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于海佳

博士,教授。
邮件:yuhaijia@njnu.edu.cn
通讯地址:江苏省南京市文苑路1号,南京师范大学生命科学院,邮编:210023

教育和工作经历:

2017年12月至今,南京师范大学生命科学学院分子细胞生物学研究所,教授;
2009年10月-2017年8月,美国科罗拉多大学博尔德分校分子细胞发育生物系,博士后研究助理;
2003年9月-2009月1月,中国科学院长春应用化学研究所化学生物学实验室,获博士学位;
1999年9月-2003年6月,东北师范大学,获学士学位。

研究领域与方向:

糖稳态维持的调控机制;
神经递质分泌过程的分子机理;
细胞内膜接触位点和细胞间通讯的功能研究。

承担科研项目:

国家自然科学基金面上项目 (2019-2022)
国家自然科学基金重大研究计划培育项目 (2019-2021)
江苏省特聘教授科研启动(2018-2020)

学术会员:
美国科学促进会、生物化学与分子生物学会会员 

论文著作:

1.    Chong Shen#, Yinghui Liu#, Haijia Yu*, Daniel R. Gulbranson, Igor Kogut, Ganna Bilousova, Chen Zhang, Michael H. B. Stowell, Jingshi Shen*, The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis,J. Biol. Chem., 2018, 293,18309-18317. ( #共同一者,*通讯作者)
2.    Haijia Yu*, Lauren Crisman, Michael H. B. Stowell, and Jingshi Shen*, Functional reconstitution of intracellular vesicle fusion using purified SNAREs and Sec1/Munc18 (SM) proteins. Methods Mol. Biol. 2018, 1860, 237-249. 
3.    Haijia Yu, Chong Shen, Yinghui Liu, Bridget L. Menasche, Yan Ouyang, Michael H. B. Stowell*, and Jingshi Shen*,SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins,Proc. Natl. Acad. Sci. U S A, 2018, 115, E8421-8429. 
4.    Daniel R. Gulbranson, Eric M. Davis, Brittany A. Demmitt, Yan Ouyang, Yihong Ye, Haijia Yu*, Jingshi Shen*, RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc. Natl. Acad. Sci. U S A, 2017, 114, E8224-E8233. 
(Faculty of 1000推荐点评)
5.    Haijia Yu, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen*,Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites,Proc. Natl. Acad. Sci. U S A, 2016, 113, 4362-4367. 
(Faculty of 1000推荐点评)
6.    Chong Shen#, Shailendra S. Rathore#, Haijia Yu#, Daniel R. Gulbranson, Rui Hua, Chen Zhang, Nathan E. Schoppa, and Jingshi Shen*,The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis, Nat. Commun., 2015, 6, 8852. 
7.    Haijia Yu#, Shailendra S. Rathore#, Chong Shen, Yinghui Liu, Yan Ouyang, Michael H. Stowell, Jingshi Shen*, Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding, J. Am. Chem. Soc., 2015, 137, 12873-12883. 
8.    Haijia Yu, Shailendra S. Rathore, Daniel R. Gulbranson, Jingshi Shen*, The N- and C-terminal domains of tomosyn play distinct roles in SNARE binding and fusion regulation, J. Biol. Chem., 2014, 289, 25571-25580. 
9.    Haijia Yu, Shailendra S. Rathore, Jamie A. Lopez, Eric M. Davis, David E. James, Jennifer L. Martin, Jingshi Shen*, Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins, Proc. Natl. Acad. Sci. U S A, 2013, 110, E3271-3280. 
(同期PNAS杂志专题评论: Yeon-Kyun Shin, Two gigs of Munc18 in membrane fusion. Proc. Natl. Acad. Sci. U S A, 2013, 110, 14116-14117.)
10.    Haijia Yu, Shailendra S. Rathore, Eric M Davis, Yan Ouyang, Jingshi Shen*, Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner, Mol. Biol. Cell., 2013, 24, 1176-1184. 
11.    Haijia Yu, Shailendra S. Rathore, Jingshi Shen*, Synip Arrests Soluble N- Ethylmale imide-sensitive Factor Attachment Protein Receptor (SNARE)-dependent Membrane Fusion as a Selective Target Membrane SNARE-binding Inhibitor,J. Biol. Chem., 2013, 288,18885-18893. 
12.    Haijia Yu#, Meng Li#, Gongping Liu#, Jie Geng, Jianzhi Wang, Jinsong Ren, Chuanqi Zhao, Xiaogang Qu*, Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide, Chem. Sci., 2012, 3, 3145-3153. 
13.    Shailendra S. Rathore, Eric G. Bend, Haijia Yu, Marc Hammarlund, Erik M. Jorgensen, Jingshi Shen*, Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex, Proc. Natl. Acad. Sci. U S A, 2010, 107, 22399-22406. 
14.    Haijia Yu, Chuanqi Zhao, Yong Chen, Manliang Fu, Jinsong Ren, Xiaogang Qu*, DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity, J. Med. Chem., 2010, 53, 492–498. 
15.    Haijia Yu, Xiaohui Wang, Manliang Fu, Jinsong Ren, Xiaogang Qu*, Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res., 2008, 36, 5695-5703. 
16.    Haijia Yu, Jinsong Ren, Jonathan B. Chaires, Xiaogang Qu*, Hydration of Drug-DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin, J. Med. Chem., 2008, 51, 5909–5911. 
17.    Haijia Yu, Jinsong Ren, Xiaogang Qu*, Different Hydration Changes Accompanying Copper and Zinc Binding to Amyloid β-Peptide: Water Contribution to Metal Binding, ChemBioChem, 2008, 9, 879-882. 
18.    Jie Geng, Haijia Yu, Jinsong Ren, Xiaogang Qu*, Rapid label-free detection of metal-induced Alzheimer's amyloid beta-peptide aggregation by electrochemical method, Electrochem. commun., 2008, 10, 1797-1800. 
19.    Haijia Yu, Jinsong Ren, Xiaogang Qu*, Time-Dependent DNA Condensation Induced by Amyloid β-Peptide, Biophys. J., 2007, 92, 185-191. 
20.    Haiyuan Zhang, Haijia Yu, Haixia Xu, Jinsong Ren, Xiaogang Qu*, Structural diversity of lanthanide-amino acid complexes under near physiological pH conditions and their recognition of single-stranded DNA, Polyhedron, 2007, 26, 5250-5256. 
21.    Huixin Bao, Xiaohui Wang, Haijia Yu, Manliang Fu, Xiaogang Qu*,Yongchen Zheng, Jinsong Ren, Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs, Chem. Phys. Lett., 2007, 436, 252-257. 
22.    Haiyuan Zhang, Haijia Yu, Jinsong Ren, Xiaogang Qu*, Reversible B/Z-DNA transition under the low salt condition and non-B-form polydApolydT selectivity by a cubane-like europium-L-aspartic acid complex, Biophys. J., 2006, 90, 3203-3207. 
23.    Haiyuan Zhang, Haijia Yu, Jinsong Ren, Xiaogang Qu*, PolydA and polyrA self-structured by a europium and amino acid complex, FEBS Lett., 2006, 580, 3726-3730.