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EGF-functionalised Single-walled Carbon Nanotubes for Targeting Delivery of Etoposide

作者: 
Cheng Chen, Xiao-Xia Xie, Qian Zhou, Feng-Yi Zhang,Qiao-LingWang, Ya-Qing Liu, Yina Zou, Qing Tao, Xue-Mei Ji and Shu-Qin Yu
发表年度: 
2012
卷: 
23
期: 
4
页码: 
045104 (12pp)
摘要: 

To enhance the therapeutic potential of etoposide (ETO), we devised a targeted drug delivery system (TDDS) of epidermal growth factor–chitosan–carboxyl single-walled carbon nanotubes–ETO (EGF/CHI/SWNT–COOHs/ETO) using modified SWNTs (m-SWNTs) as the carrier, EGF-functionalized SWNTs (f-SWNTs) as the targeted moiety and ETO as the drug. After SWNT–COOHs were conjugated with CHI (CHI/SWNT–COOHs/ETO), they displayed high solubility and stable dispersion in aqueous solution. The drug loading capacity was approximately 25–27%. The m-SWNTs and f-SWNTs had only slight cytotoxicity. ETO was released from EGF/CHI/SWNT–COOHs/ETO at low pH and taken up by tumour cells via adenosine triphosphate (ATP)-dependent endocytosis. The cell death induced by EGF/CHI/SWNT–COOHs/ETO was as much as 2.7 times that due to ETO alone. In summary, these results demonstrated that our TDDS had a greater anticancer effect than free ETO in vitro.

刊物名称: 
NANOTECHNOLOGY