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于海佳

博士,教授、博士生导师。获江苏特聘教授、江苏省杰出青年基金、江苏省六大人才高峰高层次人才项目、南京师范大学中青年领军人才项目资助。分子细胞生物学研究所所长。以第一或通讯作者在PNASDevelopmental CellCell ReportsJournal of Biological ChemistryJACSNucleic Acids ResearchChemical Science等杂志上发表论文20多篇。主要研究兴趣为膜运输及相关疾病的分子机理。

 

教育和工作经历

 

201712月至今,南京师范大学生命科学学院分子细胞生物学研究所,教授;

200910-20178月,美国科罗拉多大学博尔德分校分子细胞发育生物系,博士后研究助理;

20039-20091月,中国科学院长春应用化学研究所化学生物学实验室,获博士学位;

19999-20036月,东北师范大学,获学士学位。

 

研究领域

 

糖稳态维持的调控机制;

神经递质分泌和神经退行性疾病的分子机理;

细胞内膜接触位点和细胞间通讯的功能研究。

 

承担的科研项目

 

先后主持国家自然科学基金青年基金、面上项目、重大研究计划培育项目,NIH R03项目,江苏省特聘教授项目,江苏省杰出青年基金和省六大人才高峰高层次人才项目。

 

 

代表性论文

 

    1. Tiantian Qian, Chenlu Li, Ruyue He, Chun Wan, Yinghui Liu*, Haijia Yu*, Calcium-dependent and -independent lipid transfer mediated by tricalbins in yeast, J. Biol. Chem., 2021, in press.
    2. Chenlu Li, Tiantian Qian, Ruyue He, Chun Wan, Yinghui Liu*, Haijia Yu*, Endoplasmic Reticulum–Plasma Membrane Contact Sites: Regulators, Mechanisms, and Physiological Functions, Front. Cell Dev. Biol., 2021, 9, 627700.
    3. Yinghui Liu#, Chun Wan#, Shailendra S. Rathore, Michael H. B. Stowell, Haijia Yu*, Jingshi Shen*, SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting, Cell Rep., 2021, 34, 108611.
    4. Shifeng Wang, Yinghui Liu, Lauren Crisman, Chun Wan, Jessica Miller, Haijia Yu*, Jingshi Shen*, Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis, Traffic, 2020, 21, 636-646.
    5. Shailendra S. Rathore#, Yinghui Liu#, Haijia Yu*, Chun Wan, MyeongSeon Lee, Qian Yin, Michael H. B. Stowell, Jingshi Shen*, Intracellular vesicle fusion requires a membrane-destabilizing peptide located at the juxtamembrane region of the v-SNARE, Cell Rep., 2019, 29, 4583-4592.
    6. Daniel R. Gulbranson, Lauren Crisman, MyeongSeon Lee, Yan Ouyang, Bridget L. Menasche, Brittany A. Demmitt, Chun Wan, Toshifumi Nomura, Yihong Ye, Haijia Yu*, Jingshi Shen*, AAGAB controls AP2 adaptor assembly in clathrin-mediated endocytosis, Dev. Cell, 2019, 50, 436-446.
    7. Haijia Yu*, Lauren Crisman, Michael H. B. Stowell, and Jingshi Shen*, Functional reconstitution of intracellular vesicle fusion using purified SNAREs and Sec1/Munc18 (SM) proteins, Methods Mol. Biol. 2019, 1860, 237-249.
    8. Chong Shen#, Yinghui Liu#, Haijia Yu*, Daniel R. Gulbranson, Igor Kogut, Ganna Bilousova, Chen Zhang, Michael H. B. Stowell, Jingshi Shen*, The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis, J. Biol. Chem., 2018, 29318309-18317.
    9. Haijia Yu, Chong Shen, Yinghui Liu, Bridget L. Menasche, Yan Ouyang, Michael H. B. Stowell, and Jingshi Shen*SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteinsProc. Natl. Acad. Sci. U S A, 2018, 115, E8421-8429.
    10. Daniel R. Gulbranson, Eric M. Davis, Brittany A. Demmitt, Yan Ouyang, Yihong Ye, Haijia Yu*, Jingshi Shen* RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc. Natl. Acad. Sci. U S A, 2017, 114, E8224-E8233.
    11. Haijia Yu, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore,and Jingshi Shen*Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sitesProc. Natl. Acad. Sci. U S A, 2016, 113, 4362-4367.
    12. Haijia Yu#, Shailendra S. Rathore#, Chong Shen, Yinghui Liu, Yan Ouyang, Michael H. Stowell, Jingshi Shen*, Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding, J. Am. Chem. Soc., 2015, 137, 12873-12883.
    13. Chong Shen#, Shailendra S. Rathore#, Haijia Yu#, Daniel R. Gulbranson, Rui Hua, Chen Zhang, Nathan E. Schoppa, and Jingshi Shen*The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis, Nat. Commun., 2015, 6, 8852.
    14. Haijia Yu, Shailendra S. Rathore, Daniel R. Gulbranson, Jingshi Shen*, The N- and C-terminal domains of tomosyn play distinct roles in SNARE binding and fusion regulation, J. Biol. Chem., 2014, 289, 25571-25580.
    15. Haijia Yu, Shailendra S. Rathore, Jamie A. Lopez, Eric M. Davis, David E. James, Jennifer L. Martin, Jingshi Shen*,Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins, Proc. Natl. Acad. Sci. U S A, 2013, 110, E3271-3280.
    16. Haijia Yu, Shailendra S. Rathore, Eric M Davis, Yan Ouyang, Jingshi Shen*, Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner, Mol. Biol. Cell., 2013, 24, 1176-1184.
    17. Haijia Yu, Shailendra S. Rathore, Jingshi Shen*, Synip Arrests Soluble N- Ethylmale imide-sensitive Factor Attachment Protein Receptor (SNARE)-dependent Membrane Fusion as a Selective Target Membrane SNARE-binding InhibitorJ. Biol. Chem., 2013, 28818885-18893.
    18. Haijia Yu, Meng Li, Gongping Liu, Jie Geng, Jianzhi Wang, Jinsong Ren, Chuanqi Zhao, Xiaogang Qu*, Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide, Chem. Sci., 2012, 3, 3145-3153.
    19. Haijia Yu, Chuanqi Zhao, Yong Chen, Manliang Fu, Jinsong Ren, Xiaogang Qu*, DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity, J. Med. Chem., 2010, 53, 492–498.
    20. Haijia Yu, Xiaohui Wang, Manliang Fu, Jinsong Ren, Xiaogang Qu*, Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res., 2008, 36, 5695-5703.

 

联系方式

 

邮件:yuhaijia@njnu.edu.cn

通讯地址:江苏省南京市文苑路1号,南京师范大学生命科学学院,邮编:210023