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李斌

李斌 博士  动物学方向教授、博导

实验室:昆虫生理与功能基因组学   生科院大楼西-203

Emial  libinlb@hotmail.com libin@njnu.edu.cn

联系地址:南京市栖霞区文苑路1   南京师范大学生命科学学院

    编:210023

 

李斌,男,汉族,19717月生,四川武胜人,博士,教授,博士生导师。2004年获重庆市高校优秀中青年骨干教师计划资助,20093月获南京师范大学优秀高层次引进人才计划资助。多种昆虫基因组计划成员,先后加入中国昆虫学,中国蚕学会,中国遗传学会,中国生化与分子生物学会、美国昆虫学会,日本蛋白质科学学会,日本蚕丝昆虫学会等学术团体。作为负责人完成国家自然科学基金2项、国家教育部课题1项,省市项目4项。参与国家科技部973863、国家自然科学基金重点与面上、国家教育部、以及日本文部省与美国国家NIHUSDA项目等10余项。目前主持国家自然科学基金2项。

主要从事昆虫基因组与功能基因组学,蛋白质组学,分子、发育与神经生理学等研究。目前研究重点:1)利用基因组学,转录组学,蛋白组学及生物信息学对未知功能基因(或基因家族)进行鉴定与分析;2)对神经肽及其受体基因进行大规模解析,对孤儿受体进行鉴定,探讨神经肽基因及其受体基因的信号传导及其协同进化关系,并利用RNAi等手段探讨昆虫羽化,蜕皮,能量代谢,促心动,肌动,泌尿等发育、代谢调控的分子机制;3)昆虫抗药性及抗胁迫机理及其分子调节机制研究,利用基因组学与生物信息学手段等对昆虫抗药性及抗胁迫机理及其环境适应机制进行解析,探索其信号传导途径,进而阐明其进化适应机制及其在免疫与昆虫防治研究中的重要作用。

在国际著名学术期刊Genome Research(第1作者)、 ScienceNatureDNAResearchFrontiers in NeuroendocrinologyPest Management Science Insect Molecular BiologyGenomics Journal of Insect Physiology等国内外知名专业核心期刊上发表研究论文70余篇,另外在国际会议发表论文或摘要等 20余篇。

简历:

2009.3~至今,教授,南京师范大学优秀高层次引进人才

2005.11~2009.9Research Associate, Kansas State University(美国)

2004.10~2005.10,高级访问研究员,九州大学(日本)

2001.7~2005.10,副研究员与讲师, 西南农大

1998.9~2001.6,博士,遗传与分子生物学,西南农大与日本九州大学联合培养

1996.9~1998.9,硕士,生物化学与分子生物学,西南农大

1989.9~1993.7,本科,蚕学,西南农大

 

在研国家自然科学基金委项目:

1.无脊椎动物新型受体 Parathyroid hormone receptor like(PTHRL) 的鉴定及其对赤拟谷盗表皮发育的调控

2.赤拟谷盗蛛毒素受体Latrophilin的鉴定及其生理功能与进化适应性分析

 

2014-2020年内发表论文(* 为通讯作者)

  1. Jia Xie#, Ming Sang#, Xiaowen SongSisi ZhangDonghun KimJan A Veenstra*, Yoonseong Park*, Bin Li*. A new neuropeptide insect parathyroid hormone iPTH in the red flour beetle Triboliumcastaneum.PLoS Genetics, 2020,16(5): e1008772.(SCI, 2019 IF=5.175)
  2. Jia Xie, Guifang Peng, Xingxing Hu, Shasha Gu, Jingxiu Bi, Luting Wei, Jing Tang, XiaowenSong, Fan Feng, Bin Li*.Functional analysis of a novel orthologous small heat shock protein (shsp) hsp21.8a and seven species-specficshsps in Triboliumcastaneum. Genomics.2020, S0888-7543(20)30381-5. (SCI, 2019 IF=6.205)
  3. Xiaowen Song #, Qisheng Zhong #, Guifang PengYanhao JiYuemei ZhangJing TangJia XieJingxiu BiFan FengBin Li*. Functional characterization of a special dicistronic transcription unit encoding histone methyltransferase su(var)3-9 and translation regulator eIF2γ in Triboliumcastaneum. Biochemical Journal, 2020,477(16):3059-3074.(SCI, 2019 IF=4.097)
  4. Jingxiu Bi #, Mingxiao Ning # , Jia LiPing ZhangLumen WangShi XuYi ZhongZiyi WangQisheng SongBin Li*. A C‐type lectin with dual‐CRD from Triboliumcastaneum is induced in response to bacterial challenge.Pest Management Science,2020, 76(12):3965-3974.(SCI, 2019 IF=3.75)
  5. Jia LiJingxiu BiPing ZhangZiyi WangYi ZhongShi XuLumeng WangBin Li*. Functions of a C-type lectin with a single carbohydrate-recognition domain in the innate immunity and movement of the red flour beetle, Triboliumcastaneum.Insect Molecular Biology,2021, 30(1):90-101.(SCI, 2019 IF=2.533)
  6. Yuan-Chen ZhangShan-Shan GaoShuang XueKun-Peng ZhangJing-Shun WangBin Li*. Odorant-Binding Proteins Contribute to the Defense of the Red Flour Beetle, Triboliumcastaneum, Against Essential Oil of Artemisia vulgaris. Frontiers in Physiology. 2020 Aug;31;11:819. (SCI, 2019 IF=3.367)
  7. Shanshan Gao, Kunpeng Zhang, Luting Wei, Guanyun Wei, WenfengXiong, Yaoyao Lu, Yonglei Zhang, Aoxiang Gao, Bin Li*. Insecticidal Activity of Artemisia vulgaris Essential Oil and Transcriptome Analysis of Triboliumcastaneum in Response to Oil Exposure. Frontiersin Genetics. 2020, 25;11:589.(SCI, 2019 IF=3.26)
  8. Xiaowen Song, Lianghong Pei, Yuemei Zhang, Qisheng Zhong, Yanhao Ji, Jing Tang, Fan Feng, Bin Li*. Functional diversification of three delta-class glutathione S-transferases involved in development and detoxification inTriboliumcastaneum.Insect Molecular Biology.2020, 29(3):320-336. (SCI, 2019 IF= 2.437)
  9. Xiaowen Song, Yuemei Zhang, Qisheng Zhong, Keming Zhan, Jingxiu Bi, Jing Tang, Jia Xie, Bin Li*. Identification and functional characterization of methyl-CpG binding domain protein from Triboliumcastaneum. Genomics. 2019, 112(3):2223-2232. (SCI, 2019 IF= 3.16)
  10. WenfengXiong#, Shanshan Gao#, Jinjuan Mao, Luting Wei, Jia Xie, Juanjuan Liu, Jingxiu Bi, Xiaowen Song and Bin Li*. CYP4BN6 and CYP6BQ11 mediate insecticide susceptibility and their expression is regulated by Latrophilin in Triboliumcastaneum. Pest Management Science. 2019,75 (10):2744-2755. (SCI, 2019 IF= 3.75)
  11. WenfengXiong, Shanshan Gao, Yaoyao Lu, Luting Wei, Jinjuan Mao, Jia Xie, Quanquan Cao, Juanjuan Liu, Jingxiu Bi, Xiaowen Song, Bin Li*. Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Triboliumcastaneum. Pesticide Biochemistry and Physiology.2019, 159:107–117. (SCI, 2019 IF= 2.751)
  12. Jingxiu Bi, Fan Feng, Jia Li, Jinjuan Mao, Mingxiao Ning, Xiaowen Song, Jia Xie, Jing Tang, Bin Li*. A C-type lectin with a single-CRD involved in the innate immune response of Triboliumcastaneum. 2019, Insect Molecular Biology. 201928 (5): 649-661. (SCI, 2019 IF= 2.437)
  13. Wei Wu, MengfanZhai, Chengjun Li, Xiaojuan Yu, Xiaowen Song, Shanshan Gao, Bin Li*. Multiple functions of miR-8-3p in the development and metamorphosis of the red flour beetle,Triboliumcastaneum. Insect Molecular Biology. 2019, 28(2):208-221.(SCI, 2019 IF= 2.533)
  14. Luting wei#, Shanshan Gao#, WenfengXiong, Juanjuan Liu, Jinjuan Mao, Yaoyao Lu, Xiaowen Song, Bin Li*. Latrophilin mediates insecticides susceptibility and fecundity through two carboxylesterases, esterase4 and esterase6, in Triboliumcastaneum. Bulletin of Entomological Research. 2019109 (4): 534-543.(SCI, 2019 IF= 1.814)
  15. Shanshan Gao, WenfengXiong, Luting Wei, Juanjuan Liu, Xing Liu, Jia Xie, Xiaowen Song, Jingxiu Bi, Bin Li*. Transcriptome profiling analysis reveals the role oflatrophilin in controlling development, reproduction and insecticide susceptibility in Triboliumcastaneum. Genetica. 2018, 146(3):287-302. (SCI, 2019 IF= 1.186)
  16. Chengjun Li, Juanjuan Liu, Peng Lü, Shangshang Ma, Keming Zhu, Lu Gao, Bin Li*, Keping Chen*. Identification, expression and function of myosin heavy chain family genes in Triboliumcastaneum. Genomics. 2018, S0888-7543(18)30238-6.(SCI, 2019 IF= 6.205)
  17. Chengjun Li, Yaoyao Lu, Shangshang Ma, Peng Lü, Bin Li*, Keping Chen*. Crinkled employs wingless pathway for wing development in Triboliumcastaneum. Archives of insect biochemistry and physiology. 2018, 99(2):e21496.(SCI, 2019 IF= 1.536)
  18. ChengJun Li, XiaoPei Yun, XiaoJuan Yu, Bin Li*. Functional analysis of the circadian clock gene timeless in Triboliumcastaneum. Insect Science. 2018, 25, 418–428. (SCI, 2019 IF= 2.791)
  19. Jia Xie#, WenfengXiong#, Xingxing Hu, Shasha Gu, Sisi Zhang, Shanshan Gao, Xiaowen Song, Jingxiu Bi, Bin Li*. Characterization and functional analysis of hsp21.8b: An orthologous small heat shock protein gene in Triboliumcastaneum. Journal of applied entomology. 2018, 142(7): 654-666. (SCI, 2019 IF= 2.211)
  20. WenfengXiong#, Jia Xie#, Luting Wei, Sisi Zhang, Xiaowen Song, Shanshan Gao, Bin Li*. Transcriptome analysis of hsp18.3 functions and regulatory systems using RNA-sequencing in the red our beetle, Triboliumcastaneum. Journal of Integrative Agriculture. 2018, 17(5): 1040–1056. (SCI, 2019 IF= 1.984)
  21. Xiaowen Song#, Fei Huang#, Juanjuan Liu, Chengjun Li, Shanshan Gao, Wei Wu, MengfanZhai, Xiaojuan Yu, WenfengXiong, Jia Xie and Bin Li*.Genome-wide DNA methylomes from discrete developmental stages reveal the predominance of non-CpG methylation inTriboliumcastaneum.DNA Research.2017, 24(5): 445-457. (SCI, 2019 IF= 4.009)
  22. Jia Xie, XingXing Hu, MengFanZhai, XiaoJuan Yu, XiaoWen Song, ShanShan Gao, Wei Wu, Bin Li*. Characterization and functional analysis of hsp18.3 gene in the red flour beetle, Triboliumcastaneum. Insect Science. 2017, 26(2):263-273. (SCI, 2019 IF= 2.791)
  23. WenfengXiong, MengfanZhai, Xiaojuan Yu, Luting Wei, Jinjuan Mao, Juanjuan Liu, Jia Xie, Bin Li*. Comparative rna-sequencing analysis of ER-based hsp90 functions and signal pathways in Triboliumcastaneum. Cell Stress & Chaperones. 2017, 23(1):29-43. (SCI, 2019 IF= 2.892)
  24. Wei Wu, WenfengXiong, Chengjun Li, MengfanZhai, Yao Li, Fei Ma, Bin Li*, MicroRNA-dependent regulation of metamorphosis and identification of microRNAs in the red flour beetle, Triboliumcastaneum. Genomics. 2017, 109(5-6):362-373. (SCI, 2019 IF= 6.205)
  25. Chengjun Li, Bin Li*, Shangshang Ma, Peng Lv, Keping Chen*, Dusky works upstream of Four-jointed and Forked in wing morphogenesis in Triboliumcastaneum. Insect Molecular Biology. 2017, 26(6):677-686. (SCI, 2019 IF= 2.533)
  26. Shanshan Gao, Xing Liu, Juanjuan Liu, WenfengXiong, Xiaowen Song, Wei Wu, Luting Wei, Bin Li*. Identification and evolution of latrophilin receptor gene involved in Triboliumcastaneumdevolopment and female fecundity. Genesis. 2017, 55(12). doi: 10.1002/dvg.23081. (SCI, 2019 IF= 1.76)
  27. Chengjun Li, Xiaopei Yun,Bin Li*. Dusky-like is required for epidermal pigmentation and metamorphosis in Triboliumcastaneum. Scientific Reports. 2016, 6:20102. (SCI, 2019 IF= 3.998)
  28. Xuhong Chen, WenfengXiong, Chengjun Li, ShanshanGao, Xiaowen Song, Wei Wu,Bin Li*. Comparative RNA-sequencing profiling reveals novel Delta-class glutathione S-transferases relative genes expression patterns in Triboliumcastaneum. Gene. 2016, 593(1):13-20.(SCI, 2019 IF= 2.984)
  29. Ming Sang, Chengjun Li, Wei Wu, Bin Li*. Identification and evolution of two insulin receptor genes involved in Triboliumcastaneum development and reproduction. Gene. 2016, 585(2):196–204. (SCI, 2019 IF= 2.984)
  30. Ming Sang, Jiaxin Zhang, Bin Li*, Yuqing Chen*. TRAIL-CM4 fusion protein shows in vitro antibacterial activity and a stronger antitumor activity than solo TRAIL protein, Protein expression and purification. 2016, 122, 82-9. (SCI, 2019 IF= 1.513)
  31. Chengjun Li, Xiaopei Yun, Xiaojuan Yu, Bin Li*. Functional analysis of the circadian clock gene timeless in Triboliumcastaneum. Insect science. 2016, 25(3):418-428. (SCI, 2019 IF= 2.791)
  32. Yanyun Wang, Chengjun Li, Ming Sang, Bin Li*. Tcmof regulates larval/pupal development and female fecundity in red flour beetle, Triboliumcastaneum. Archives of Insect Biochemistry and Physiology. 2015, 88(2):111-22. (SCI, 2019 IF= 1.536)
  33. Chengjun Li, Yi Zhang, Xiaopei Yun, Yanyun Wang, Ming Sang, Xing Liu, Xingxing Hu and Bin Li*. Methuselah-like genes affect development, stress resistance, lifespan and reproduction in Triboliumcastaneum. Insect Molecular Biology. 2014, 23(5): 587-597. (SCI, 2019 IF= 2.533)
  34. Chengjun Li, Wei Wu, Ming Sang, Xing Liu, Xingxing Hu, Xiaopei Yun and Bin Li*. Comparative RNA-sequencing analysis of mthl1 functions and signal transductions in Triboliumcastaneum. Gene. 2014, 547: 310-318 (SCI, 2017 IF= 2.415) (SCI, 2019 IF= 2.984)
  35. Yi Zhang, Shasha Gu, Chengjun Li, Wei Wu, Xiaopei Yun, Xingxing Hu, Bin Li*. Identification and characterization of novel ER-based hsp90 gene in the red flour beetle, Triboliumcastaneum. Cell Stress and Chaperones. 2014, 19(5): 623-633. (SCI, 2019 IF= 2.892)
  36. Chengjun Li, Xiaowen Song, Xuhong Chen, Xing Liu, Ming Sang, Wei Wu, Xiaopei Yun, Xingxing Hu and Bin Li*. Identification and comparative analysis of G protein-coupled receptors in Pediculus humanushumanus. Genomics. 2014, 104: 58-67 (SCI, 2019 IF= 6.205)
  37. Yaping Liu, Chengjun Li, Jingkun Gao, Wenlong Wang, Li Huang, Xuezhu Guo, Bin Li, Jianjun Wang*. Comparative characterization of two intracellular Ca2+-release channels from the red flour beetle, Triboliumcastaneum. Scientific reports. 2014, 4: 6702. (SCI, 2019 IF= 3.998)

 

部分2014年以前的代表性论著* 为通讯作者

1. Bin Li, Reinhard Predel, Susanne Neupert, Frank Hauser, Yoshiaki Tanaka, Giuseppe Cazzamali, Michael Williamson, YasuyukiArakane, Peter Verleyen, Liliane Schoofs, Joachim Schachtner, Cornelis J.P. Grimmelikhuijzen, Yoonseong Park*. Genomics, transcriptomics, and peptidomics of peptide and protein hormones in the red flour beetle Triboliumcastaneum, Genome Research, 2008, 18: 113-122.(SCI, 2019 IF= 11.093)

2. Tribolium Genome Sequencing Consortium (Richards S., et al., Bin Li et al. One of 100+ Authors), The genome of the model beetle and pestTriboliumcastaneum. Nature. 2008, 452 (7190): 949-955. (SCI, 2019 IF= 42.779)

3. Biology analysis group, Qingyou Xia, Zeyang Zhou, Cheng Lu, Daojun Cheng, Fangyin Dai, Bin Li et al. (One of 100+ Authors), A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori). Science. 2004, 306(5703): 1937-1940. (SCI, 2019 IF=41.846)