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陆玲

教育经历

1995/09-1998/12  南京农业大学微生物学专业,博士

1985/09-1988/07  南京农业大学植物生理与生物化学专业,硕士

1981/09-1985/07南京农业大学农学系,学士

科研工作经历

2009/09-至今南京师范大学生命科学学院,教授

2007/09-2009/08美国加州大学医学院基因中心,访问教授

2005/08-2007/08南京师范大学生命科学学院,教授

2002/04-2005/08  美国加州大学戴维斯分校生物学部,博士后

1988/08-2002/04南京师范大学生物系任助教、讲师、副教授

主要科研领域与方向

丝状真菌功能基因调控机理;丝状真菌曲霉生长和形态发育调控机制;微生物资源开发利用

主要学术任职和学术成绩

目前担任江苏省微生物与功能基因组学重点实验室主任、国家自然科学基金医学部和生命科学部重点项目会评专家、中国菌物学会理事、国际丝状真菌专业杂志 (FG&B, FBBJM) 编辑部成员;国际曲霉委员会委员。相关论文获得了Faculty of 1000同行评议以及学科热点论文和高被引论文。近年来曾作为特邀报告者分别在国内外大会中作学术报告,研究成果受到了国内外同行的关注。

主持的在研项目

  1. 烟曲霉Cys(6)Zn(2)型转录因子LeuB家族调控亮氨酸合成网络和毒力的解析,国家自然科学基金面上项目, 31770086, 2018-2021。
  2. 钙信号与光感知途径在曲霉逆境响应和极性生长中的信号交流,国家自然科学基金委员会与德国科学基金会合作研究项目资助,3181101271,2019-2021。
  3. 微生物功能基因的挖掘和资源利用,江苏省高校优秀科技创新团队项目,17CXTD00014,2018-2021
  4. 化学品合成非自然途径构建与组装,国家重点研发计划专项 ,2019YFA090049, 2020-2024

 

近期发表主要论文:

  1. Wenlong Du , Pengfei Zhai , Tingli Wang , Michael J Bromley , Yuanwei Zhang ,  Lu L*. The C 2 H 2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus.Antimicrob Agents Chemother.2021,01839-20.
  2. Zhang Y, Fan J, Ye J, Lu L. The fungal-specific histone acetyltransferase Rtt109 regulates development, DNA damage response, and virulence in Aspergillus fumigatus. Mol Microbiol. 2020 Dec 10. doi: 10.1111/mmi.14665. Epub ahead of print. PMID: 33300219.
  3. Zhang C, Ren Y, Gao L, Gu H, Lu L. Electron donor cytochrome b5 is required for hyphal tip accumulation of sterol-rich plasma membrane domains and membrane fluidity in Aspergillus fumigatus. Appl Environ Microbiol. 2020 Nov 30;87(4):e02571-20. doi: 10.1128/AEM.02571-20.
  4. Wang T, Yue S, Jin Y, Wei H, Lu L. Advances allowing feasible pyrG gene editing by a CRISPR-Cas9 system for the edible mushroom Pleurotus eryngii. Fungal Genet Biol. 2021 Feb;147:103509. doi: 10.1016/j.fgb.
  5. Yeqi Li; Yuanwei Zhang; Chi Zhang; Xiaolei Wei; Peiying Chen; *Lu L; Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance, Proc Natl Acad Sci U S A2020,117(3):1711-1721, 2019, 117(3)1711-1721.
  6. Xiaogang Zhou, Likun Zheng, Luyu Guan, Jing Ye, Aleksandra Virag, Steven D. Harris, *Ling Lu,The Scaffold Proteins Paxillin B and a-Actinin Regulate Septation in Aspergillus nidulans via Control of Actin Ring Contraction. Genetics, 2020,215.
  7. Yuan Chen, François Le Mauff, Yan Wang, Ruiyang Lu, Donald Sheppard, * Lu L, and *Shizhu Zhang, The transcription factor SomA synchronously regulates biofilm formation and cell wall homeostasis in Aspergillus fumigatus. mBio. 2020. 116e02329-20 .
  8. Zheng Zhang, Yuan Jiang, Jun Chen, Peiying Chen, Qingtao Kong, Lu L,* Hong Sang In vitro and in vivo characterization of two nonsporulating Aspergillus fumigatus clinical isolates from immunocompetent patients. Med Mycol 2020 58(4):543-551. doi: 10.1093/mmy/myz076.
  9. Li X.D., Li Y.K., Wang R., Wang Q.Z., Lu L., Toxoflavin produced by Burkholderia gladioli from Lycoris aurea is a new broad-spectrum fungicide.Appl. Environ. Microbiol.2019,85:e00106-19.
  10. Cai Z.D., Du W.L., Liu L., Pan D.D., Lu L.,Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation.mSphere2019, 4(1): p. e00670-18.
  11. Long N.B., Orasch T., Zhang S.Z., Gao L., Xu X.L., Hortschansky P., Ye J., Zhang F.L., Xu K., Gsaller F.,Strassburger, M., Binder, U., Heinekamp, T., Brakhage, A. A., Haas, H., Lu, L.,The Zn(2)Cys(6)-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus.Plos Genet2018, 14(10):p. e1007762-84.
  12. Song J.X., Zhang S.Z., Lu L., Fungal cytochrome P450 protein Cyp51: What we can learn from its evolution, regulons and Cyp51-based azole resistance. Fungal Biol Rev2018, 32(3):p. 131-142.
  13. Cai Z.D., Du W.L., Zhang Z., Guan L.Y., Zeng Q.Q., Chai Y.F., Dai C.C., Lu L.,The Aspergillus fumigatus transcription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA.Cell Microbiol2018, 20(10):p.e12864-78.
  14. Zhang, S.Chen, Y. Ma, Z. Chen, Q. Ostapska, H. Gravelat, F. N., #Lu, L., #Sheppard, D. C., PtaB, a lim-domain binding protein in Aspergillus fumigatus regulates biofilm formation and conidiation through distinct pathways. Cellular Microbiol, 2018, 20. e12799.
  15. Wei H., Yue S., Zhang S.Z., Lu L.,Lipid-Lowering Effect of the Pleurotus eryngii (King Oyster Mushroom) Polysaccharide from Solid-State Fermentation on Both Macrophage-Derived Foam Cells and Zebrafish Models.Polymers2018, 10(5):p. 492-502.
  16. Zhang C., Meng X.H., Gu H.Y., Ma Z.H.,Lu L.,Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus. G32018, 8(7):p. 2291-2299.
  17. Takeshita N., Evangelinos M., Zhou L., Serizawa T., Somera-Fajardo R.A., Lu L., Takaya N., Nienhaus G.U., Fischer R.,Pulses of Ca(2+) coordinate actin assembly and exocytosis for stepwise cell extension.Proc Natl Acad Sci U S A2017, 114(22):p. 5701-5706.
  18. Wei, X., P. Chen, R. Gao, Y. Li, A. Zhang, F. Liu, and Lu L., Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance. Antimicrob Agents Chemother, 2017. 61(1):p. 1e02101-16
  19. Song, J., P. Zhai, and L. Lu, Damage resistance protein (Dap) contributes to azole resistance in a sterol-regulatory-element-binding protein SrbA-dependent way.Appl Microbiol Biotechnol, 2017.101(9):p. 3729-3741.
  20. Long, N., X. Xu, Q. Zeng, H. Sang, and Lu L., Erg4A and Erg4B Are Required for Conidiation and Azole Resistance via Regulation of Ergosterol Biosynthesis in Aspergillus fumigatus.Appl Environ Microbiol, 2017. 83(4):p. e02924-16
  21. Jiang, P., W.F. Wei, G.W. Zhong, X.G. Zhou, W.R. Qiao, R. Fisher, and LuL., The function of the three phosphoribosyl pyrophosphate synthetase (Prs) genes in hyphal growth and conidiation in Aspergillus nidulans.Microbiology, 2017. 163(2): p. 218-232.
  22. Zhang, Y., Q. Zheng, C. Sun, J. Song, L. Gao, S. Zhang, A. Munoz, N.D. Read, and LuL., Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus.PLoS Genet, 2016. 12(4): p. e1005977-6006.
  23. Zhang, C., X. Meng, X. Wei, and LuL., Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus.Fungal Genet Biol, 2016. 86: p. 47-57.
  24. Wang, S., X. Liu, H. Qian, S. Zhang, and Lu L., Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca2+ Homeostasis in Aspergillus nidulans.Appl Environ Microbiol, 2016. 82(11): p. 3420-30.
  25. Song, J., P. Zhai, Y. Zhang, C. Zhang, H. Sang, G. Han, N.P. Keller, andLuL., The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility.mBio, 2016. 7(1): p. e01919-15.

 

专利:

  1. 陆玲,岳尚,魏华,王亭立,2021,一种sgRNA、重组质粒、敲除pyrG基因的细胞株的构建方法及其应用,授权专利号ZL201811256669.1,中国
  2. 陆玲,王亭立,2020,一种能在杏鲍菇中高效驱动外源基因表达的启动子, 公开号CN 111575291 A,申请号 202010482511.7,申请日 2020.05.29
  3. 魏华,陆玲,2019,杏鲍菇多糖在小鼠模型中降血脂和调节肠道菌群的功能,公开号CN110227082 A,申请日2019.6.24

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