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副教授,博士,硕士研究生导师,1996-2000年南京师范大学就读本科;20007月至今,留校工作;2002-2005年在职攻读硕士学位;2007-2010年在职攻读博士学位。20096月台湾国立卫生研究院访问学习;2014-2015年到美国俄克拉荷马大学访问学者;20167月芬兰赫尔辛基大学访问学者。目前是中国细胞生物学学会会员, 江苏省生化学会会员,江苏省发育生物学会会员。


1. 碱基切除修复对肿瘤发生发展的作用机制研究;

2. 肿瘤基因治疗与免疫治疗的分子基础研究;

3. 肿瘤细胞抗药性的分子机理研究。


  1. GAPDH 在肿瘤细胞抗药性中的作用机制研究(18KJA180006),江苏省高等学校自然科学重大项目,在研,主持;
  2. Egr-1通过调控PRL-3转录与翻译后修饰促进肝癌细胞离散(30800574),国家自然科学基金青年基金项目,结题,主持;
  3. HGF/Egr-1/PRL-3/Ezrin/E-cadherin 信号通路影响HepG2细胞离散(BK2008432),江苏省自然科学基金,结题,主持;
  4. 活体、动态观察小分子化合物对信号通路转导作用的细胞模型的建立(07KJD180103),江苏省高校自然科学基金,结题,主持。


  1. Wang W#, Ma Y#, Huang M, Liang W, Zhao X, Li Q, Wang S, Hu Z, He L, Gao T, Chen J, Pan F*, Guo Z*. Asymmetrical arginine dimethylation of histone H4 by 8-oxoG/OGG1/PRMT1 is essential for oxidative stress induced transcription activation. Free Radical Biology & Medicine, 2021, 164:175-186.
  2. Wu T#, Zhu H#, Zhang M, Sun Y, Yang Y, Gu L, Zhang J, Mu D, Wu C, Hu Z, Jiang L, Jia S, Zhang Y, He L*, Pan F*, Guo Z*. FEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway. Gene Therapy, 2021.
  3. Ma Z#, Wang W#, Wang S, Zhao X, Ma Y, Wu C, Hu Z, He L, Pan F*, Guo Z*. Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress. Redox Biology, 2020, 37:101653.
  4. He L#, Hu Z#, Sun Y#, Zhang M, Zhu H, Jiang L, Zhang Q, Mu D, Zhang J, Gu L, Yang Y, Pan F*, Jia S*, Guo Z*. PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells. DNA Repair, 2020, 95:102953.
  5. Ci S#, Xia W#, Liang W, Qin L, Zhang Y, Dianov GL, Wang M, Zhao X, Wu C, Alagamuthu KK, Hu Z, He L, Pan F*, Guo Z*. Src-mediated phosphorylation of GAPDH regulates its nuclear localization and cellular response to DNA damage. FASEB J, 2020, 34:10443-10461.
  6. Wang M, Long K, Li E, Li L, Li B, Ci S, He L, Pan F, Hu Z*, Guo Z*. DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation. Oncogene, 2020, 39(33):5507-5519.
  7. Xia W#, Ci S#, Li M, Wang M, Dianov GL, Ma Z, Li L, Hua K, Alagamuthu KK, Qing L, Luo L, Edick AM, Liu L, Hu Z, He L, Pan F*, Guo Z*: Two-way crosstalk between BER and c-NHEJ repair pathway is mediated by Pol b and Ku70. FASEB J, 2019, 33(11).
  8. Zhang M, Wang W, Zhou N*, Yuan P, Su Y, Shao M, Chi C, Pan F*: Near-infrared light triggered photo-therapy, in combination with chemotherapy using magnetofluorescent carbon quantum dots for effective cancer treating. Carbon, 2017,118:752-764.
  9. Sun H#, He L#, Wu H#, Pan F, Wu X, Zhao J, Hu Z, Sekhar C, Li H, Zheng L, Chen H*, Shen B*, Guo Z*: The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation. Oncogene, 2017, 36(2):194-207.
  10. Pan F#, Zhao J#, Zhou T#, Kuang Z, Dai H, Wu H, Sun H, Zhou X, Wu X, Hu Z, He L, Shen B, Guo Z*: Mutation of DNA Polymerase beta R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice. Scientific reports, 2016, 6:28614.
  11. Wang J#*, Pan F#, Soininen J, Heino J, Shen J, Nutrient enrichment modifies temperature-biodiversity relationships in large-scale field experiments. Nature Communications, 2016, 7:1396.