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陈昌斌*

陈昌斌 (Changbin Chen) 博士,研究员
微生物、发育与健康研究中心研究员
病原真菌感染及宿主免疫研究组组长
中科院上海巴斯德研究所麒麟创新研究院
南京市江宁区麒麟智慧神州产业园七栋
邮编:200031
电话:021-54923055
邮箱: cbchen@ips.ac.cn
教育及工作经历
2013 年 7 月-至今 中国科学院上海巴斯德研究所,研究员,博士生导师,
“百人计划”获得者 (2014)
2011 年 7 月-2013 年 6 月 美国加州大学旧金山分校微生物和免疫学系,
助理研究员 (UCSF, Assistant Specialist)
2005 年 7 月-2011 年 6 月 美国加州大学旧金山分校, 博士后
从师生物化学家 Hiten D. Madhani 博士及真
菌病理学家 Suzanne M. Noble 博士
2004 年 9 月-2005 年 6 月 美国内布拉斯加州立大学林肯分校植物病理系,
研究助理 (The University of Nebraska-Lincoln, Research Assistant)
1998 年 8 月-2004 年 8 月 美国内布拉斯加州立大学林肯分校,博士
从师著名植物病理学家 Martin B. Dickman 博士
1995 年 9 月-1998 年 6 月 中国科学院上海植物生理生态研究所分子遗传学,硕士
从师沈善炯院士、俞冠翘研究员
1990 年 9 月-1995 年 6 月 上海复旦大学生命科学院植物学, 学士
研究方向 
基础研究方面:揭示人类致病真菌共生和感染的分子机制,毒力基因表达调控机制以及宿
主抗真菌的免疫应答机理,以期为控制和预防真菌感染提供理论依据,并在此基础上发现
抗真菌药物的新作用靶点。
临床转化方面:主要针对临床重要的传染性疾病防治,包括微生物耐药、器官移植过程的
共感染、真菌感染引起的妇科疾病、皮肤感染、脑膜炎和败血症等,运用宏基因组、蛋白
组、基因转录组及代谢组学技术,结合实验动物模型,研发病原诊断新技术及筛选新型抗
感染先导药物。
已发表学术论文 20 余篇,包括国际学术期刊 Cell, Nature Genetics, Cell Host & microbe, PLOS Pathogens, PNAS, Nature Immunology, Autophagy, Journal of Immunology, Molecular Microbiology, Eukaryotic cell 等。
主要研究成果
1 Silao FGS, Ryman K, Jiang T, Ward M, Hansmann N, Molenaar C, Liu NN, Chen C,  Ljungdahl PO. (2020) Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable  for escape from macrophages and virulence of Candida albicans. PLOS Pathogens, 16(9):  e1008328
2 Mei Y…Chen C*, Liu N*, Wang H* . (2020) FDA approved drug library screening identifies  Robenidine as a repositionable antifungal. Front Microbiol. 11:996. (co-corresponding  author)
3 Li Y, Li H, Sui M, Li M, Wang J, Meng Y, Sun T, Liang Q, Suo C, Gao X, Li C, Li Z, Du W,  Zhang B, Sai S, Zhang Z, Ye J, Wang H, Yue S, Li J, Zhong M, Chen C, Qi S, Lu L, Li D,  Ding C. (2019) Fungal acetylome comparative analysis identifies an essential role of  acetylation in human fungal pathogen virulence. Commun Biol. 2:154.
4 Mao Y and Chen C*. (2019) The Hap complex in yeasts: structure, assembly mode and gene  regulation. Front Microbiol. 10:1645. (corresponding author)
5 Tian, Y., ….. and Chen, C*. (2018) Sequence modification of the master regulator Pdr1  interferes with its transcriptional autoregulation and confers altered azole resistance in  Candida glabrata. FEMS Yeast Res. 18(4). (corresponding author)
6 Chen, C* and Huang C. (2018) Candida albicans Commensalism and Human Diseases. In  book: Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human  Diseases. E.d. Jun Sun and Dudeja PK. Physiology in Health and Disease. Springer. ISBN  978-1-4939-7533-4 (corresponding author)
7 Huang, X., …. and Chen, C*. (2017) Mitochondrial complex I bridges a connection between  regulation of carbon flexibility and gastrointestinal commensalism in the human pathogen  Candida albicans. PLOS Pathogens 13(6): e1006414. (corresponding author) 
8 Gao, N., and Chen, C*. (2016) Candida Infections: an update on host immune defenses and  anti-fungal drugs. IDTM. Review. (corresponding author)
9 Pande, K., Chen, C. and Noble, S. M. (2013) Passage through the mammalian gut triggers a  phenotypic switch required for Candida albicans commensalism. Nature Genetics.  45(9):1088-91
10 Deng Z., Ma S., Zhou H., Zang A., Fang Y., Li T., Shi H., Liu M., Du M., Taylor P., Zhu H.,  Chen J., Meng G., Li F., Chen C., Zhang Y., Jia X., Lin X., Zhang X., Pearlman E., Li X.,  Feng G., and Xiao H. (2015) Shp2 mediates C-type lectin receptor-induced Syk activation and  anti-fungal Th17 responses. Nature Immunology. 16(6):642-52.
11 Xie X., Li F., Wang Y., Lin Z., Cheng X., Liu J., Chen C., and Pan L. (2015) Molecular basis  of ubiquitin recognition by the autophagy receptor CALCOCO2. Autophagy. 11(10):1775-89.
12 Chen M., Xing Y., Lu A., Fang W., Sun B., Chen C., Liao W., and Meng G. (2015)  Internalized Cryptococcus neoformans activates the canonical Caspase-1 and the noncanonical  Caspase-8 inflammasomes. J. Immunol. 195(10):4962-72.
13 Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G. (2014) Acapsular
Cryptococcus neoformans activates the NLRP3 inflammasome. Microbes Infect. 16(10): 845-
54.
14 Chen, C. and Noble, S. M. (2012) Post-transcriptional regulation of the Sef1 transcription  factor controls the virulence of Candida albicans in its mammalian host. PLOS Pathogens,  8(11): e1002956.
15 Chen, C*., Pande, K*., French, S. D., Tuch, B. B. and Noble, S. M. (2011) A unique iron  homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and  pathogenesis. Cell Host & Microbe. 10(2): 118-35. (*equal contribution)
16 Dumesic, P., Natarajan, P., Chen, C., Drinnenberg, A., Schiller, B., Moresco, J., Thompson,  J., Yates, J., Bartel, D., and Madhani H. (2013) Stalled spliceosomes are a signal for RNAi-  mediated genome defense. Cell: 152(5):957-968.
17 Liu, O. W., Chun, C. D., Chow, E. D., Chen, C., Madhani, H. D. and Noble, S. M. (2008)  Systematic gene deletion and analysis of virulence in the human fungal pathogen  Cryptococcus neoformans. Cell 135(1): 174-188.
18 Chen, C. and Dickman, M. B. (2005) Proline suppresses apoptosis in the fungal pathogen  Colletotrichum trifolii. PNAS 102(9): 3459-3464
19 Georgette, C., Chen, C., Shih, S., et al., (2011) A site specific acetylation mark on the  essential RSC chromatin remodeling complexpromotes resistance to replication stress. PNAS  108(26):10620-10625
20 Chen, C. and Dickman, M. B. (2005) cAMP blocks MAPK activation and sclerotial  development via Rap-1 in a PKA-independent manner in Sclerotinia sclerotiorum. Molecular  Microbiology 55(1): 299-311.
21 Chen, C., and Dickman, M. B. (2004) Dominant active Rac and dominant negative Rac revert  the dominant active Ras phenotype in Colletotrichum trifolii by distinct signaling pathways.  Molecular Microbiolology 51: 1493-1507.
22 Chen, C., Ha, Y-S., Min, J-Y., Memmott, S. D., and Dickman, M. B.. (2006) Cdc42 is 
required for proper growth and development in the fungal pathogen Colletotrichum trifolii. Eukaryotic Cell 5(1): 155-166.
23 Scheffer, J., Chen, C., Heidrich, P., Dickman, M. B., and Tudzynski, P. (2005) A CDC42  homologue in Claviceps purpurea is involved in vegetative differentiation and is essential for  pathogenicity. Eukaryotic Cell 4(7): 1228-1238.
24 Chen, C., and Dickman, M. B. (2002) Colletotrichum trifolii TB3 kinase, a COT1 homolog, is  light inducible and becomes localized in the nucleus during hyphal elongation. Eukaryotic  Cell 1: 626-633.
25 Chen, C., Harel, A., Gorovoits, R., Yarden, O., and Dickman, M. B. (2004) MAPK regulation  of sclerotial development in Sclerotinia sclerotiorum is linked with pH and cAMP sensing.  Molecular Plant-Microbe Interactions 17: 404-413.
26 Kim, H.J., Chen, C., Kabbage, M. and Dickman, M.B. (2011) Identification and  Characterization of Sclerotinia sclerotiorum NADPH Oxidases. Applied and Environmental  Microbiology 77(21):7721-9.
27 Chen, C., Wanduragala, S., Becker, D. F., and Dickman, M. B. (2006) A tomato QM-like  protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating  intracellular proline levels. Applied and Environmental Microbiology 72(6): 4001-6.
28 王园园,陈昌斌 *(2018)分泌型蛋白介导白念珠菌与宿主相互作用分子机制的研究进
展。 菌物学报
29 姜彤,陈昌斌 *(2020)念珠菌适应宿主环境压力的共生机制研究进展。 菌物学报
(已接收)
30 陈昌斌,戴小密,俞冠翘,沈善炯(1999)组成型 nifA 对大豆根瘤菌(Rhizobium
fredii)HN01lux 结瘤固氮效率的促进作用。科学通报,第 5 期
31 阎力君,吕欣彧, 张多, 陈昌斌, 张爽, 高原, 雒江菡, 王福龄, 崔闻宇,张乘蚬
(2019)黄连解毒汤有效成分的提取及其对体内白色念珠菌的清除作用。中国畜牧兽
医,第11期
社会职务
中国菌物学会真菌基因组学专业委员会 副主任委员
中国菌物学会药用真菌学专业委员会 委员
中国药理学会化疗药理专委会 委员
中国微生物学会分析微生物专业委员会 委员
中国微生物学会真菌学专业委员会 委员 
上海市医学会分子诊断专科分会感染性疾病学组 专家成员
广东省广州市妇女儿童医疗中心 客座教授
Frontiers in Microbiology 编委
Frontiers in Pharmacology-Gastrointestinal and Hepatic Pharmacology Review Editor
中国真菌学杂志 编委
Infectious Disease & Translational Medicine Journal, Section Editor (Fungal field)
国家基金委优青、地区合作、面上及青年基金评审专家
国家卫健委“重大新药创制”科技重大专项 评审专家
国家卫健委 “传染病防治专项”科技重大专项 评审专家 (初审、二审及终审)
科技部“主动健康和老龄化科技应对”科技重大专项 会评专家
获得荣誉及奖励
2014 中国科学院“百人计划”获得者
2006 Herbert Boyer Postdoctoral Fellowship, Department of Biochemistry & Biophysics,  University of California, San Francisco
2006 UCSF Comprehensive Cancer Center/Stewart Trust Research Award
2002 Widaman Trust Distinguished Graduate Assistant Award, Institute of Agriculture and  Natural Resources, University of Nebraska-Lincoln
2004 Goss Memorial Scholarship, Department of Plant Pathology, University of Nebraska-  Lincoln
2003 Goss Memorial Scholarship, Department of Plant Pathology, University of Nebraska-  Lincoln
2001 Goss Memorial Scholarship, Department of Plant Pathology, University of Nebraska-  Lincoln
2000 Goss Memorial Scholarship, Department of Plant Pathology, University of Nebraska-  Lincoln