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陆玲

教授,博导/Professor

教育经历

1995/09-1998/12  南京农业大学微生物学专业,博士

1985/09-1988/07  南京农业大学植物生理与生物化学专业,硕士

1981/09-1985/07  南京农业大学农学系,学士

科研工作经历

2009/09-至今    南京师范大学生命科学学院,教授

2007/09-2009/08  美国加州大学医学院基因中心,访问教授

2005/08-2007/08  南京师范大学生命科学学院,教授

2002/04-2005/08  美国加州大学戴维斯分校生物学部,博士后

1988/08-2002/04  南京师范大学生物系任助教、讲师、副教授                                          

主要科研领域与方向

丝状真菌功能基因调控机理; 丝状真菌曲霉生长和形态发育调控机制; 微生物资源开发利用

主要学术任职和学术成绩

目前担任江苏省微生物与功能基因组学重点实验室主任、国家自然科学基金医学部和生命科学部重点项目会评专家、中国菌物学会理事、国际丝状真菌专业杂志 (FG&B, FBBJM) 编辑部成员。20162019年连续被选举为国际曲霉委员会。申请人近年来分别在国际知名杂志发表系列论文40多篇, h-Index:2120193月)。相关论文获得 Faculty of 1000同行评议以及学科热点论文和高被引论文。近年来曾作为特邀报告者分别在“The 8th Advances Against Aspergillosis conference, Lisbon, Portugal, 2018”,“The Thirteenth International Aspergillus Meeting, Paris, 2016”等多次作学术报告,研究成果受到了与会者和国内外的关注。

主持的在研项目

  1. 烟曲霉Cys(6)Zn(2)型转录因子LeuB家族调控亮氨酸合成网络和毒力的解析,国家自然科学基金面上项目, 31770086, 2018-2021。
  2. 钙信号与光感知途径在曲霉逆境响应和极性生长中的信号交流,国家自然科学基金委员会与德国科学基金会合作研究项目资助,3181101271,2019-2021。
  3. 微生物功能基因的挖掘和资源利用,江苏省高校优秀科技创新团队项目,17CXTD00014,2018-2020

近期发表主要论文:

  1. Li X.D., Li Y.K., Wang R., Wang Q.Z., Lu L., Toxoflavin produced by Burkholderia gladioli from Lycoris aurea is a new broad-spectrum fungicide. Appl. Environ. Microbiol. 2019, 85:e00106-19.
  2. Cai Z.D., Du W.L., Liu L., Pan D.D., Lu L., Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation. mSphere 2019, 4(1): p. e00670-18.
  3. Long N.B., Orasch T., Zhang S.Z., Gao L., Xu X.L., Hortschansky P., Ye J., Zhang F.L., Xu K., Gsaller F., Strassburger, M., Binder, U., Heinekamp, T., Brakhage, A. A., Haas, H., Lu, L., The Zn(2)Cys(6)-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. Plos Genet 2018, 14(10) : p. e1007762-84.
  4. Song J.X., Zhang S.Z., Lu L., Fungal cytochrome P450 protein Cyp51: What we can learn from its evolution, regulons and Cyp51-based azole resistance. Fungal Biol Rev 2018, 32(3): p. 131-142.
  5. Cai Z.D., Du W.L., Zhang Z., Guan L.Y., Zeng Q.Q., Chai Y.F., Dai C.C., Lu L., The Aspergillus fumigatus transcription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA. Cell Microbiol 2018, 20(10): p. e12864-78.
  6. Wei H., Yue S., Zhang S.Z., Lu L., Lipid-Lowering Effect of the Pleurotus eryngii (King Oyster Mushroom) Polysaccharide from Solid-State Fermentation on Both Macrophage-Derived Foam Cells and Zebrafish Models. Polymers 2018, 10(5): p. 492-502.
  7. Zhang C., Meng X.H., Gu H.Y., Ma Z.H., Lu L., Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus. G3 2018, 8(7): p. 2291-2299.
  8. Takeshita N., Evangelinos M., Zhou L., Serizawa T., Somera-Fajardo R.A., Lu L., Takaya N., Nienhaus G.U., Fischer R., Pulses of Ca(2+) coordinate actin assembly and exocytosis for stepwise cell extension. Proc Natl Acad Sci U S A 2017, 114(22): p. 5701-5706.
  9. Wei, X., P. Chen, R. Gao, Y. Li, A. Zhang, F. Liu, and Lu L., Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance. Antimicrob Agents Chemother, 2017. 61(1): p. 1e02101-16
  10. Song, J., P. Zhai, and L. Lu, Damage resistance protein (Dap) contributes to azole resistance in a sterol-regulatory-element-binding protein SrbA-dependent way. Appl Microbiol Biotechnol, 2017. 101(9): p. 3729-3741.
  11. Long, N., X. Xu, Q. Zeng, H. Sang, and Lu L., Erg4A and Erg4B Are Required for Conidiation and Azole Resistance via Regulation of Ergosterol Biosynthesis in Aspergillus fumigatus. Appl Environ Microbiol, 2017. 83(4): p. e02924-16
  12. Jiang, P., W.F. Wei, G.W. Zhong, X.G. Zhou, W.R. Qiao, R. Fisher, and Lu L ., The function of the three phosphoribosyl pyrophosphate synthetase (Prs) genes in hyphal growth and conidiation in Aspergillus nidulans. Microbiology, 2017. 163(2): p. 218-232.
  13. Zhang, Y., Q. Zheng, C. Sun, J. Song, L. Gao, S. Zhang, A. Munoz, N.D. Read, and Lu L., Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus. PLoS Genet, 2016. 12(4): p. e1005977-6006.
  14. Zhang, C., X. Meng, X. Wei, and Lu L., Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus. Fungal Genet Biol, 2016. 86: p. 47-57.
  15. Wang, S., X. Liu, H. Qian, S. Zhang, and Lu L., Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca2+ Homeostasis in Aspergillus nidulans. Appl Environ Microbiol, 2016. 82(11): p. 3420-30.
  16. Song, J., P. Zhai, Y. Zhang, C. Zhang, H. Sang, G. Han, N.P. Keller, and Lu L., The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. MBio, 2016. 7(1): p. e01919-15.
  17. Lu, L., P. Sirish, Z. Zhang, R.L. Woltz, N. Li, V. Timofeyev, A.A. Knowlton, X.D. Zhang, E.N. Yamoah, and N. Chiamvimonvat, Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem, 2015. 290(8): p. 4663-76.

专利申请:

  1. 陆玲,雍阳阳,陈晶晶,一种构建泡沫细胞模型检测食用菌中降血脂有效成分的方法,公开号CN102559845A;
  2. 陆玲,雍阳阳,陈晶晶,邢美春,一种具有减少泡沫细胞脂质积累的杏鲍菇多糖及其制备方法,公开号CN102827305A
  3. 陆玲,岳尚,魏华,王亭立,一种sgRNA、重组质粒、敲除pyrG基因的细胞株的构建方法及其应用,公开号CN 109321548A