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胡志刚

胡志刚,男

南京师范大学生命科学学院副教授,硕士生导师。

2009年毕业于韩国东亚大学自然资源与生命科学学院,获得理学博士学位。

2010年1月至2013年11月,在世界著名学府斯坦福大学医学院从事科研工作。

 

研究方向主要为:脂代谢,胆固醇代谢,类固醇激素分泌及DNA损伤修复等。

 

在研项目:

1. 高密度脂蛋白受体(SR-BI)的泛素化修饰及功能研究,2015.01-2017.12,国家自然科学基金青年项目

2.高密度脂蛋白受体(SR-BI)蛋白质翻译后修饰及功能研究,2014.07-2017.06,江苏省自然科学基金青年项目

3.高密度脂蛋白磷酸化修饰及功能研究,2014.08-2016.12,江苏省高校自然科学研究面上项目

4.miR-24 对高密度脂蛋白受体(SR-BI)的表达调控及机制研究,教育部留学回国人员科研项目启动基金

 

学术兼职:

美国生理学会会员,江苏省生理学会副秘书长,江苏省生物化学与分子生物学青年委员会委员

 

近年论文发表情况:

1.Hu Z, Shen WJ, et al., Regulation of adrenal and ovarian steroidogenesis by miR-132. Journal of Molecular Endocrinology. 2017. (Revised).

2. He L, Luo L, Zhu H, Yang H, Zhang Y, Wu H, Sun H, Jiang F, Kathera CS, Liu L, Zhuang Z, Chen H, Pan F, Hu Z, Zhang J, Guo Z.. FEN1 promotes tumor progression and confers cisplatin resistance in non‐small cell lung cancer[J]. Molecular Oncology, 2017.

3. Li J, Zhou Q, Ma Z, Wang M, Shen WJ, Azhar S, Guo Z, Hu Z(通讯作者). Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis[J]. Reproductive Biology and Endocrinology, 2017, 15(1): 19.

4. Pan F, Zhao J, Zhou T, Kuang Z, Dai H, Wu H, Sun H, Zhou X, Wu X, Hu Z, He L, Shen B, Guo Z. Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice. Sci Rep. 2016, 6:28614.

5. Sun H, He L, Wu H, Pan F, Wu X, Zhao J, Hu Z, Sekhar C, Li H, Zheng L, Chen H, Shen BH, Guo Z. The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation[J]. Oncogene, 2016.

6. Hu Z(一作并通讯), Li J, Kuang Z, et al. Cell-Specific Polymorphism and Hormonal Regulation of DNA Methylation in Scavenger Receptor Class B, Type I[J]. DNA and cell biology, 2016, 35(6): 280-289.

7. Zhou X, Zhuang Z, Wang W, He L, Wu H, Cao Y, Pan F, Zhao J, Hu Z, Sekhar C, Guo Z. OGG1 is essential in oxidative stress induced DNA demethylation. Cell Signal. 2016, 28(9):1163-1171.

8. Shen W J, Hu Z, Hu J, et al. Post-transcriptional and Post-translational Regulation of Steroidogenesis[M]//Post-transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, 2016: 253-275.

9. Zhou T, Pan F, Cao Y, Han Y, Zhao J, Sun H, Zhou X, Wu X, He L, Hu Z, Chen H, Shen B, Guo Z.. R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation. Oncotarget, 2016, 7(6): 6902.

10. Hu Z, Hu J, Shen W J, et al. A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity. Biochemistry, 2015, 54(46):6917-30.

11. Cao Y, .. Hu Z.., Guo Z. Selection and characterization of human PCSK9 antibody from phage displayed antibody library[J]. Biochemical and biophysical research communications, 2015, 463(4): 712-718.

12. Shen W J, Hu J, Hu Z, et al. Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions[J]. Metabolism, 2014, 63(7): 875-886.

13. Hu Z, Shen W J, Cortez Y, et al. Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland[J]. PloS one, 2013, 8(10): e78040-e78040.

14. Hu, Z., Hu, J., Zhang, Z., Shen, W. J., Yun, C. C., Berlot, C. H., ... & Azhar, S. (2013). Regulation of Expression and Function of Scavenger Receptor Class B, Type I (SR-BI) by Na+/H+ Exchanger Regulatory Factors (NHERFs). Journal of Biological Chemistry, 288(16), 11416-11435.

15. Hu, Z, et al. MicroRNAs 125a and 455 Repress Lipoprotein-Supported Steroidogenesis by Targeting Scavenger Receptor Class B Type I in Steroidogenic Cells. Molecular and Cellular Biology, 2012, 32(24): 5035-5045.

16. Hu Z., Lee K.S., et al. Molecular characterization of 1-Cys and 2-Cys peroxiredoxins from the bumblebee Bombus ignitus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010, 155(3): 272-280

17. Hu Z. et al. Molecular characterization of a phospholipid hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010, 155(1): 54-61

18. Xin Y., Choo Y.M., Hu Z., et al. Molecular cloning and characterization of a venom phospholipase A(2) from the bumblebee Bombus ignitus. Comp Biochem Physiol B Biochem Mol Biol. 2009, 154(2): 195-202.

19. Hu Z., & Sohn, H. D. (2009). Molecular Cloning and Characterization of a Lipocalin in the Bumblebee Bombus Ignitus. International Journal of Industrial Entomology, 19(2), 229-235.

20. Hu Z., et al. Molecular Cloning and Characterization of a Muscle-Specific Lipase from the Bumblebee Bombus ignitus.International Journal of Industrial Entomology, 2008, 17(1): 143-151.

21. Zhao Y., Yao Q., Tang Xu., Wang Q., Hu Z., et al. Cloning and homologic analysis of Tpn I gene in silkworm bombyx mori, African Journal of Biotechnology, 2007, 6(6): 672-676.

22. Hu Z., et al. Cloning and Characterization of Bombyx mori PP-BP a Gene Induced by Viral Infection, Acta Genetica Sinica, 2006, 33(11): 975-983.

23. Hu Z., Chen K., Gao L., Yao Q. RNA Interference to Prevent Bombyx mori Nuclear Polyhedrosis Virus Infection in Vivo, IJIE, 2006, 12(1):15-19.

24. Yao Q., Gao L., Chen K., Hu Z. Detection of proliferation of Bombyx mori nucleopolyhedrovirus in its host by fluorescence quantitative PCR. Acta entomological sinica. 2005,48(6):871-875. In Chinese.

25. Hu Z. et al. Identification and characterization of Bombyx mori eIF5A gene through bioinformatics approaches, In Silico Biology, 2005, 5: 0051.

26. Yao Q., Hu Z., Chen K. Cloning and Characterization of Ribosome-associated Membrane Protein 4 (RAMP4) gene in silkworm Bombyx mori, International Journal of Industrial Entomology, 2005, 10(2):125-129.

 

Email: huzg_2000@126.com