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韩管助

职称：教授

学历：博士

邮箱：guanzhu@@njnu.edu.cn(发邮件时请去掉一个@)

电话：025-85891836

 

工作经历

 

2015至今：南京师范大学，生命科学学院，教授

 

教育经历

 

2010-2014：美国University of Arizona，生态与进化生物学专业，博士

2005-2009：山东师范大学，生物技术专业，学士

 

研究方向

 

由病毒引发的流行病正严重地威胁着全球公共卫生安全以及社会经济发展。理解病毒进化对于病毒流行病的监测、防控以及预测具有十分重要的意义。我们实验室在进化生物学框架下整合了野外采样、分子生物学、进化分析和理论算法开发等方法来研究病毒的多样性和进化以及病原与宿主间互作的进化。我们实验室主要研究方向包括：

  • 病毒进化和古病毒学；
  • 新发流行病起源和进化；
  • 宿主与病原间进化军备竞赛；
  • 分子进化和进化基因组学。

 

论文著作（*通讯作者）

 

  1. Xu X, Zhao H, Gong Z, Han GZ*. (2018). Endogenous retroviruses of non-avian/mammalian vertebrates illuminate diversity and deep history of retroviruses. PLOS Pathogensdoi: 10.1371/journal.ppat.1007072
  2. Gao Y, Wang W, Zhang T, Gong Z, Zhao H, Han GZ*. (2018). Out of water: the origin and early diversification of plant R-genes. Plant Physiology177:82-89.

（同期Plant Physiology的On the Inside对该论文进行了推荐）

  1. Gong Z, Han GZ*. (2018). Euphyllophyte paleoviruses illuminate hidden diversity and macroevolutionary mode of Caulimoviridae. Journal of Virology92:e02043-17.
  2. Wang W, Han GZ*. (2018). The expanding diversity of RNA viruses in vertebrates. Trends in Microbiology26:465-466.
  3. Han GZ*. (2017). Evolution of jasmonate biosynthesis and signaling mechanisms. Journal of Experimental Botany 68:1323-1331.
  4. Gong Z, Xu X, Han GZ*. (2017). The diversification of Zika virus: Are there two distinct lineages? Genome Biology and Evolution9:2940-2945.
  5. Ren Q, Wang C, Jin M, Lan J, Ye T, Hui K, Tan J, Wang Z, Wyckoff G*, Wang W, Han GZ*. (2017). Co-option of bacteriophage lysozyme genes by bivalve genomes. Open Biology7:160285.
  6. Gong Z, Xu X, Han GZ*. (2017). ‘Patient 0’ and the origin of HIV/AIDS in America. Trends in Microbiology 25:3-4.
  7. Han GZ*. (2017). A single substitution changes Zika virus infectivity in mosquitoes. Trends in Microbiology 25:603-605.
  8. Gao Y, Zhao H, Jin Y, Xu X, Han GZ*. (2017). Extent and evolution of gene duplication in DNA viruses. Virus Research240:161-165.
  9. Gong Z, Gao Y, Han GZ*. (2016). Zika virus: two or three lineages. Trends in Microbiology24:521-522.
  10. Du L, Han GZ*. (2016). Deciphering MERS-CoV evolution in dromedary camels. Trends in Microbiology 24:87-89.
  11. Song J, Zhai P, Zhang Y, Zhang C, Sang H, Han GZ, Keller NP, Lu L. (2016). The Aspergillus fumigatus damage resistance protein family coordinately regulates ergosterol biosynthesis and azole susceptibility. mBio7:e01919-15.
  12. Wang C, Li S*, Han GZ*. (2016). Commentary: Plant auxin biosynthesis did not originate in charophytes. Frontiers in Plant Science 7:158.
  13. Chen R, Han GZ. (2016). Dengue in China: comprehensive phylogenetic evaluation reveals evidence of endemicity and complex genetic diversity. American Journal of Tropical Medicine and Hygiene94:198-202.
  14. Han GZ*, Worobey M*. (2015). A primitive endogenous lentivirus in a colugo: insights into the early evolution of lentiviruses. Molecular Biology and Evolution 32:211-215.
  15. Wang C, Liu Y, Li S*, Han GZ*.(2015). Insights into the origin and evolution of plant hormone signaling machinery. Plant Physiology 167:872-886.

（同期Plant Physiology的On the Inside对该论文进行了推荐，Current Opinion in Microbiology和Current Opinionin Plant Biology推荐为of special interest和of outstanding interest文章，入选ESI植物和动物科学高被引论文）

  1. Han GZ*. (2015). Extensive retroviral diversity in shark. Retrovirology 12:34.
  2. Worobey M*, Han GZ, Rambaut A*. (2014). A synchronized global sweep of the internal genes of modern avian influenza virus. Nature508:254-257.

（Nature Reviews Microbiology作为研究亮点进行了推荐，Nature News对该论文进行了报道，入选ESI微生物学高被引论文）

  1. Wang C, Liu Y, Li S*, Han GZ*. (2014). Origin of plant auxin biosynthesis in charophyte algae. Trends in Plant Science19:741-743.
  2. Worobey M*, Han GZ, Rambaut A. (2014). The genesis and pathogenesis of the 1918 influenza pandemic. Proceedings of the National Academy of Sciences of the United States of America111:8107-8112.

（帝国理工学院Steven Riley教授在同期PNAS撰写了Commentary对该论文进行了推荐，纽约时报、国家地理等媒体对该论文进行了报道）

  1. Han GZ*, Worobey M*. (2014). Endogenous viral sequences from the Cape golden mole (Chrysochlorisasiatica) reveal the presence of foamy viruses in all major placental mammal clades. PLOS ONE9:e97931.
  2. Worobey M, Han GZ. (2013). The origins and diversification of HIV. In, Sande's HIV/AIDS Medicine: Medical Management of AIDS 2013. Volberding PA, Greene WC, Lange J, Gallant JE, and Sewankambo N Eds. (Saunders Elsevier, Philadelphia).
  3. Han GZ*, Worobey M*. (2012). Endogenous lentiviral elements in the weasel family (Mustelidae). Molecular Biology and Evolution 29:2905-2908.
  4. Han GZ*, Worobey M*. (2012). An endogenous foamy-like viral element in the coelacanth genome. PLOS Pathogens8:e1002790.
  5. Han GZ*, Worobey M*. (2012). An endogenous foamy virus in the aye-aye (Daubentoniamadagascariensis). Journal of Virology 86:7696-7698.
  6. Han GZ*, Worobey M. (2011). Homologous recombination in negative sense RNA viruses. Viruses 3:1358-1373.
  7. Han GZ*, Boni MF, Li S*. (2010). No observed effect of homologous recombination on the evolution of influenza C virus. Virology Journal 7:227.
  8. He C, Xie Z, Han GZ, Dong J, Wang D, Liu J, Ma L, Tang X, Liu X, Pang Y, Li G.(2009). Homologous recombination as an evolutionary force in the avian influenza A virus. Molecular Biology and Evolution 26:177-187.
  9. Wang D, Fan W, Han GZ, He C. (2009). The selection pressure analysis of chicken anemia virus structural protein gene VP1. Virus Genes 38:259-262.
  10. Sun X, Wu K, Zhao Y, Kong F, Han GZ, Jiang H, Huang X, Li R, Wang H, Li S. (2009). QTL analysis for kernel shape and weight using recombinant inbred lines in wheat. Euphytica 165:615-624.
  11. Han GZ*, Liu X, Li S. (2008). Caution about Newcastle disease virus-based live attenuated vaccine. Journal of Virology 82:6782.
  12. Han GZ, He C, Ding N, Ma L. (2008). Identification of a natural multi-recombinant of Newcastle disease virus. Virology371:54-60.
  13. Han GZ*, Liu X, Li S*. (2008). Cross-species recombination in the haemagglutinin gene of canine distemper virus. Virus Research 136:198-201.
  14. Han GZ*, Liu X, Li S*. (2008). Homologous recombination is unlikely to play a major role in influenza B virus evolution. Virology Journal 5:65.
  15. He C, Han GZ, Wang D, Liu W, Li G, Liu X, Ding N. (2008). Homologous recombination evidence in human and swine influenza A viruses. Virology 380:12-20.
  16. Li L, Wang J, Guo Y, Jiang F, Xu Y, Wang Y, Pan H, Han GZ, Li R, Li S. (2008). Development of SSR makers from ESTs of gramineous species and their chromosome location on wheat. Progress in Natural Science 18:1485-1490.

 

荣誉与奖励

 

2016：南京师范大学百名青年领军人才

2013：美国亚利桑那大学Robert W. Hoshaw Memorial Scholarship

2013：美国亚利桑那大学Galileo Circle Scholarship

2010：山东省优秀学士学位论文

2009：第11届挑战杯全国大学生课外学术科技作品竞赛全国特等奖

2008：国家奖学金

2007：第10届挑战杯全国大学生课外学术科技作品竞赛全国一等奖

2007：山东师范大学校长奖学金

 

学术服务

 

Nature Communications、Molecular Biology and Evolution、Trends in Microbiology、PLOSGenetics、Journal of Virology、PlantPhysiology、MolecularPlant、EvolutionaryApplications、Plant Molecular Biology、Planta、Journal of Clinical Microbiology、Virulence、Vaccine、Viruses、Virology、VirusEvolution、VirologyJournal、Journal of Wildlife Diseases、SCIENCE CHINA Life Sciences、VirologicaSinica等杂志审稿人