin Yu*, Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food and Chemical Toxicology. 2017;101:94-104IF=6.023
  2. Xie Xiao-Xia, Tao Qing, Zou Yi-Na, Zhang Feng-Yi, Guo Miao, Wang Ying, Wang Hui, Zhou Qian, Shu-Qin Yu*. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms.Journal of Agricultural and Food Chemistry. 2011; 59 (17): 9280-9289 IF=5.279】【ESI高被引论文】
  3. Lu Yu, Wang Ying-Ying, Yang Nan, Zhang Dan, Zhang Feng-Yi, GaoHai-Tao, Rong Wen-Ting, Shu-Qin Yu*, XuQian. Food emulsifier polysorbate 80 increases intestinal absorption of di-(2-ethylhexyl) phthalate in rats.Toxicological Sciences.2014: 139 (2): 317-327SCI, IF=4.849
  4. Yu-Ting Zhu, Yi-Zhen Yuan, Qiu-Ping Feng, Meng-Yuan Hu, Wen-Jie Li, Xiu Wu, Su-Yun Xiang*,Shu-Qin Yu*. Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier. Toxicology and Applied Pharmacology 2021; 414:115411IF=4.219
  5. Shao-JieHuo, Xiu Wu, Chong Ye, Meng-Yuan Hu, Wen-Jie Li, Ling-Ling Zhang, Su-Yun Xiang*, Shu-Qin Yu*, In Situ fluorescence tracking toxic metabolite mono-2-ethylhexyl phthalate (MEHP) of di-(2-ethylhexyl) phthalate (DEHP) in HeLacells. Chem Res Toxicol. 2019, 32, 2006−2015IF=3.739

发明专利(国际专利公开 PCT

  1. Yong Ren, Xue-Qin Ma, Shu-Qin Yu, Xia-Dong-Sun.Hydroxypropyl-sulfobutyl-beta-cyclodextrin, the preparation method, the analytical method, and the pharmacutical application thereof. Patent No: US82784372B2, Application No: 12/092273, Publication Date: 20070510
  2. Yong Ren, Jing-FengGao, Shu-Qin Yu, Ling Wu. Pharmaceutical composition comprising cyclodextrin paclitaxel inclusion and preparation method thereof, Patent No: US8426385B2, Application No: 12/440792, Publication date: 20130423
  3. Yong Ren, Jing-FengGao, Shu-Qin Yu, Ling Wu. Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process, Patent No: US8481511B2, Application No: 12/440942, Publication date: 20130709