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许凯

许凯

邮件:xukai@njnu.edu.cn
通讯地址:江苏省南京市文苑路1号,南京师范大学生命科学院,邮编:210023。

博士,南京师范大学生命科学学院微生物与生物技术研究所。主要从事植物病毒学研究,相关研究成果发表在PLoS Biology, PNAS, PLoS Pathogens, Journal of Virology, Current Opinion in Virology等杂志上,主要研究兴趣集中在脂类分子及脂类运输途径参与植物正义RNA病毒复制的过程和机制。脂类分子是真核细胞内重要的生物大分子,参与组成细胞器并参与细胞内许多重要的代谢途径。脂类分子也是正义RNA病毒复制所必须的关键寄主因子。本实验室通过对脂类分子合成和运输途径中关键基因进行分析,及在试管中建立体外的脂类分子研究体系,揭示脂类分子参与植物病毒复制的机理,以找到可以控制病毒复制的靶标途径。
实验室充分利用分子生物学、生物化学、细胞生物学、遗传学、蛋白组和脂质组的技术手段,通过对植物病毒在细胞内的致病机制及植物细胞的抗病机理的研究,对实验室成员进行相关科学知识和实验能力的全面培养、训练。本实验室欢迎具有生命科学相关学科背景的本科生、研究生和博士加入,进行本科毕业设计、研究生学习或博士后工作。

教育背景与工作经历:
2017.3 至今 南京师范大学生命科学学院;
2014.7 – 2016.9 美国肯塔基大学植物病理系博士后研究员;
2007.8 – 2014.6 美国肯塔基大学植物病理系博士研究助理,获博士学位;
2005.7 – 2007.3 中国农业大学农业生物技术国家重点实验室科研助理;
2001.9 – 2005.6 中国农业大学生物学院生物科学专业本科学习,获理学学士学位。

论文著作:
1. Xu K, Nagy PD.2017, Sterol-binding by the tombusviral replication proteins is essential for replication in yeast and plants. Journal of Virology 91 (7), e01984-16.
2. Xu K, Nagy PD.2016, Enrichment of phosphatidylethanolamine in viral replication organelles via co-opting the Rab5 endosomes by a positive-strand RNA virus. PLoS Biology 14(10): e2000128.
3. Nawaz-Ul-Rehman MS#, Prasanth KR#, Xu K#(#:共同一作), Sasvari Z#, Kovalev N, de Castro Martin IF, Barajas D, Risco C, Nagy PD. 2016, Viral replication protein inhibits cellular cofilin actin depolymerization factor to regulate the actin network and promote viral replicase assembly. PLoS Pathogens,12(2):e1005440.
4. Xu K, Nagy PD. 2015, RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes. Proceedings of the National Academy of Sciences USA, 112(14): E1782-E1791.
5. Xu K, Nagy PD. 2014, Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication. Current Opinion in Virology, 9: 119-126.
6. Xu K, Lin JY, Nagy PD. 2014, The Hop-like stress induced protein 1 co-chaperone is a novel cell-intrinsic restriction factor for mitochondrial tombusvirus replication. Journal of Virology, 88(16):9361-9378.
7. Xu K, Huang TS, Nagy PD. 2012, Authentic in vitro replication of two tombusviruses in isolated mitochondrial and endoplasmic reticulum membranes. Journal of Virology, 86(23):12779-12794.
8. Xu K, Nagy PD. 2010, Dissecting virus-plant interactions through proteomics approaches. Current Proteomics, 7(4): 316-327.
9. Xu K, Yoshida R. 2010, Statistical analysis on detecting recombination sites in DNA-β satellites associated with old world geminiviruses. Frontiers in Psychiatry, 1: 138. b
10. Nagy PD, Pogany J, Xu K. 2016. Cell-free and cell-based approaches to explore the roles of host membranes and lipids in the formation of viral replication compartment induced by Tombusviruses. Viruses, 8(3):68
11. Barajas D, Xu K, Sharma M, Wu CY, Nagy PD. 2014, Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology, 471:72-80.
12. Barajas D, Xu K, de Castro Martín IF, Sasvari Z, Brandizzi F, Risco C, Nagy PD. 2014, Co-opted oxysterol-binding ORP and VAP proteins channel sterols to RNA virus replication sites via membrane contact sites. PLoS Pathogens, 10(10):e1004388.
13. Shah Nawaz-ul-Rehman M, Martinez-Ochoa N, Pascal H, Sasvari Z, Herbst C,Xu K, Baker J, Sharma M, Herbst A, Nagy PD. 2012, Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C. Journal of Virology, 86(17): 9384-9395.
14. Pathak KB, Pogany J,Xu K, White KA, Nagy PD. 2012, Defining the roles of cis-acting RNA elements in tombusvirusreplicase assembly in vitro. Journal of Virology, 86(1):156-171.
15. Li Z, Pogany J, Panavas T, Xu K, Esposito AM, Kinzy TG, Nagy PD. 2009, Translation elongation factor 1A is a component of the tombusvirusreplicase complex and affects the stability of the p33 replication co-factor. Virology, 385(1):245-260.
16. Niu S, Wang B, Guo X, Yu J, Wang X, Xu K, Zhai Y, Wang J, Liu Z., 2009, Identification of two RNA silencing suppressors from banana bunchy top virus. Archives in Virology, 154(11):1775-1783.
17. 陈舒舒,许凯,徐彦军,潘灿平. 2006, 蜂蜜中氯霉素残留的检测及净化方法研究. 安全与环境学报. 6(2): 92-95.

学术会员
美国病毒学协会会员 (2010至今)