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王斌*

研究员、教授、硕士生导师、南京鼓楼医院研发转化平台管理处副处长(主持工作)、临床干细胞研究室主任

通讯地址:江苏省南京市玄武区中山路358号科教楼801室,邮编:210000

E-mail: wangbin022800@126.com

 

 

 

 

 

基本情况

2003年毕业于武汉华中科技大学同济医学院,获毒理学专业硕士学位,2008年毕业于  中国科学院遗传与发育生物学研究所,获发育生物学博士学位。毕业后赴美国康奈尔大学医学院和美国杜克大学从事博士后研究,从事发育及神经再生研究。2014年入职中国科学院遗传与发育生物学研究所,受聘副研究员。2016年入职南京鼓楼医院,现任医院研发转化平台管理处副处长(主持工作)、临床干细胞研究室主任,主要从事治疗性临床干细胞库的建设及临床干细胞转化研究:建立了完备的临床级干细胞制备中心,成功制备多种临床级脐带间、脐带血、胎盘、骨髓、脂肪间充质干细,已经建立起初具规模的干细胞公益库和自体干细胞库。南京鼓楼医院为全国首批30家干细胞临床备案机构,我们实验室与多个临床科室合作开展临床治疗性试验项目,如子宫内膜瘢痕化修复、女性卵巢早衰、骨关节炎、糖尿病等,已经取得众多成果,一些细胞产品已经开始项目转化。

人才称号

江苏省第十三批“六大人才高峰”项目(2016)

南京市“十三五”青年人才(第一层次)(2016)

江苏省“双创”人才(卫生类创新)(2019)

荣誉或奖励

中国细胞生物学会干细胞第六届年会干细胞社会公益奖(2016)

中国细胞生物学会干细胞第七届年会干细胞科普奖(2017)

中国研究型医院学会神经再生与修复专业委员会干细胞产业转化学组第二届年会 “干细胞研究创新奖”(2019)

南京市医学新技术特等奖:临床级间充质干细胞质量体系建立及重度宫腔粘连的临床治疗,(排名第一)(2021)

 

学术兼职

江苏省发育与细胞生物学会理事、中国老年学和老年医学学会老年病学分化干细胞与再生医学专家委员会常务委员、中国研究型医院学会神经再生与修复专业委员会干细胞产业转化学组组长

主要研究方向

1)临床级细胞制备及优效再生种子细胞的筛选研究

2)细胞质量检验方法研究

3)纤维化、神经损伤等多种难治性疾病的干细胞临床应用研究

承担的主要课题

12020-2023国家自然科学基金面上项目(项目号:82070459,55万)

2 2020年-2022 江苏省社会发展项目 (项目号BE2020765,100万)

3 2020-2023年南京市医学重点科技发展项目(项目号ZKX20016,10万)

4 2016-2019国家自然科学基金面上项目(项目号81571213,67.5万)

5 2019-2022年江苏省高层次创新创业(“双创”计划)卫生类创新人才(50万)。

6江苏省第十三批“六大人才高峰”项目(WSN-155)。

7主持南京市“十三五”规划重点项目ZDX16005 50

8南京市“十三五”青年人才项目(第一层次QRX17006:16万

9参与科技部2017年重大研发计划干细胞专项,2017YFA0104300,负责标记后临床干细胞的质量控制体系标准建设及大动物脊髓损伤干细胞后干细胞移植后示踪。(经费230万)

102018南京科技创新留学人员择优资助项目应用类(10万)

11其它多项横向课题。

 

主要专利及成果转化

1.  应用于间充质干细胞软骨诱导分化的耗材;

专利号:201821355820.2,该专利已经转化。

2.  一种干细胞输液袋;

专利号:ZL 202020321336.9

3.  一种肝脏原位移植干细胞来源的外泌体装置;

专利号:ZL 202020808805.X

代表性论文

1.Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, YuanyuanXie, Chenxun Tai, Shuo Liu, Yi Cui, Bin Wang*(王斌). Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway. Stem Cell Research & Therapy(2021) 21;12(1):468.

2. YuanyuanXie, Shuo Liu, Liudi Wang, Hui Yang, Chenxu Tai, Li Ling, Libo Chen, Shanshan Liu, Bin Wang*(王斌). Individual heterogeneity screened umbilical cord-derived mesenchymal stromal cells with high Treg promotion demonstrate improved recovery of mouse liver fibrosis. Stem Cell Research & Therapy (2021) 12:359.

3.Shuo Liu, Yuan-Yuan Xie, Liu-Di Wang, Chen-Xu Tai, Dong Chen, Dan Mu,Yan-Yan Cui, Bin Wang*(王斌).A multi-channel collagen scaffold loaded with neuralstem cells for the repair of spinal cord injury. NEURAL REGENERATION RESEARCH(2021) 16:11.

4.    Chenxu Tai Liudi Wang YuanyuanXieTianyun Gao Feifei Huang, Bin Wang*(王斌). Analysis of Key Distinct Biological Characteristicsof Human Placenta-Derived MesenchymalStromal Cells and Individual HeterogeneityAttributing to Donors.Cells Tissues Organs(2021)210(1):45-57.

5     Yu Li, Ping-Ping Shen*,Bin Wang*(王斌). Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy.NEURAL REGENERATION RESEARCH(2021)16(8):1500-1509.

6.     Tian-Yun Gao,Fei-Fei Huang, Yuan-Yuan Xie, Wen-Qing Wang, Liu-Di Wang, Dan Mu, Yi Cui,Bin Wang*(王斌). Dynamic changes in the systemic immune responses of spinal cord injury model mice. NEURAL REGENERATION RESEARCH(2021) 16(2):382-387.

7.    YuanyuanXie, Wei Liu , Shuo Liu , Liudi Wang, Dan Mu, Yi Cui, Yanyan Cui and Bin Wang*(王斌). The quality evaluation systemestablishment of mesenchymal stromalcells for cell-based therapy products. Stem Cell Research & Therapy(2020) 11:176.

8.    YuanyuanXie, Wei Liu, Bing Zhang, Bin Wang* (王斌), Liudi Wang, Shuo Liu, Bo Chen, Xiaoli Mai, FengchaoZang. Systematic Intracellular Biocompatibility Assessments of Superparamagnetic Iron Oxide Nanoparticles in Human Umbilical Cord Mesenchyme Stem Cells in Testifying Its Reusability for Inner Cell Tracking by MRI.Journal ofBiomedical Nanotechnology. (2019)(15)2179–2192.

9.    Li Y,Wang B*(王斌),Gu N*. Regulations on cell therapy products in China: a brief history and current status.Regen Med(2019)14(8):791-803.

10.    Anyuan Shi, AeraliHeinayati, DongyuBao, Huifen Liu, Xiaochen Ding, Xin Tong, Liudi Wang, Bin Wang*(王斌), Haiyan Qin*. Small molecule inhibitor of TGF-β signalingenables robust osteogenesis of autologousGMSCs to successfully repair minipig severemaxillofacial bone defects. Stem Cell Research & Therapy (2019) 13;10(1):172.

11.    Shuo LiuYuan-Yuan XieBin Wang*(王斌). Role and prospects of regenerative biomaterials in the repair of spinal cord injury. Neural Regeneration Research. (2019);14(8):1352-1363.

12.    Wei Liu, YuanyuanXie,Tianyun Gao, Feifei Huang, Liudi Wang, Lijun Ding, Wenqing Wang, Shuo Liu, Jianwu Dai and Bin Wang*(王斌). Reflection and observation: cell-basedscreening failing to detect HBV in HUMSCsderived from HBV-infected mothersunderscores the importance of morestringent donor eligibility to reduce risk oftransmission of infectious diseases for stemcell-based medical products. Stem Cell Research & Therapy(2018) 9:177.

13.Han S, Wang B*(王斌), Li X,Xiao Z, Han J, Zhao Y, Fang Y, Yin Y, Chen B, Dai J.Bone marrow-derived mesenchymal stem cells in three-dimensional culture promote neuronal regeneration by neurotrophic protection and immunomodulation. J Biomed Mater Res A (2016)104(7):1759-69.

14.    Wang, B(王斌), Rao, Y-H, Inoue, M.,Hao, R., Qiu, W., Shinohara, M., and Yao, T.-P.,Microtubule acetylation amplifies p38 kinase signaling and anti-inflammatory IL-10 production.Nature Communications(2014)17(5):3479.

15.    Han S*, Wang B*(王斌), Jin W, Xiao Z, KapurWood M, Chen B, Ding W, Li X, Yuan B, Zhu T, Wang H, Wang J, Dong Q, Liang W & Dai J-W. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials(2015)41:89-96.