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夏欣一*

夏欣一,教授、主任医师、博士生导师

现任东部战区总医院检验科副主任、全军检验研究所所长助理。2020年2-4月,任武汉火神山医院检验科主任。南京大学医学院博士毕业,博士后。入选香江学者计划、江苏省“333工程”、省医学重点人才、军区“334”高层次科技人才。兼任省妇幼健康研究会检验分会副主委、省医师协会检验分会委员等。主持国家自然科学基金、省自然科学基金、省重点研发计划等课题10余项;以第一/通讯作者发表论文40余篇主要发表于BloodAnn Rheum DisNat CommunMol TherBrief BioinformClin Transl MedComput Struct Biotechnol JBioinformaticsCRISPR JInt J Cancer等权威期刊,入选ESI高被引论2篇;获中国妇幼健康科技成果一等奖、军队医疗成果二等奖等成果6项。

我院为南京大学附属医院,本学科是国家重点临床专科、江苏省和军队重点学科,实验室拥有充足的科研经费和良好的研究条件,欢迎有志青年加入本课题组,攻读硕、博士学位或从事博士后研究工作。联系方式:江苏省南京市中山东路305号,邮编:210002,Email: xinyixia@nju.edu.cn

 

主要研究方向

1)新型生物标志物及其作用机制

2)分子诊断新技术研发与应用

3)生殖遗传学研究

 

代表性论文(#, co-first author; *, corresponding author):

  1. Xia X#, Li K#, Wu L#, Wang Z#, Zhu M, Huang B, Li J, Wang Z, Wu W, Wu M, Li W, Li L, Cai Y, Bosco B, Zhong A, Liu X, Lv T, Gan Z, Chen G, Pan Y, Liu C, Zhang K, Xu X*, Wang C*, Wang Q*. Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion. Blood, 2020, 136(6):755-759.

Commentary by Tobian AAR & Shaz BH. Earlier the better: convalescent plasma. Blood. 2020, 136(6):652-654.

  1. Qin S#, Xu W#, Wang C#, Jiang S, Dai W, Yang Y, Shen J, Jin P*, Ma F*, Xia X*. Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteins. Brief Bioinform, 2021, doi: 10.1093/bib/bbab118
  2. Li K#, Huang B#, Wu M#, Zhong A#, Li L, Cai Y, Wang Z, Wu L, Zhu M, Li J, Wang Z, Wu W, Li W, Bosco B, Gan Z, Qiao Q, Wu J, Wang Q*, Wang S*, Xia X*. Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19. Nat Commun, 2020, 11(1):6044.
  3. Chen X#, Xu M#, Xu X, Zeng K, Liu X, Sun L, Pan B, He B, Pan Y, Sun H, Xia X*, Wang S*. METTL14 suppresses CRC progression via regulating N6-methyladenosine-dependent primary miR-375 processing. Mol Ther. 2020, 28 (2):599-612. (ESI Highly Cited Papers)
  4. Ye M, Fu D, Ren Y, Wang F, Wang D, Zhang F, Xia X*, Lv T*. Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. J Med Virol. 2020, 92(10): 1890-1901. (ESI Highly Cited Papers)
  5. Qin S#, Li W#, Shi X#, Wu Y#, Wang C, Shen J, Pang R, He B, Zhao J, Qiao Q, Luo T, Guo Y, Yang Y, Han Y, Wu Q, Wu J, Dai W, Zhang L, Chen L, Xue C, Jin P*, Gan Z*, Ma F*, Xia X*. 3044 cases reveal important prognosis signatures of COVID-19 patients. Comput Struct Biotechnol J. 2021, 19(1):1163-1175.
  6. Wu J#, Shen J#, Han Y#, Qiao Q#, Dai W, He B, Pang R, Zhao J, Luo T, Guo Y, Yang Y, Wu Q, Jiang W, Zhang J, Zhang M, Li N, Li W, Xia X*.Upregulated IL-6 induces worse COVID-19 prognosis, calling for Tocilizumab and convalescent plasma treatment. Front Immunol, 2021, 12, 598799.
  7. Shen J#, Wu J#, Yang Y#, Wang P, Luo T, Guo Y, Zhao J, Dai W, Han Y, Zhu P, Wu Q, Li W, Chen A, Xue C*, Xia X*. The paradoxical problem with COVID-19 ocular infection: Moderate clinical manifestation and potential infection risk. Comput Struct Biotechnol J. 2021, 19:1063-1071.
  8. Shao J#, Liang Y#, Li Y#, Ding R#, Zhu M, You W, Wang Z, Huang B, Wu M, Zhang T, Li K, Wu W, Wu L, Wang Q*, Xia X*, Wang S*, Lu L*. Implications of liver injury in risk-stratification and management of patients with COVID-19. Hepatol Int. 2021, 15(1): 202-212.
  9. Lin J#, Dai W#, Li W#, Xiao L#, Luo T, Guo Y,  Yang Y, Han Y, Zhu  P,  Wu Q,  He B, Wu J*, Xia X*. Potential false-positive and false-negative IgG/IgM antibody results of COVID-19 with heat-inactivation. Front Med, 2021, 7: 589080.
  10. Dai W#, Wu J#, Li T#, Shen J, Pang R, Luo T, Guo Y, Yang Y, Zhao J, Zhang M, Li N, Han Y, Wu Q, Li W, Xia X*. Clinical outcomes for COVID-19 patients with diabetes mellitus treated with convalescent plasma transfusion in Wuhan, China. J Med Virol. 2021, 93(4): 2321-2331.
  11. Zhao J#, Pang R#, Wu J#, Guo Y, Yang Y, Zhang L, Xia X*. Clinical characteristics and outcomes of patients with COVID-19 and rheumatic disease in China 'hot pot' versus in US 'hot pot': similarity and difference. Ann Rheum Dis. 2021. doi: 10.1136/annrheumdis-2020-218183.
  12. Jiang W#, Li W#, Xiong L#, Wu Q#, Wu J, He B,Shen J, Pang R, Luo T, Guo Y, Yang Y, Han Y, Dai W, Zhu P , Xia X*. Clinical efficacy of convalescent plasma therapy on treating COVID‐19 patients: Evidence from matched study and a meta-analysis. Clin Transl Med, 2020, 10(8): e259.
  13. Qin S#, Xia X#, Shi X, Ji X*, Ma F*, Chen L*. Mechanistic insights into SARS-CoV-2 epidemic via revealing the features of SARS-CoV-2 coding proteins and host responses upon its infection. Bioinformatics, 2020, 36(21), 5133–5138.
  14. Liu S, Wu J, Xia Q, Liu H, Li W, Xia X*, Wang J*. Finding new cancer epigenetic and genetic biomarkers from cell-free DNA by combining SALP-seq and machine learning. Comput Struct Biotechnol J. 2020, 18, 1891-1903.
  15. Xu X, Luo T, Gao J, Lin N, Li W, Xia X*, Wang J*. CRISPR-Assisted DNA Detection: A Novel dCas9-Based DNA Detection Technique. CRISPR J. 2020 , 3(6):487-502.
  16. He B#, Zhong A#, Wu Q#, Liu X#, Lin J, Chen C, He Y, Guo Y, Zhang M, Zhu P, Wu J, Wang C*, Wang S*, Xia X*. Tumor biomarkers predict clinical outcome of COVID-19 patients. J Infect. 2020, 81(3):464-466.
  17. Yang R#, Duan Y#, Kong Q, Li W, Xu J, Xia X*, Sang H*. What do we learn from dystrophic epidermolysis bullosa, nails only? Idiopathic nail dystrophy may harbor a COL7A1 mutation as the underlying cause. J Dermatol. 2020, 47(7):782-786.
  18. Zhang LB#, Pang RR#, Qiao QH#, Wang ZH#, Xia XY*, Wang CJ*, Xu XL*. Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma. Mil Med Res. 2020, 7(1):45.
  19. Wu J, Dai W, Wu L, Li W, Xia X*, Wang J*. Decoding genetic and epigenetic information embedded in cell free DNA with adapted SALP-seq. Int J Cancer. 2019, 145(9):2395-2406.
  20. Zhang B, Xia Q, Wang Q, Xia X*, Wang J*. Detecting and typing target DNA with a novel CRISPR-typing PCR (ctPCR) technique. Anal Biochem. 2018, (561-562), 37-46.
  21. Zhang B, Wang Q, Xu X, Xia Q, Long F, Li W, Shui Y, Xia X*, Wang J*. Detection of target DNA with a novel Cas9/sgRNAs-associated reverse PCR (CARP) technique. Anal Bioanal Chem, 2018, 410(12), 2889-2900.
  22. Zhu P, Li W, Ni M, Zhang C, Liu S, Wu Q, Jiang W, Zhang J, Zhang M, Li X, Cui Y, Xue C, Xia X*. The P20R mutation of αB-crystallin diminishes its anti-apoptotic activity in human lens epithelial cells. Biochem Biophys Res Commun. 2017, 483(1):463-467.
  23. Wu Q, Zhang J, Zhu P, Jiang W, Liu S, Ni M, Zhang M, Li W, Zhou Q, Cui Y, Xia X*. The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis. BMC Med Genet. 2017, 18(1):81.
  24. Jiang W #, Xiong L #, Yang B, Li W, Zhang J, Zhou Q, Wu Q, Li T, Zhang C, Zhang M, Xia X*. Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity. Sci Rep. 2016, 6:26647.
  25. Yang R, Hu Z, Kong Q, Li W, Zhang L, Du X, Huang S, Xia X*, Sang H*. A known mutation in GJB6 in a large Chinese family with hidrotic ectodermal dysplasia. J Eur Acad Dermatol Venereol. 2016, 30(8):1362-1365.
  26. Xia XY#, Wang WP#, Li TF#, Li WW#, Wu QY, Li N, Zhang C, Gao HL, Li XJ, Cui YX*. A parthenogenetic maternal and double paternal contribution to an ovotesticular disorder of sex development. Mol Cytogenet. 2014, 28;7(1):16. 
  27. Xia XY#, Li N#, Cao X, Wu QY, Li TF, Zhang C, Li WW, Cui YX, Li XJ*, Xue CY*. A novel COL4A1gene mutation results in autosomal dominant non-syndromic congenital cataract in a Chinese family. BMC Med Genet, 2014,15(1):97.
  28. Li N#, Yu J#, Cao X, Wu QY, Li WW, Li TF, Zhang C, Cui YX, Li XJ, Yin ZM, Xia XY*. A novel p. Gly630Ser mutation of COL2A1 in a Chinese family with presentations of Legg-Calvé-Perthes disease or avascular necrosis of the femoral head. PLoS One. 2014, 9(6):e100505.
  29. Wu QY#, Li WW#, Li N, Li TF, Zhang C, Ni T, Cui YX, Li XJ, Xia XY*. A novel nonsense mutation of ADAR1 gene in a Chinese patient with dyschromatosis symmetrica hereditaria. J Eur Acad Dermatol Venereol. 2014, 28(12):1832-1833.
  30. 中国研究型医院学会检验医学专业委员会. 临床实验室应对突发公共卫生事件体系与能力建设专家共识. 中华检验医学杂志,2021,441):12-24. (专家组成员)
  31. 中华医学会男科学分会. 男性生殖遗传学检查专家共识. 中华男科学学杂志,2015, 2112):1138-1142.(主要执笔者)