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兰蕾

兰蕾

副教授,硕士生导师

联系方式:lanlei@njnu.edu.cn;lanlei1978@gmail.com

研究方向:

G蛋白偶联型受体在外周神经系统炎症及炎性痛中的作用机制

肠道细菌性炎症中致病菌-宿主相互作用的分子机制

主持的科研项目:
1、 国家自然科学基金-青年基金,2016-2018
2、 江苏省科技厅自然科学基金面上项目,2016-2019
3、 南京师范大学“青蓝工程”优秀中青年骨干教师,2016
4、 江苏省科技厅自然科学基金-青年基金,2012-2015

近期发表的论文:

  1. Shen, L., Qi, Z., Zhu, Y., Song, X., Xuan, C., Ben, P., Lan, L. *, Luo, L.*, and Yin, Z.* (2016). Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy. Cell Signal 28, 1086-1098.
  2. Messina, A., Lan, L., Incitti, T., Bozza, A., Andreazzoli, M., Vignali, R., Cremisi, F., Bozzi, Y., and Casarosa, S. (2015). Noggin-Mediated Retinal Induction Reveals a Novel Interplay Between Bone Morphogenetic Protein Inhibition, Transforming Growth Factor beta, and Sonic Hedgehog Signaling. Stem Cells 33, 2496-2508.
  3. Qi, Z., Shen, L., Zhou, H., Jiang, Y.,Lan, L.*, Luo, L.*, and Yin, Z.* (2014). Phosphorylation of heat shock protein 27 antagonizes TNF-alpha induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cell Signal 26, 1616-1625.
  4. Qi, S., Xin, Y., Qi, Z., Xu, Y., Diao, Y., Lan, L.*, Luo, L.*, and Yin, Z.* (2014). HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with beta-arrestin2. Cellular Signalling 26, 594-602.
  5. Ruan, J., Qi, Z., Shen, L., Jiang, Y., Xu, Y., Lan, L.*, Luo, L.*, and Yin, Z.* (2015). Crosstalk between JNK and NF-kappaB signaling pathways via HSP27 phosphorylation in HepG2 cells. Biochemical and biophysical research communications 456, 122-128.
  6. Pan, X., Cao, X., Li, N., Xu, Y., Wu, Q., Bai, J., Yin, Z., Luo, L., and Lan, L.* (2014). Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production. Inflamm Res 63, 597-608.
  7. Diao, Y., Xin, Y., Zhou, Y., Li, N., Pan, X., Qi, S., Qi, Z., Xu, Y., Luo, L., Wan, H.*,Lan, L.*, and Yin, Z.* (2014). Extracellular polysaccharide from Bacillus sp. strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-kappaB and MAPKs activation and ROS production. International Immunopharmacology 18, 12-19.
  8. Xin, Y., Yin, F., Qi, S., Shen, L., Xu, Y., Luo, L.*, Lan, L.*, and Yin, Z.* (2013). Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-kappaB activation and HSP70 up-regulation. Toxicology Letter 221, 73-82.
  9. Qi, Z., Yin, F., Lu, L., Shen, L., Qi, S.,Lan, L.*, Luo, L.*, and Yin, Z.* (2013). Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production. Inflamm Res 62, 845-855.
  10. Cao X., Yue L., Song J., Wu Q., Li N., Luo L.*, Lan L.*, and Yin Z.* (2012). Inducible HSP70 antagonizes IL-1beta cytocidal effects through inhibiting NF-kB activation via destabilizing TAK1 inHeLa cells. PLoS One 7, e50059.
  11. Lan, L., Vitobello, A., Bertacchi, M., Cremisi, F., Vignali, R., Andreazzoli, M., Demontis, G.C., Barsacchi, G., and Casarosa, S. (2009). Noggin elicits retinal fate in Xenopus animal cap embryonic stem cells. Stem Cells 27, 2146-2152.